Click here to access PB0254 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0254 Q9BXY4 R-spondin-3 RSPO3 CRISTIN1, PWTSR, THSD2 Homo_sapiens Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (PubMed:29769720).

DomainsGene Ontology
PF15913 (Furin-like_2)
PF19028 (TSP1_spondin)
GO:0005102 (enables) signaling receptor binding
GO:0005109 (enables) frizzled binding
GO:0008201 (enables) heparin binding
GO:0001525 (involved in) angiogenesis
GO:0001974 (involved in) blood vessel remodeling
GO:0002040 (involved in) sprouting angiogenesis
GO:0016055 (involved in) Wnt signaling pathway
GO:0030177 (involved in) positive regulation of Wnt signaling pathway
GO:0050896 (involved in) response to stimulus
GO:0060070 (involved in) canonical Wnt signaling pathway
GO:0060670 (involved in) branching involved in labyrinthine layer morphogenesis
GO:0090263 (involved in) positive regulation of canonical Wnt signaling pathway
GO:2000052 (involved in) positive regulation of non-canonical Wnt signaling pathway
GO:2000096 (involved in) positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:0005576 (located in) extracellular region

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)