Click here to access PB0245 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0245 P35222 Catenin beta-1 CTNNB1 CTNNB, EVR7, MRD19, NEDSDV, armadillo Homo_sapiens Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity).

DomainsGene Ontology
PF00514 (4_Arm)
GO:0010718 (acts upstream of or within) positive regulation of epithelial to mesenchymal transition
GO:0001221 (enables) transcription coregulator binding
GO:0003682 (enables) chromatin binding
GO:0003713 (enables) transcription coactivator activity
GO:0005515 (enables) protein binding
GO:0008013 (enables) beta-catenin binding
GO:0008022 (enables) protein C-terminus binding
GO:0016922 (enables) nuclear receptor binding
GO:0019899 (enables) enzyme binding
GO:0019901 (enables) protein kinase binding
GO:0019903 (enables) protein phosphatase binding
GO:0045294 (enables) alpha-catenin binding
GO:0045296 (enables) cadherin binding
GO:0061629 (enables) RNA polymerase II-specific DNA-binding transcription factor binding
GO:0140297 (enables) DNA-binding transcription factor binding
GO:1990226 (enables) histone methyltransferase binding
GO:0000122 (involved in) negative regulation of transcription by RNA polymerase II
GO:0000165 (involved in) MAPK cascade
GO:0000209 (involved in) protein polyubiquitination
GO:0000578 (involved in) embryonic axis specification
GO:0000904 (involved in) cell morphogenesis involved in differentiation
GO:0001501 (involved in) skeletal system development
GO:0001837 (involved in) epithelial to mesenchymal transition
GO:0002052 (involved in) positive regulation of neuroblast proliferation
GO:0003266 (involved in) regulation of secondary heart field cardioblast proliferation
GO:0003338 (involved in) metanephros morphogenesis
GO:0003340 (involved in) negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007398 (involved in) ectoderm development
GO:0007403 (involved in) glial cell fate determination
GO:0007405 (involved in) neuroblast proliferation
GO:0007507 (involved in) heart development
GO:0008104 (involved in) protein localization
GO:0008283 (involved in) cell population proliferation
GO:0008284 (involved in) positive regulation of cell population proliferation
GO:0008285 (involved in) negative regulation of cell population proliferation
GO:0008543 (involved in) fibroblast growth factor receptor signaling pathway
GO:0009410 (involved in) response to xenobiotic stimulus
GO:0009948 (involved in) anterior/posterior axis specification
GO:0009950 (involved in) dorsal/ventral axis specification
GO:0009953 (involved in) dorsal/ventral pattern formation
GO:0009954 (involved in) proximal/distal pattern formation
GO:0010463 (involved in) mesenchymal cell proliferation
GO:0010468 (involved in) regulation of gene expression
GO:0010628 (involved in) positive regulation of gene expression
GO:0010629 (involved in) negative regulation of gene expression
GO:0016331 (involved in) morphogenesis of embryonic epithelium
GO:0016525 (involved in) negative regulation of angiogenesis
GO:0021819 (involved in) layer formation in cerebral cortex
GO:0021854 (involved in) hypothalamus development
GO:0022009 (involved in) central nervous system vasculogenesis
GO:0022405 (involved in) hair cycle process
GO:0030097 (involved in) hemopoiesis
GO:0030154 (involved in) cell differentiation
GO:0030182 (involved in) neuron differentiation
GO:0030217 (involved in) T cell differentiation
GO:0030316 (involved in) osteoclast differentiation
GO:0030324 (involved in) lung development
GO:0030539 (involved in) male genitalia development
GO:0030856 (involved in) regulation of epithelial cell differentiation
GO:0030858 (involved in) positive regulation of epithelial cell differentiation
GO:0030900 (involved in) forebrain development
GO:0030901 (involved in) midbrain development
GO:0030902 (involved in) hindbrain development
GO:0030997 (involved in) regulation of centriole-centriole cohesion
GO:0031016 (involved in) pancreas development
GO:0031069 (involved in) hair follicle morphogenesis
GO:0031641 (involved in) regulation of myelination
GO:0032212 (involved in) positive regulation of telomere maintenance via telomerase
GO:0032331 (involved in) negative regulation of chondrocyte differentiation
GO:0032968 (involved in) positive regulation of transcription elongation by RNA polymerase II
GO:0033077 (involved in) T cell differentiation in thymus
GO:0033234 (involved in) negative regulation of protein sumoylation
GO:0034332 (involved in) adherens junction organization
GO:0035050 (involved in) embryonic heart tube development
GO:0035112 (involved in) genitalia morphogenesis
GO:0035115 (involved in) embryonic forelimb morphogenesis
GO:0035116 (involved in) embryonic hindlimb morphogenesis
GO:0036023 (involved in) embryonic skeletal limb joint morphogenesis
GO:0036520 (involved in) astrocyte-dopaminergic neuron signaling
GO:0042127 (involved in) regulation of cell population proliferation
GO:0042129 (involved in) regulation of T cell proliferation
GO:0042475 (involved in) odontogenesis of dentin-containing tooth
GO:0042733 (involved in) embryonic digit morphogenesis
GO:0042981 (involved in) regulation of apoptotic process
GO:0043065 (involved in) positive regulation of apoptotic process
GO:0043123 (involved in) positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 (involved in) proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043410 (involved in) positive regulation of MAPK cascade
GO:0043525 (involved in) positive regulation of neuron apoptotic process
GO:0043588 (involved in) skin development
GO:0044093 (involved in) positive regulation of molecular function
GO:0044336 (involved in) canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0044338 (involved in) canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
GO:0044339 (involved in) canonical Wnt signaling pathway involved in osteoblast differentiation
GO:0045453 (involved in) bone resorption
GO:0045595 (involved in) regulation of cell differentiation
GO:0045596 (involved in) negative regulation of cell differentiation
GO:0045603 (involved in) positive regulation of endothelial cell differentiation
GO:0045667 (involved in) regulation of osteoblast differentiation
GO:0045669 (involved in) positive regulation of osteoblast differentiation
GO:0045670 (involved in) regulation of osteoclast differentiation
GO:0045671 (involved in) negative regulation of osteoclast differentiation
GO:0045743 (involved in) positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045892 (involved in) negative regulation of DNA-templated transcription
GO:0045893 (involved in) positive regulation of DNA-templated transcription
GO:0045944 (involved in) positive regulation of transcription by RNA polymerase II
GO:0045976 (involved in) negative regulation of mitotic cell cycle, embryonic
GO:0048469 (involved in) cell maturation
GO:0048489 (involved in) synaptic vesicle transport
GO:0048513 (involved in) animal organ development
GO:0048538 (involved in) thymus development
GO:0048568 (involved in) embryonic organ development
GO:0048599 (involved in) oocyte development
GO:0048617 (involved in) embryonic foregut morphogenesis
GO:0048643 (involved in) positive regulation of skeletal muscle tissue development
GO:0048664 (involved in) neuron fate determination
GO:0048709 (involved in) oligodendrocyte differentiation
GO:0048715 (involved in) negative regulation of oligodendrocyte differentiation
GO:0050767 (involved in) regulation of neurogenesis
GO:0050768 (involved in) negative regulation of neurogenesis
GO:0050808 (involved in) synapse organization
GO:0051091 (involved in) positive regulation of DNA-binding transcription factor activity
GO:0051145 (involved in) smooth muscle cell differentiation
GO:0051450 (involved in) myoblast proliferation
GO:0051571 (involved in) positive regulation of histone H3-K4 methylation
GO:0051884 (involved in) regulation of timing of anagen
GO:0051973 (involved in) positive regulation of telomerase activity
GO:0060066 (involved in) oviduct development
GO:0060070 (involved in) canonical Wnt signaling pathway
GO:0060173 (involved in) limb development
GO:0060439 (involved in) trachea morphogenesis
GO:0060440 (involved in) trachea formation
GO:0060441 (involved in) epithelial tube branching involved in lung morphogenesis
GO:0060479 (involved in) lung cell differentiation
GO:0060484 (involved in) lung-associated mesenchyme development
GO:0060487 (involved in) lung epithelial cell differentiation
GO:0060492 (involved in) lung induction
GO:0060742 (involved in) epithelial cell differentiation involved in prostate gland development
GO:0060767 (involved in) epithelial cell proliferation involved in prostate gland development
GO:0060769 (involved in) positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060789 (involved in) hair follicle placode formation
GO:0060916 (involved in) mesenchymal cell proliferation involved in lung development
GO:0061047 (involved in) positive regulation of branching involved in lung morphogenesis
GO:0061198 (involved in) fungiform papilla formation
GO:0061324 (involved in) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0061549 (involved in) sympathetic ganglion development
GO:0061550 (involved in) cranial ganglion development
GO:0070602 (involved in) regulation of centromeric sister chromatid cohesion
GO:0071681 (involved in) cellular response to indole-3-methanol
GO:0072033 (involved in) renal vesicle formation
GO:0072053 (involved in) renal inner medulla development
GO:0072054 (involved in) renal outer medulla development
GO:0072079 (involved in) nephron tubule formation
GO:0072089 (involved in) stem cell proliferation
GO:0072182 (involved in) regulation of nephron tubule epithelial cell differentiation
GO:0072497 (involved in) mesenchymal stem cell differentiation
GO:0090090 (involved in) negative regulation of canonical Wnt signaling pathway
GO:0090425 (involved in) acinar cell differentiation
GO:0097091 (involved in) synaptic vesicle clustering
GO:0097190 (involved in) apoptotic signaling pathway
GO:0098609 (involved in) cell-cell adhesion
GO:1901215 (involved in) negative regulation of neuron death
GO:1903204 (involved in) negative regulation of oxidative stress-induced neuron death
GO:1904796 (involved in) regulation of core promoter binding
GO:1904798 (involved in) positive regulation of core promoter binding
GO:1904888 (involved in) cranial skeletal system development
GO:1904948 (involved in) midbrain dopaminergic neuron differentiation
GO:1904954 (involved in) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:1990138 (involved in) neuron projection extension
GO:1990403 (involved in) embryonic brain development
GO:1990791 (involved in) dorsal root ganglion development
GO:2000017 (involved in) positive regulation of determination of dorsal identity
GO:2000179 (involved in) positive regulation of neural precursor cell proliferation
GO:2000288 (involved in) positive regulation of myoblast proliferation
GO:2000648 (involved in) positive regulation of stem cell proliferation
GO:2001234 (involved in) negative regulation of apoptotic signaling pathway
GO:0000791 (located in) euchromatin
GO:0005634 (located in) nucleus
GO:0005654 (located in) nucleoplasm
GO:0005737 (located in) cytoplasm
GO:0005813 (located in) centrosome
GO:0005829 (located in) cytosol
GO:0005886 (located in) plasma membrane
GO:0005911 (located in) cell-cell junction
GO:0005912 (located in) adherens junction
GO:0005916 (located in) fascia adherens
GO:0005923 (located in) bicellular tight junction
GO:0005925 (located in) focal adhesion
GO:0014704 (located in) intercalated disc
GO:0016020 (located in) membrane
GO:0016323 (located in) basolateral plasma membrane
GO:0016327 (located in) apicolateral plasma membrane
GO:0016328 (located in) lateral plasma membrane
GO:0030018 (located in) Z disc
GO:0030027 (located in) lamellipodium
GO:0030054 (located in) cell junction
GO:0031253 (located in) cell projection membrane
GO:0031528 (located in) microvillus membrane
GO:0042734 (located in) presynaptic membrane
GO:0043296 (located in) apical junction complex
GO:0045177 (located in) apical part of cell
GO:0045202 (located in) synapse
GO:0045211 (located in) postsynaptic membrane
GO:0048471 (located in) perinuclear region of cytoplasm
GO:0070062 (located in) extracellular exosome
GO:0098685 (located in) Schaffer collateral - CA1 synapse
GO:0098831 (located in) presynaptic active zone cytoplasmic component
GO:0099092 (located in) postsynaptic density, intracellular component
GO:0005667 (part of) transcription regulator complex
GO:0016342 (part of) catenin complex
GO:0016600 (part of) flotillin complex
GO:0030877 (part of) beta-catenin destruction complex
GO:0032991 (part of) protein-containing complex
GO:0034750 (part of) Scrib-APC-beta-catenin complex
GO:0070369 (part of) beta-catenin-TCF7L2 complex
GO:0090575 (part of) RNA polymerase II transcription regulator complex
GO:1990711 (part of) beta-catenin-ICAT complex
GO:1990907 (part of) beta-catenin-TCF complex
GO:1990909 (part of) Wnt signalosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)