Click here to access PB0222 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0222 P01023 Alpha-2-macroglobulin A2M A2MD, CPAMD5, FWP007, S863-7 Homo_sapiens Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

DomainsGene Ontology
PF00207 (A2M)
PF01835 (MG2)
PF07677 (A2M_recep)
PF07678 (TED_complement)
PF07703 (A2M_BRD)
PF17789 (MG4)
PF17791 (MG3)
GO:0062023 (colocalizes with) collagen-containing extracellular matrix
GO:0002020 (enables) protease binding
GO:0004866 (enables) endopeptidase inhibitor activity
GO:0004867 (enables) serine-type endopeptidase inhibitor activity
GO:0005102 (enables) signaling receptor binding
GO:0005515 (enables) protein binding
GO:0019838 (enables) growth factor binding
GO:0019899 (enables) enzyme binding
GO:0019959 (enables) interleukin-8 binding
GO:0019966 (enables) interleukin-1 binding
GO:0030414 (enables) peptidase inhibitor activity
GO:0042802 (enables) identical protein binding
GO:0043120 (enables) tumor necrosis factor binding
GO:0048306 (enables) calcium-dependent protein binding
GO:0048403 (enables) brain-derived neurotrophic factor binding
GO:0048406 (enables) nerve growth factor binding
GO:0001553 (involved in) luteinization
GO:0001869 (involved in) negative regulation of complement activation, lectin pathway
GO:0002438 (involved in) acute inflammatory response to antigenic stimulus
GO:0006953 (involved in) acute-phase response
GO:0007584 (involved in) response to nutrient
GO:0010037 (involved in) response to carbon dioxide
GO:0010466 (involved in) negative regulation of peptidase activity
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0034695 (involved in) response to prostaglandin E
GO:0048863 (involved in) stem cell differentiation
GO:0051384 (involved in) response to glucocorticoid
GO:1990402 (involved in) embryonic liver development
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0031093 (located in) platelet alpha granule lumen
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)