Click here to access PB0238 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0238 P00747 Plasminogen PLG HAE4 Homo_sapiens Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.

DomainsGene Ontology
PF00024 (PAN_1)
PF00051 (5_Kringle)
PF00089 (Trypsin)
GO:0004175 (enables) endopeptidase activity
GO:0004252 (enables) serine-type endopeptidase activity
GO:0005102 (enables) signaling receptor binding
GO:0005515 (enables) protein binding
GO:0008233 (enables) peptidase activity
GO:0008236 (enables) serine-type peptidase activity
GO:0016787 (enables) hydrolase activity
GO:0019899 (enables) enzyme binding
GO:0019900 (enables) kinase binding
GO:0019904 (enables) protein domain specific binding
GO:0034185 (enables) apolipoprotein binding
GO:0051087 (enables) chaperone binding
GO:1990405 (enables) protein antigen binding
GO:0006508 (involved in) proteolysis
GO:0007596 (involved in) blood coagulation
GO:0007599 (involved in) hemostasis
GO:0008285 (involved in) negative regulation of cell population proliferation
GO:0010812 (involved in) negative regulation of cell-substrate adhesion
GO:0022617 (involved in) extracellular matrix disassembly
GO:0042246 (involved in) tissue regeneration
GO:0042730 (involved in) fibrinolysis
GO:0045445 (involved in) myoblast differentiation
GO:0046716 (involved in) muscle cell cellular homeostasis
GO:0048771 (involved in) tissue remodeling
GO:0051702 (involved in) biological process involved in interaction with symbiont
GO:0051918 (involved in) negative regulation of fibrinolysis
GO:0051919 (involved in) positive regulation of fibrinolysis
GO:0060707 (involved in) trophoblast giant cell differentiation
GO:0060716 (involved in) labyrinthine layer blood vessel development
GO:0071674 (involved in) mononuclear cell migration
GO:0099183 (involved in) trans-synaptic signaling by BDNF, modulating synaptic transmission
GO:2000048 (involved in) negative regulation of cell-cell adhesion mediated by cadherin
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005886 (located in) plasma membrane
GO:0009986 (located in) cell surface
GO:0019897 (located in) extrinsic component of plasma membrane
GO:0031093 (located in) platelet alpha granule lumen
GO:0031232 (located in) extrinsic component of external side of plasma membrane
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle
GO:0098685 (located in) Schaffer collateral - CA1 synapse
GO:0098978 (located in) glutamatergic synapse
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)