Click here to access PB0241 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0241 A1X283 SH3 and PX domain-containing protein 2B SH3PXD2B FAD49, FTHS, HOFI, KIAA1295, TKS4, TSK4, SH3 and PX domains 2B Homo_sapiens Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity).

DomainsGene Ontology
PF00018 (3_SH3_1)
PF00787 (PX)
PF07653 (SH3_2)
GO:0005515 (enables) protein binding
GO:0010314 (enables) phosphatidylinositol-5-phosphate binding
GO:0016176 (enables) superoxide-generating NADPH oxidase activator activity
GO:0032266 (enables) phosphatidylinositol-3-phosphate binding
GO:0035091 (enables) phosphatidylinositol binding
GO:0042169 (enables) SH2 domain binding
GO:0080025 (enables) phosphatidylinositol-3,5-bisphosphate binding
GO:0001501 (involved in) skeletal system development
GO:0001654 (involved in) eye development
GO:0006801 (involved in) superoxide metabolic process
GO:0007507 (involved in) heart development
GO:0022617 (involved in) extracellular matrix disassembly
GO:0030154 (involved in) cell differentiation
GO:0042554 (involved in) superoxide anion generation
GO:0050790 (involved in) regulation of catalytic activity
GO:0060348 (involved in) bone development
GO:0060612 (involved in) adipose tissue development
GO:0071800 (involved in) podosome assembly
GO:0072657 (involved in) protein localization to membrane
GO:0002102 (located in) podosome
GO:0005737 (located in) cytoplasm
GO:0042995 (located in) cell projection
GO:0070161 (located in) anchoring junction

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)