Click here to access PB0229 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0229 P39060 Collagen alpha-1(XVIII) chain COL18A1 GLCC, KNO, KNO1, KS, collagen type XVIII alpha 1 chain Homo_sapiens May negatively regulate the activity of homotrimeric non-collagenous domain 1 (PubMed:11257123).

DomainsGene Ontology
PF01391 (5_Collagen)
PF01392 (Fz)
PF06121 (DUF959)
PF06482 (Endostatin)
PF20010 (Collagen_trimer)
GO:0005201 (enables) extracellular matrix structural constituent
GO:0030020 (enables) extracellular matrix structural constituent conferring tensile strength
GO:0046872 (enables) metal ion binding
GO:0001525 (involved in) angiogenesis
GO:0001886 (involved in) endothelial cell morphogenesis
GO:0007155 (involved in) cell adhesion
GO:0007601 (involved in) visual perception
GO:0008285 (involved in) negative regulation of cell population proliferation
GO:0009887 (involved in) animal organ morphogenesis
GO:0030198 (involved in) extracellular matrix organization
GO:0031012 (is active in) extracellular matrix
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005615 (located in) extracellular space
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0005581 (part of) collagen trimer

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)