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PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0235 P06756 Integrin alpha-V ITGAV CD51, MSK8, VNRA, VTNR Homo_sapiens The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415).

DomainsGene Ontology
PF00357 (Integrin_alpha)
PF01839 (3_FG-GAP)
PF08441 (Integrin_alpha2)
GO:1905598 (acts upstream of or within) negative regulation of low-density lipoprotein receptor activity
GO:0001846 (contributes to) opsonin binding
GO:0005080 (contributes to) protein kinase C binding
GO:0017134 (contributes to) fibroblast growth factor binding
GO:0019960 (contributes to) C-X3-C chemokine binding
GO:0031994 (contributes to) insulin-like growth factor I binding
GO:0038132 (contributes to) neuregulin binding
GO:0001618 (enables) virus receptor activity
GO:0001968 (enables) fibronectin binding
GO:0002020 (enables) protease binding
GO:0005102 (enables) signaling receptor binding
GO:0005178 (enables) integrin binding
GO:0005245 (enables) voltage-gated calcium channel activity
GO:0005515 (enables) protein binding
GO:0015026 (enables) coreceptor activity
GO:0046872 (enables) metal ion binding
GO:0050431 (enables) transforming growth factor beta binding
GO:0050840 (enables) extracellular matrix binding
GO:1990430 (enables) extracellular matrix protein binding
GO:0001525 (involved in) angiogenesis
GO:0001568 (involved in) blood vessel development
GO:0001570 (involved in) vasculogenesis
GO:0007155 (involved in) cell adhesion
GO:0007160 (involved in) cell-matrix adhesion
GO:0007204 (involved in) positive regulation of cytosolic calcium ion concentration
GO:0007229 (involved in) integrin-mediated signaling pathway
GO:0008284 (involved in) positive regulation of cell population proliferation
GO:0010745 (involved in) negative regulation of macrophage derived foam cell differentiation
GO:0010888 (involved in) negative regulation of lipid storage
GO:0016477 (involved in) cell migration
GO:0030335 (involved in) positive regulation of cell migration
GO:0031589 (involved in) cell-substrate adhesion
GO:0032369 (involved in) negative regulation of lipid transport
GO:0033627 (involved in) cell adhesion mediated by integrin
GO:0033690 (involved in) positive regulation of osteoblast proliferation
GO:0034113 (involved in) heterotypic cell-cell adhesion
GO:0034446 (involved in) substrate adhesion-dependent cell spreading
GO:0035987 (involved in) endodermal cell differentiation
GO:0038027 (involved in) apolipoprotein A-I-mediated signaling pathway
GO:0043277 (involved in) apoptotic cell clearance
GO:0045785 (involved in) positive regulation of cell adhesion
GO:0046718 (involved in) viral entry into host cell
GO:0050748 (involved in) negative regulation of lipoprotein metabolic process
GO:0050764 (involved in) regulation of phagocytosis
GO:0050919 (involved in) negative chemotaxis
GO:0051057 (involved in) positive regulation of small GTPase mediated signal transduction
GO:0070371 (involved in) ERK1 and ERK2 cascade
GO:0070588 (involved in) calcium ion transmembrane transport
GO:0071604 (involved in) transforming growth factor beta production
GO:0085017 (involved in) entry into host cell by a symbiont-containing vacuole
GO:0097192 (involved in) extrinsic apoptotic signaling pathway in absence of ligand
GO:0098609 (involved in) cell-cell adhesion
GO:1901388 (involved in) regulation of transforming growth factor beta activation
GO:1902533 (involved in) positive regulation of intracellular signal transduction
GO:2000536 (involved in) negative regulation of entry of bacterium into host cell
GO:2001237 (involved in) negative regulation of extrinsic apoptotic signaling pathway
GO:0005829 (located in) cytosol
GO:0005886 (located in) plasma membrane
GO:0005887 (located in) integral component of plasma membrane
GO:0005925 (located in) focal adhesion
GO:0009897 (located in) external side of plasma membrane
GO:0009986 (located in) cell surface
GO:0016020 (located in) membrane
GO:0016021 (located in) integral component of membrane
GO:0031258 (located in) lamellipodium membrane
GO:0031527 (located in) filopodium membrane
GO:0031528 (located in) microvillus membrane
GO:0032587 (located in) ruffle membrane
GO:0035579 (located in) specific granule membrane
GO:0045335 (located in) phagocytic vesicle
GO:0070062 (located in) extracellular exosome
GO:0070161 (located in) anchoring junction
GO:0008305 (part of) integrin complex
GO:0034683 (part of) integrin alphav-beta3 complex
GO:0034684 (part of) integrin alphav-beta5 complex
GO:0034685 (part of) integrin alphav-beta6 complex
GO:0034686 (part of) integrin alphav-beta8 complex
GO:0035866 (part of) alphav-beta3 integrin-PKCalpha complex
GO:0035867 (part of) alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0035868 (part of) alphav-beta3 integrin-HMGB1 complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)