Click here to access PB0231 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0231 P23142 Fibulin-1 FBLN1 FBLN, FIBL1 Homo_sapiens Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.

DomainsGene Ontology
PF07645 (EGF_CA)
PF12662 (3_cEGF)
GO:0062023 (colocalizes with) collagen-containing extracellular matrix
GO:0001968 (enables) fibronectin binding
GO:0005178 (enables) integrin binding
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005509 (enables) calcium ion binding
GO:0008022 (enables) protein C-terminus binding
GO:0016504 (enables) peptidase activator activity
GO:0042802 (enables) identical protein binding
GO:0044877 (enables) protein-containing complex binding
GO:0070051 (enables) fibrinogen binding
GO:0001933 (involved in) negative regulation of protein phosphorylation
GO:0007162 (involved in) negative regulation of cell adhesion
GO:0007566 (involved in) embryo implantation
GO:0010952 (involved in) positive regulation of peptidase activity
GO:0030198 (involved in) extracellular matrix organization
GO:0070373 (involved in) negative regulation of ERK1 and ERK2 cascade
GO:0072378 (involved in) blood coagulation, fibrin clot formation
GO:1900025 (involved in) negative regulation of substrate adhesion-dependent cell spreading
GO:2000146 (involved in) negative regulation of cell motility
GO:2000647 (involved in) negative regulation of stem cell proliferation
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005615 (located in) extracellular space
GO:0031012 (located in) extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0071953 (located in) elastic fiber

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)