Click here to access PB0228 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0228 P16070 CD44 antigen CD44 CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 Homo_sapiens Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640).

DomainsGene Ontology
PF00193 (Xlink)
GO:0004896 (contributes to) cytokine receptor activity
GO:0004888 (enables) transmembrane signaling receptor activity
GO:0005515 (enables) protein binding
GO:0005518 (enables) collagen binding
GO:0005540 (enables) hyaluronic acid binding
GO:0006954 (involved in) inflammatory response
GO:0007155 (involved in) cell adhesion
GO:0007160 (involved in) cell-matrix adhesion
GO:0016477 (involved in) cell migration
GO:0019221 (involved in) cytokine-mediated signaling pathway
GO:0030214 (involved in) hyaluronan catabolic process
GO:0033138 (involved in) positive regulation of peptidyl-serine phosphorylation
GO:0034116 (involved in) positive regulation of heterotypic cell-cell adhesion
GO:0042110 (involved in) T cell activation
GO:0043066 (involved in) negative regulation of apoptotic process
GO:0043154 (involved in) negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043518 (involved in) negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044319 (involved in) wound healing, spreading of cells
GO:0044344 (involved in) cellular response to fibroblast growth factor stimulus
GO:0050731 (involved in) positive regulation of peptidyl-tyrosine phosphorylation
GO:0051216 (involved in) cartilage development
GO:0070374 (involved in) positive regulation of ERK1 and ERK2 cascade
GO:0070487 (involved in) monocyte aggregation
GO:0098609 (involved in) cell-cell adhesion
GO:1900625 (involved in) positive regulation of monocyte aggregation
GO:1902166 (involved in) negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000392 (involved in) regulation of lamellipodium morphogenesis
GO:0016323 (is active in) basolateral plasma membrane
GO:0005794 (located in) Golgi apparatus
GO:0005829 (located in) cytosol
GO:0005886 (located in) plasma membrane
GO:0005887 (located in) integral component of plasma membrane
GO:0005902 (located in) microvillus
GO:0005925 (located in) focal adhesion
GO:0009986 (located in) cell surface
GO:0016020 (located in) membrane
GO:0016021 (located in) integral component of membrane
GO:0016324 (located in) apical plasma membrane
GO:0030667 (located in) secretory granule membrane
GO:0031258 (located in) lamellipodium membrane
GO:0042995 (located in) cell projection
GO:0070062 (located in) extracellular exosome
GO:0035692 (part of) macrophage migration inhibitory factor receptor complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)