Click here to access PB0243 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0243 P13611 Versican core protein VCAN CSPG2, ERVR, GHAP, PG-M, WGN, WGN1 Homo_sapiens May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

DomainsGene Ontology
PF00008 (2_EGF)
PF00059 (Lectin_C)
PF00084 (Sushi)
PF00193 (2_Xlink)
PF07686 (V-set)
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0005539 (enables) glycosaminoglycan binding
GO:0005540 (enables) hyaluronic acid binding
GO:0030021 (enables) extracellular matrix structural constituent conferring compression resistance
GO:0030246 (enables) carbohydrate binding
GO:0001501 (involved in) skeletal system development
GO:0001649 (involved in) osteoblast differentiation
GO:0007155 (involved in) cell adhesion
GO:0007417 (involved in) central nervous system development
GO:0008037 (involved in) cell recognition
GO:0001750 (located in) photoreceptor outer segment
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005796 (located in) Golgi lumen
GO:0012505 (located in) endomembrane system
GO:0016020 (located in) membrane
GO:0031012 (located in) extracellular matrix
GO:0033165 (located in) interphotoreceptor matrix
GO:0042995 (located in) cell projection
GO:0043202 (located in) lysosomal lumen
GO:0062023 (located in) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)