Click here to access PB0252 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0252 Q2MKA7 R-spondin-1 RSPO1 CRISTIN3, RSPO Homo_sapiens Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805).

DomainsGene Ontology
PF00090 (TSP_1)
PF15913 (Furin-like_2)
GO:0001664 (enables) G protein-coupled receptor binding
GO:0005102 (enables) signaling receptor binding
GO:0005515 (enables) protein binding
GO:0008201 (enables) heparin binding
GO:0001934 (involved in) positive regulation of protein phosphorylation
GO:0002090 (involved in) regulation of receptor internalization
GO:0016055 (involved in) Wnt signaling pathway
GO:0030177 (involved in) positive regulation of Wnt signaling pathway
GO:0050896 (involved in) response to stimulus
GO:0090263 (involved in) positive regulation of canonical Wnt signaling pathway
GO:0005576 (located in) extracellular region
GO:0005634 (located in) nucleus

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)