Click here to access PB0237 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0237 P13796 Plastin-2 LCP1 CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2, lymphocyte cytosolic protein 1 Homo_sapiens Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403).

DomainsGene Ontology
PF00307 (4_CH)
PF13499 (EF-hand_7)
GO:0001725 (colocalizes with) stress fiber
GO:0003779 (enables) actin binding
GO:0005178 (enables) integrin binding
GO:0005509 (enables) calcium ion binding
GO:0046872 (enables) metal ion binding
GO:0051015 (enables) actin filament binding
GO:0051020 (enables) GTPase binding
GO:0002286 (involved in) T cell activation involved in immune response
GO:0010737 (involved in) protein kinase A signaling
GO:0016477 (involved in) cell migration
GO:0022617 (involved in) extracellular matrix disassembly
GO:0030866 (involved in) cortical actin cytoskeleton organization
GO:0031100 (involved in) animal organ regeneration
GO:0033157 (involved in) regulation of intracellular protein transport
GO:0051017 (involved in) actin filament bundle assembly
GO:0051639 (involved in) actin filament network formation
GO:0051764 (involved in) actin crosslink formation
GO:0071803 (involved in) positive regulation of podosome assembly
GO:0001726 (located in) ruffle
GO:0001891 (located in) phagocytic cup
GO:0002102 (located in) podosome
GO:0005615 (located in) extracellular space
GO:0005737 (located in) cytoplasm
GO:0005829 (located in) cytosol
GO:0005856 (located in) cytoskeleton
GO:0005884 (located in) actin filament
GO:0005886 (located in) plasma membrane
GO:0005925 (located in) focal adhesion
GO:0015629 (located in) actin cytoskeleton
GO:0016020 (located in) membrane
GO:0030054 (located in) cell junction
GO:0030175 (located in) filopodium
GO:0032432 (located in) actin filament bundle
GO:0032587 (located in) ruffle membrane
GO:0042995 (located in) cell projection
GO:0070062 (located in) extracellular exosome
GO:0070161 (located in) anchoring junction
GO:0097386 (located in) glial cell projection
GO:0048471 (part of) perinuclear region of cytoplasm

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)