Click here to access PB0255 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0255 Q2I0M5 R-spondin-4 RSPO4 C20orf182, CRISTIN4 Homo_sapiens Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21727895, PubMed:21909076).

DomainsGene Ontology
PF15913 (Furin-like_2)
GO:0035878 (acts upstream of or within) nail development
GO:0005515 (enables) protein binding
GO:0008201 (enables) heparin binding
GO:0016055 (involved in) Wnt signaling pathway
GO:0030177 (involved in) positive regulation of Wnt signaling pathway
GO:0050896 (involved in) response to stimulus
GO:0005576 (located in) extracellular region

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)