Click here to access PB0227 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0227 P04632 Calpain small subunit 1 CAPNS1 CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1 Homo_sapiens Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity).

DomainsGene Ontology
GO:0004198 (enables) calcium-dependent cysteine-type endopeptidase activity
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0046872 (enables) metal ion binding
GO:0006508 (involved in) proteolysis
GO:0008284 (involved in) positive regulation of cell population proliferation
GO:0016241 (involved in) regulation of macroautophagy
GO:0005737 (located in) cytoplasm
GO:0005829 (located in) cytosol
GO:0005886 (located in) plasma membrane
GO:0016020 (located in) membrane
GO:0070062 (located in) extracellular exosome
GO:0110158 (located in) calpain complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)