Click here to access PB0224 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0224 P40121 Macrophage-capping protein CAPG AFCP, HEL-S-66, MCP Homo_sapiens Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.

DomainsGene Ontology
PF00626 (Gelsolin)
GO:0003779 (enables) actin binding
GO:0005515 (enables) protein binding
GO:0005546 (enables) phosphatidylinositol-4,5-bisphosphate binding
GO:0019904 (enables) protein domain specific binding
GO:0044877 (enables) protein-containing complex binding
GO:0045296 (enables) cadherin binding
GO:0051015 (enables) actin filament binding
GO:0007417 (involved in) central nervous system development
GO:0008154 (involved in) actin polymerization or depolymerization
GO:0030031 (involved in) cell projection assembly
GO:0051014 (involved in) actin filament severing
GO:0051016 (involved in) barbed-end actin filament capping
GO:0051693 (involved in) actin filament capping
GO:0065003 (involved in) protein-containing complex assembly
GO:0005615 (is active in) extracellular space
GO:0015629 (is active in) actin cytoskeleton
GO:0001726 (located in) ruffle
GO:0005634 (located in) nucleus
GO:0005654 (located in) nucleoplasm
GO:0005730 (located in) nucleolus
GO:0005737 (located in) cytoplasm
GO:0005814 (located in) centriole
GO:0030027 (located in) lamellipodium
GO:0042470 (located in) melanosome
GO:0042995 (located in) cell projection
GO:0070062 (located in) extracellular exosome
GO:0072686 (located in) mitotic spindle
GO:0090543 (located in) Flemming body
GO:0008290 (part of) F-actin capping protein complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)