Click here to access PB0232 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0232 P02671 Fibrinogen alpha chain FGA Fib2 Homo_sapiens Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

DomainsGene Ontology
PF00147 (Fibrinogen_C)
PF08702 (Fib_alpha)
PF12160 (Fibrinogen_aC)
GO:0005102 (contributes to) signaling receptor binding
GO:0050839 (contributes to) cell adhesion molecule binding
GO:0005198 (enables) structural molecule activity
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0046872 (enables) metal ion binding
GO:0002250 (involved in) adaptive immune response
GO:0002376 (involved in) immune system process
GO:0007160 (involved in) cell-matrix adhesion
GO:0007596 (involved in) blood coagulation
GO:0007599 (involved in) hemostasis
GO:0030168 (involved in) platelet activation
GO:0031639 (involved in) plasminogen activation
GO:0034116 (involved in) positive regulation of heterotypic cell-cell adhesion
GO:0042730 (involved in) fibrinolysis
GO:0043152 (involved in) induction of bacterial agglutination
GO:0045087 (involved in) innate immune response
GO:0045907 (involved in) positive regulation of vasoconstriction
GO:0045921 (involved in) positive regulation of exocytosis
GO:0050714 (involved in) positive regulation of protein secretion
GO:0051258 (involved in) protein polymerization
GO:0051592 (involved in) response to calcium ion
GO:0065003 (involved in) protein-containing complex assembly
GO:0070374 (involved in) positive regulation of ERK1 and ERK2 cascade
GO:0070527 (involved in) platelet aggregation
GO:0072377 (involved in) blood coagulation, common pathway
GO:0072378 (involved in) blood coagulation, fibrin clot formation
GO:0090277 (involved in) positive regulation of peptide hormone secretion
GO:1900026 (involved in) positive regulation of substrate adhesion-dependent cell spreading
GO:1902042 (involved in) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000352 (involved in) negative regulation of endothelial cell apoptotic process
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005783 (located in) endoplasmic reticulum
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005886 (located in) plasma membrane
GO:0009897 (located in) external side of plasma membrane
GO:0009986 (located in) cell surface
GO:0031091 (located in) platelet alpha granule
GO:0031093 (located in) platelet alpha granule lumen
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle
GO:0110165 (located in) cellular anatomical entity
GO:1903561 (located in) extracellular vesicle
GO:0005577 (part of) fibrinogen complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)