Click here to access PB0239 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0239 Q13162 Peroxiredoxin-4 PRDX4 AOE37-2, AOE372, HEL-S-97n, PRX-4 Homo_sapiens Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.

DomainsGene Ontology
PF00578 (AhpC-TSA)
PF10417 (1-cysPrx_C)
GO:0004601 (enables) peroxidase activity
GO:0005515 (enables) protein binding
GO:0008379 (enables) thioredoxin peroxidase activity
GO:0016209 (enables) antioxidant activity
GO:0016491 (enables) oxidoreductase activity
GO:0042802 (enables) identical protein binding
GO:0051920 (enables) peroxiredoxin activity
GO:0006979 (involved in) response to oxidative stress
GO:0007252 (involved in) I-kappaB phosphorylation
GO:0007283 (involved in) spermatogenesis
GO:0008584 (involved in) male gonad development
GO:0018401 (involved in) peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0022417 (involved in) protein maturation by protein folding
GO:0030198 (involved in) extracellular matrix organization
GO:0045454 (involved in) cell redox homeostasis
GO:0072593 (involved in) reactive oxygen species metabolic process
GO:0098869 (involved in) cellular oxidant detoxification
GO:2000255 (involved in) negative regulation of male germ cell proliferation
GO:0005576 (located in) extracellular region
GO:0005634 (located in) nucleus
GO:0005737 (located in) cytoplasm
GO:0005783 (located in) endoplasmic reticulum
GO:0005829 (located in) cytosol
GO:0034774 (located in) secretory granule lumen
GO:0070062 (located in) extracellular exosome
GO:1904813 (located in) ficolin-1-rich granule lumen

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)