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| PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
| PB0231 | P23142 | Fibulin-1 | FBLN1 | FBLN, FIBL1 | Homo_sapiens | Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. |
| Domains | Gene Ontology |
| PF07645 (EGF_CA) PF12662 (3_cEGF) |
GO:0062023 (colocalizes with) collagen-containing extracellular matrix
GO:0001968 (enables) fibronectin binding GO:0005178 (enables) integrin binding GO:0005201 (enables) extracellular matrix structural constituent GO:0005509 (enables) calcium ion binding GO:0008022 (enables) protein C-terminus binding GO:0016504 (enables) peptidase activator activity GO:0042802 (enables) identical protein binding GO:0044877 (enables) protein-containing complex binding GO:0070051 (enables) fibrinogen binding GO:0001933 (involved in) negative regulation of protein phosphorylation GO:0007162 (involved in) negative regulation of cell adhesion GO:0007566 (involved in) embryo implantation GO:0010952 (involved in) positive regulation of peptidase activity GO:0030198 (involved in) extracellular matrix organization GO:0070373 (involved in) negative regulation of ERK1 and ERK2 cascade GO:0072378 (involved in) blood coagulation, fibrin clot formation GO:1900025 (involved in) negative regulation of substrate adhesion-dependent cell spreading GO:2000146 (involved in) negative regulation of cell motility GO:2000647 (involved in) negative regulation of stem cell proliferation GO:0005576 (located in) extracellular region GO:0005604 (located in) basement membrane GO:0005615 (located in) extracellular space GO:0031012 (located in) extracellular matrix GO:0070062 (located in) extracellular exosome GO:0071953 (located in) elastic fiber |
| External Links | Description |
| Intact | Open source database system and analysis tools for molecular interaction data. |
| Protein Atlas | An open access resource for human proteins |
| InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |