Click here to access PB0230 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0230 P02461 Collagen alpha-1(III) chain COL3A1 EDS4A, EDSVASC, PMGEDSV, collagen type III alpha 1 chain Homo_sapiens Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.

DomainsGene Ontology
PF00093 (VWC)
PF01391 (8_Collagen)
PF01410 (COLFI)
GO:0002020 (enables) protease binding
GO:0005178 (enables) integrin binding
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0030020 (enables) extracellular matrix structural constituent conferring tensile strength
GO:0046332 (enables) SMAD binding
GO:0046872 (enables) metal ion binding
GO:0048407 (enables) platelet-derived growth factor binding
GO:0001568 (involved in) blood vessel development
GO:0001701 (involved in) in utero embryonic development
GO:0001764 (involved in) neuron migration
GO:0001894 (involved in) tissue homeostasis
GO:0002062 (involved in) chondrocyte differentiation
GO:0007160 (involved in) cell-matrix adhesion
GO:0007179 (involved in) transforming growth factor beta receptor signaling pathway
GO:0007229 (involved in) integrin-mediated signaling pathway
GO:0007507 (involved in) heart development
GO:0009314 (involved in) response to radiation
GO:0010467 (involved in) gene expression
GO:0018149 (involved in) peptide cross-linking
GO:0021819 (involved in) layer formation in cerebral cortex
GO:0021987 (involved in) cerebral cortex development
GO:0030168 (involved in) platelet activation
GO:0030198 (involved in) extracellular matrix organization
GO:0030199 (involved in) collagen fibril organization
GO:0030324 (involved in) lung development
GO:0032905 (involved in) transforming growth factor beta1 production
GO:0034097 (involved in) response to cytokine
GO:0035025 (involved in) positive regulation of Rho protein signal transduction
GO:0035264 (involved in) multicellular organism growth
GO:0035904 (involved in) aorta development
GO:0036022 (involved in) limb joint morphogenesis
GO:0042060 (involved in) wound healing
GO:0043588 (involved in) skin development
GO:0048144 (involved in) fibroblast proliferation
GO:0048251 (involved in) elastic fiber assembly
GO:0048565 (involved in) digestive tract development
GO:0048731 (involved in) system development
GO:0050777 (involved in) negative regulation of immune response
GO:0051216 (involved in) cartilage development
GO:0060350 (involved in) endochondral bone morphogenesis
GO:0060414 (involved in) aorta smooth muscle tissue morphogenesis
GO:0071230 (involved in) cellular response to amino acid stimulus
GO:0071711 (involved in) basement membrane organization
GO:0097435 (involved in) supramolecular fiber organization
GO:1990776 (involved in) response to angiotensin
GO:2001223 (involved in) negative regulation of neuron migration
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0031012 (located in) extracellular matrix
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0005581 (part of) collagen trimer
GO:0005586 (part of) collagen type III trimer

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)