Click here to access PB0247 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0247 Q96AC1 Fermitin family homolog 2 FERMT2 KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2 Homo_sapiens Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.

DomainsGene Ontology
PF00169 (PH)
PF00373 (FERM_M)
PF18124 (Kindlin_2_N)
GO:1902414 (acts upstream of or within) protein localization to cell junction
GO:0003779 (enables) actin binding
GO:0005178 (enables) integrin binding
GO:0005515 (enables) protein binding
GO:0005547 (enables) phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008289 (enables) lipid binding
GO:0019901 (enables) protein kinase binding
GO:0034713 (enables) type I transforming growth factor beta receptor binding
GO:0046332 (enables) SMAD binding
GO:0051015 (enables) actin filament binding
GO:0007155 (involved in) cell adhesion
GO:0007160 (involved in) cell-matrix adhesion
GO:0007179 (involved in) transforming growth factor beta receptor signaling pathway
GO:0007229 (involved in) integrin-mediated signaling pathway
GO:0008360 (involved in) regulation of cell shape
GO:0010718 (involved in) positive regulation of epithelial to mesenchymal transition
GO:0016055 (involved in) Wnt signaling pathway
GO:0022604 (involved in) regulation of cell morphogenesis
GO:0030335 (involved in) positive regulation of cell migration
GO:0033622 (involved in) integrin activation
GO:0033625 (involved in) positive regulation of integrin activation
GO:0034334 (involved in) adherens junction maintenance
GO:0034446 (involved in) substrate adhesion-dependent cell spreading
GO:0035505 (involved in) positive regulation of myosin light chain kinase activity
GO:0043116 (involved in) negative regulation of vascular permeability
GO:0043547 (involved in) positive regulation of GTPase activity
GO:0045599 (involved in) negative regulation of fat cell differentiation
GO:0045669 (involved in) positive regulation of osteoblast differentiation
GO:0048041 (involved in) focal adhesion assembly
GO:0051496 (involved in) positive regulation of stress fiber assembly
GO:0051894 (involved in) positive regulation of focal adhesion assembly
GO:0051897 (involved in) positive regulation of protein kinase B signaling
GO:0060173 (involved in) limb development
GO:0060548 (involved in) negative regulation of cell death
GO:0070374 (involved in) positive regulation of ERK1 and ERK2 cascade
GO:0072657 (involved in) protein localization to membrane
GO:1900026 (involved in) positive regulation of substrate adhesion-dependent cell spreading
GO:1900182 (involved in) positive regulation of protein localization to nucleus
GO:1902462 (involved in) positive regulation of mesenchymal stem cell proliferation
GO:1903691 (involved in) positive regulation of wound healing, spreading of epidermal cells
GO:0030055 (is active in) cell-substrate junction
GO:0001725 (located in) stress fiber
GO:0005634 (located in) nucleus
GO:0005654 (located in) nucleoplasm
GO:0005737 (located in) cytoplasm
GO:0005829 (located in) cytosol
GO:0005856 (located in) cytoskeleton
GO:0005886 (located in) plasma membrane
GO:0005925 (located in) focal adhesion
GO:0005938 (located in) cell cortex
GO:0009986 (located in) cell surface
GO:0016020 (located in) membrane
GO:0031234 (located in) extrinsic component of cytoplasmic side of plasma membrane
GO:0031258 (located in) lamellipodium membrane
GO:0031674 (located in) I band
GO:0042995 (located in) cell projection
GO:0070161 (located in) anchoring junction
GO:0005912 (part of) adherens junction
GO:0030054 (part of) cell junction

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)