Click here to access PB0253 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0253 Q6UXX9 R-spondin-2 RSPO2 CRISTIN2, HHRRD, TETAMS2 Homo_sapiens During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720).

DomainsGene Ontology
PF15913 (Furin-like_2)
GO:0005102 (enables) signaling receptor binding
GO:0005515 (enables) protein binding
GO:0008201 (enables) heparin binding
GO:0001649 (involved in) osteoblast differentiation
GO:0016055 (involved in) Wnt signaling pathway
GO:0030177 (involved in) positive regulation of Wnt signaling pathway
GO:0030282 (involved in) bone mineralization
GO:0035115 (involved in) embryonic forelimb morphogenesis
GO:0035116 (involved in) embryonic hindlimb morphogenesis
GO:0042489 (involved in) negative regulation of odontogenesis of dentin-containing tooth
GO:0050896 (involved in) response to stimulus
GO:0060070 (involved in) canonical Wnt signaling pathway
GO:0060173 (involved in) limb development
GO:0060437 (involved in) lung growth
GO:0060441 (involved in) epithelial tube branching involved in lung morphogenesis
GO:0060535 (involved in) trachea cartilage morphogenesis
GO:0071542 (involved in) dopaminergic neuron differentiation
GO:0090263 (involved in) positive regulation of canonical Wnt signaling pathway
GO:0005576 (located in) extracellular region
GO:0009986 (located in) cell surface

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)