Click here to access PB0240 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0240 P36952 Serpin B5 SERPINB5 PI5, maspin, serpin family B member 5 Homo_sapiens Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

DomainsGene Ontology
PF00079 (Serpin)
GO:0004867 (enables) serine-type endopeptidase inhibitor activity
GO:0005515 (enables) protein binding
GO:0002009 (involved in) morphogenesis of an epithelium
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0030198 (involved in) extracellular matrix organization
GO:0050678 (involved in) regulation of epithelial cell proliferation
GO:0060512 (involved in) prostate gland morphogenesis
GO:0005615 (is active in) extracellular space
GO:0001533 (located in) cornified envelope
GO:0005576 (located in) extracellular region
GO:0005737 (located in) cytoplasm
GO:0016528 (located in) sarcoplasm

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)