Click here to access PB0225 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0225 P07384 Calpain-1 catalytic subunit CAPN1 CANP, CANP1, CANPL1, SPG76, muCANP, muCL Homo_sapiens Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407).

DomainsGene Ontology
PF00648 (Peptidase_C2)
PF01067 (Calpain_III)
PF13833 (EF-hand_8)
GO:0004198 (enables) calcium-dependent cysteine-type endopeptidase activity
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0008233 (enables) peptidase activity
GO:0008234 (enables) cysteine-type peptidase activity
GO:0016787 (enables) hydrolase activity
GO:0046872 (enables) metal ion binding
GO:0006508 (involved in) proteolysis
GO:0008284 (involved in) positive regulation of cell population proliferation
GO:0016241 (involved in) regulation of macroautophagy
GO:0032801 (involved in) receptor catabolic process
GO:0050790 (involved in) regulation of catalytic activity
GO:0060056 (involved in) mammary gland involution
GO:0097264 (involved in) self proteolysis
GO:2000310 (involved in) regulation of NMDA receptor activity
GO:0005737 (is active in) cytoplasm
GO:0001533 (located in) cornified envelope
GO:0005576 (located in) extracellular region
GO:0005739 (located in) mitochondrion
GO:0005764 (located in) lysosome
GO:0005829 (located in) cytosol
GO:0005886 (located in) plasma membrane
GO:0005925 (located in) focal adhesion
GO:0016020 (located in) membrane
GO:0070062 (located in) extracellular exosome
GO:1904813 (located in) ficolin-1-rich granule lumen

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)