Click here to access PB0246 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0246 P63000 Ras-related C3 botulinum toxin substrate 1 RAC1 MIG5, MRD48, Rac-1, TC-25, p21-Rac1 Homo_sapiens In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (By similarity).

DomainsGene Ontology
PF00071 (Ras)
GO:0030036 (acts upstream of or within) actin cytoskeleton organization
GO:0005884 (colocalizes with) actin filament
GO:0000166 (enables) nucleotide binding
GO:0003924 (enables) GTPase activity
GO:0003925 (enables) G protein activity
GO:0005515 (enables) protein binding
GO:0005525 (enables) GTP binding
GO:0016787 (enables) hydrolase activity
GO:0019899 (enables) enzyme binding
GO:0019901 (enables) protein kinase binding
GO:0031996 (enables) thioesterase binding
GO:0044877 (enables) protein-containing complex binding
GO:0051022 (enables) Rho GDP-dissociation inhibitor binding
GO:0001764 (involved in) neuron migration
GO:0001934 (involved in) positive regulation of protein phosphorylation
GO:0003376 (involved in) sphingosine-1-phosphate receptor signaling pathway
GO:0006954 (involved in) inflammatory response
GO:0007015 (involved in) actin filament organization
GO:0007155 (involved in) cell adhesion
GO:0007160 (involved in) cell-matrix adhesion
GO:0007163 (involved in) establishment or maintenance of cell polarity
GO:0007264 (involved in) small GTPase mediated signal transduction
GO:0008045 (involved in) motor neuron axon guidance
GO:0008360 (involved in) regulation of cell shape
GO:0008361 (involved in) regulation of cell size
GO:0009611 (involved in) response to wounding
GO:0009653 (involved in) anatomical structure morphogenesis
GO:0010310 (involved in) regulation of hydrogen peroxide metabolic process
GO:0010591 (involved in) regulation of lamellipodium assembly
GO:0010592 (involved in) positive regulation of lamellipodium assembly
GO:0010595 (involved in) positive regulation of endothelial cell migration
GO:0010764 (involved in) negative regulation of fibroblast migration
GO:0010811 (involved in) positive regulation of cell-substrate adhesion
GO:0016477 (involved in) cell migration
GO:0016601 (involved in) Rac protein signal transduction
GO:0030031 (involved in) cell projection assembly
GO:0030032 (involved in) lamellipodium assembly
GO:0030041 (involved in) actin filament polymerization
GO:0030334 (involved in) regulation of cell migration
GO:0030865 (involved in) cortical cytoskeleton organization
GO:0031116 (involved in) positive regulation of microtubule polymerization
GO:0031529 (involved in) ruffle organization
GO:0032707 (involved in) negative regulation of interleukin-23 production
GO:0032956 (involved in) regulation of actin cytoskeleton organization
GO:0034446 (involved in) substrate adhesion-dependent cell spreading
GO:0035025 (involved in) positive regulation of Rho protein signal transduction
GO:0035556 (involved in) intracellular signal transduction
GO:0043652 (involved in) engulfment of apoptotic cell
GO:0045428 (involved in) regulation of nitric oxide biosynthetic process
GO:0045730 (involved in) respiratory burst
GO:0048012 (involved in) hepatocyte growth factor receptor signaling pathway
GO:0048261 (involved in) negative regulation of receptor-mediated endocytosis
GO:0048870 (involved in) cell motility
GO:0051492 (involved in) regulation of stress fiber assembly
GO:0051496 (involved in) positive regulation of stress fiber assembly
GO:0051668 (involved in) localization within membrane
GO:0051894 (involved in) positive regulation of focal adhesion assembly
GO:0060071 (involved in) Wnt signaling pathway, planar cell polarity pathway
GO:0060263 (involved in) regulation of respiratory burst
GO:0071526 (involved in) semaphorin-plexin signaling pathway
GO:0090023 (involved in) positive regulation of neutrophil chemotaxis
GO:0097178 (involved in) ruffle assembly
GO:1900026 (involved in) positive regulation of substrate adhesion-dependent cell spreading
GO:1902622 (involved in) regulation of neutrophil migration
GO:0005856 (is active in) cytoskeleton
GO:0005886 (is active in) plasma membrane
GO:0005938 (is active in) cell cortex
GO:0031410 (is active in) cytoplasmic vesicle
GO:0042995 (is active in) cell projection
GO:0043197 (is active in) dendritic spine
GO:0098794 (is active in) postsynapse
GO:0098978 (is active in) glutamatergic synapse
GO:0005634 (located in) nucleus
GO:0005737 (located in) cytoplasm
GO:0005789 (located in) endoplasmic reticulum membrane
GO:0005802 (located in) trans-Golgi network
GO:0005829 (located in) cytosol
GO:0005925 (located in) focal adhesion
GO:0016020 (located in) membrane
GO:0030027 (located in) lamellipodium
GO:0030425 (located in) dendrite
GO:0030667 (located in) secretory granule membrane
GO:0032587 (located in) ruffle membrane
GO:0036464 (located in) cytoplasmic ribonucleoprotein granule
GO:0042470 (located in) melanosome
GO:0043020 (located in) NADPH oxidase complex
GO:0045202 (located in) synapse
GO:0055038 (located in) recycling endosome membrane
GO:0070062 (located in) extracellular exosome
GO:0070161 (located in) anchoring junction
GO:0101003 (located in) ficolin-1-rich granule membrane
GO:0031234 (part of) extrinsic component of cytoplasmic side of plasma membrane

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)