Click here to access PB0248 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0248 P18206 Vinculin VCL CMD1W, CMH15, HEL114, MV, MVCL Homo_sapiens Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

DomainsGene Ontology
PF01044 (2_Vinculin)
GO:0002162 (enables) dystroglycan binding
GO:0003779 (enables) actin binding
GO:0005198 (enables) structural molecule activity
GO:0005515 (enables) protein binding
GO:0008013 (enables) beta-catenin binding
GO:0031625 (enables) ubiquitin protein ligase binding
GO:0045294 (enables) alpha-catenin binding
GO:0045296 (enables) cadherin binding
GO:0002009 (involved in) morphogenesis of an epithelium
GO:0007155 (involved in) cell adhesion
GO:0007160 (involved in) cell-matrix adhesion
GO:0030032 (involved in) lamellipodium assembly
GO:0030334 (involved in) regulation of cell migration
GO:0030336 (involved in) negative regulation of cell migration
GO:0034333 (involved in) adherens junction assembly
GO:0034394 (involved in) protein localization to cell surface
GO:0035633 (involved in) maintenance of blood-brain barrier
GO:0043297 (involved in) apical junction assembly
GO:0048675 (involved in) axon extension
GO:0051893 (involved in) regulation of focal adhesion assembly
GO:0070527 (involved in) platelet aggregation
GO:0090136 (involved in) epithelial cell-cell adhesion
GO:1903140 (involved in) regulation of establishment of endothelial barrier
GO:1904702 (involved in) regulation of protein localization to adherens junction
GO:0044291 (is active in) cell-cell contact zone
GO:0002102 (located in) podosome
GO:0005576 (located in) extracellular region
GO:0005737 (located in) cytoplasm
GO:0005829 (located in) cytosol
GO:0005856 (located in) cytoskeleton
GO:0005886 (located in) plasma membrane
GO:0005911 (located in) cell-cell junction
GO:0005912 (located in) adherens junction
GO:0005916 (located in) fascia adherens
GO:0005925 (located in) focal adhesion
GO:0015629 (located in) actin cytoskeleton
GO:0016020 (located in) membrane
GO:0030055 (located in) cell-substrate junction
GO:0034774 (located in) secretory granule lumen
GO:0035580 (located in) specific granule lumen
GO:0042383 (located in) sarcolemma
GO:0043034 (located in) costamere
GO:0070062 (located in) extracellular exosome
GO:0070161 (located in) anchoring junction
GO:1903561 (located in) extracellular vesicle
GO:1904813 (located in) ficolin-1-rich granule lumen
GO:0032991 (part of) protein-containing complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)