Click here to access PB0223 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0223 P05067 Amyloid-beta precursor protein APP AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, alpha-sAPP, preA4 Homo_sapiens Chelation of metal ions, notably copper, iron and zinc, can induce histidine-bridging between amyloid-beta molecules resulting in amyloid-beta-metal aggregates. The affinity for copper is much higher than for other transient metals and is increased under acidic conditions. Extracellular zinc-binding increases binding of heparin to APP and inhibits collagen-binding.

DomainsGene Ontology
PF00014 (Kunitz_BPTI)
PF02177 (APP_N)
PF03494 (Beta-APP)
PF10515 (APP_amyloid)
PF12924 (APP_Cu_bd)
PF12925 (APP_E2)
GO:0000978 (enables) RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003677 (enables) DNA binding
GO:0004867 (enables) serine-type endopeptidase inhibitor activity
GO:0005102 (enables) signaling receptor binding
GO:0005515 (enables) protein binding
GO:0008201 (enables) heparin binding
GO:0016504 (enables) peptidase activator activity
GO:0030414 (enables) peptidase inhibitor activity
GO:0030546 (enables) signaling receptor activator activity
GO:0042802 (enables) identical protein binding
GO:0046872 (enables) metal ion binding
GO:0051425 (enables) PTB domain binding
GO:0070851 (enables) growth factor receptor binding
GO:0000086 (involved in) G2/M transition of mitotic cell cycle
GO:0000278 (involved in) mitotic cell cycle
GO:0001967 (involved in) suckling behavior
GO:0006378 (involved in) mRNA polyadenylation
GO:0006417 (involved in) regulation of translation
GO:0006468 (involved in) protein phosphorylation
GO:0006878 (involved in) cellular copper ion homeostasis
GO:0006897 (involved in) endocytosis
GO:0006915 (involved in) apoptotic process
GO:0006979 (involved in) response to oxidative stress
GO:0007155 (involved in) cell adhesion
GO:0007176 (involved in) regulation of epidermal growth factor-activated receptor activity
GO:0007219 (involved in) Notch signaling pathway
GO:0007409 (involved in) axonogenesis
GO:0007617 (involved in) mating behavior
GO:0007626 (involved in) locomotory behavior
GO:0008088 (involved in) axo-dendritic transport
GO:0008203 (involved in) cholesterol metabolic process
GO:0008285 (involved in) negative regulation of cell population proliferation
GO:0008344 (involved in) adult locomotory behavior
GO:0008542 (involved in) visual learning
GO:0009314 (involved in) response to radiation
GO:0010288 (involved in) response to lead ion
GO:0010466 (involved in) negative regulation of peptidase activity
GO:0010468 (involved in) regulation of gene expression
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0010952 (involved in) positive regulation of peptidase activity
GO:0010971 (involved in) positive regulation of G2/M transition of mitotic cell cycle
GO:0016199 (involved in) axon midline choice point recognition
GO:0016322 (involved in) neuron remodeling
GO:0016358 (involved in) dendrite development
GO:0030182 (involved in) neuron differentiation
GO:0030198 (involved in) extracellular matrix organization
GO:0030900 (involved in) forebrain development
GO:0031175 (involved in) neuron projection development
GO:0035235 (involved in) ionotropic glutamate receptor signaling pathway
GO:0040014 (involved in) regulation of multicellular organism growth
GO:0043393 (involved in) regulation of protein binding
GO:0045665 (involved in) negative regulation of neuron differentiation
GO:0045931 (involved in) positive regulation of mitotic cell cycle
GO:0045944 (involved in) positive regulation of transcription by RNA polymerase II
GO:0048669 (involved in) collateral sprouting in absence of injury
GO:0050803 (involved in) regulation of synapse structure or activity
GO:0050885 (involved in) neuromuscular process controlling balance
GO:0050890 (involved in) cognition
GO:0051124 (involved in) synaptic assembly at neuromuscular junction
GO:0051247 (involved in) positive regulation of protein metabolic process
GO:0051402 (involved in) neuron apoptotic process
GO:0051563 (involved in) smooth endoplasmic reticulum calcium ion homeostasis
GO:0070050 (involved in) neuron cellular homeostasis
GO:0070555 (involved in) response to interleukin-1
GO:0071280 (involved in) cellular response to copper ion
GO:0071287 (involved in) cellular response to manganese ion
GO:0071320 (involved in) cellular response to cAMP
GO:0071874 (involved in) cellular response to norepinephrine stimulus
GO:1990090 (involved in) cellular response to nerve growth factor stimulus
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005634 (located in) nucleus
GO:0005641 (located in) nuclear envelope lumen
GO:0005737 (located in) cytoplasm
GO:0005768 (located in) endosome
GO:0005769 (located in) early endosome
GO:0005783 (located in) endoplasmic reticulum
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005790 (located in) smooth endoplasmic reticulum
GO:0005791 (located in) rough endoplasmic reticulum
GO:0005794 (located in) Golgi apparatus
GO:0005796 (located in) Golgi lumen
GO:0005798 (located in) Golgi-associated vesicle
GO:0005829 (located in) cytosol
GO:0005886 (located in) plasma membrane
GO:0005887 (located in) integral component of plasma membrane
GO:0005905 (located in) clathrin-coated pit
GO:0005911 (located in) cell-cell junction
GO:0008021 (located in) synaptic vesicle
GO:0009986 (located in) cell surface
GO:0016020 (located in) membrane
GO:0016021 (located in) integral component of membrane
GO:0030134 (located in) COPII-coated ER to Golgi transport vesicle
GO:0030424 (located in) axon
GO:0030426 (located in) growth cone
GO:0031093 (located in) platelet alpha granule lumen
GO:0031410 (located in) cytoplasmic vesicle
GO:0031594 (located in) neuromuscular junction
GO:0031904 (located in) endosome lumen
GO:0032588 (located in) trans-Golgi network membrane
GO:0035253 (located in) ciliary rootlet
GO:0042995 (located in) cell projection
GO:0043005 (located in) neuron projection
GO:0043197 (located in) dendritic spine
GO:0043198 (located in) dendritic shaft
GO:0043204 (located in) perikaryon
GO:0044304 (located in) main axon
GO:0045121 (located in) membrane raft
GO:0045177 (located in) apical part of cell
GO:0045202 (located in) synapse
GO:0048471 (located in) perinuclear region of cytoplasm
GO:0048786 (located in) presynaptic active zone
GO:0051233 (located in) spindle midzone
GO:0055037 (located in) recycling endosome
GO:0070062 (located in) extracellular exosome
GO:0097449 (located in) astrocyte projection
GO:1990761 (located in) growth cone lamellipodium
GO:1990812 (located in) growth cone filopodium
GO:0043235 (part of) receptor complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)