Click here to access PB0250 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0250 Q99217 Amelogenin, X isoform AMELX AI1E, AIH1, ALGN, AMG, AMGL, AMGX Homo_sapiens Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.

DomainsGene Ontology
GO:0005515 (enables) protein binding
GO:0008083 (enables) growth factor activity
GO:0030345 (enables) structural constituent of tooth enamel
GO:0042802 (enables) identical protein binding
GO:0046848 (enables) hydroxyapatite binding
GO:0001649 (involved in) osteoblast differentiation
GO:0001837 (involved in) epithelial to mesenchymal transition
GO:0002062 (involved in) chondrocyte differentiation
GO:0007155 (involved in) cell adhesion
GO:0007165 (involved in) signal transduction
GO:0007584 (involved in) response to nutrient
GO:0009410 (involved in) response to xenobiotic stimulus
GO:0031214 (involved in) biomineral tissue development
GO:0032967 (involved in) positive regulation of collagen biosynthetic process
GO:0034505 (involved in) tooth mineralization
GO:0042127 (involved in) regulation of cell population proliferation
GO:0042475 (involved in) odontogenesis of dentin-containing tooth
GO:0051592 (involved in) response to calcium ion
GO:0070166 (involved in) enamel mineralization
GO:0070172 (involved in) positive regulation of tooth mineralization
GO:0097186 (involved in) amelogenesis
GO:0005576 (located in) extracellular region
GO:0005737 (located in) cytoplasm
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005794 (located in) Golgi apparatus
GO:0009986 (located in) cell surface
GO:0030139 (located in) endocytic vesicle
GO:0031012 (located in) extracellular matrix
GO:0062023 (located in) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)