Click here to access PB0221 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0221 P19883 Follistatin FST FS Homo_sapiens Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

DomainsGene Ontology
PF07648 (3_Kazal_2)
PF09289 (FOLN)
GO:0051798 (acts upstream of or within) positive regulation of hair follicle development
GO:0005515 (enables) protein binding
GO:0038102 (enables) activin receptor antagonist activity
GO:0043395 (enables) heparan sulfate proteoglycan binding
GO:0048185 (enables) activin binding
GO:0000122 (involved in) negative regulation of transcription by RNA polymerase II
GO:0001501 (involved in) skeletal system development
GO:0002244 (involved in) hematopoietic progenitor cell differentiation
GO:0007276 (involved in) gamete generation
GO:0007389 (involved in) pattern specification process
GO:0008585 (involved in) female gonad development
GO:0030154 (involved in) cell differentiation
GO:0030509 (involved in) BMP signaling pathway
GO:0030510 (involved in) regulation of BMP signaling pathway
GO:0030857 (involved in) negative regulation of epithelial cell differentiation
GO:0031069 (involved in) hair follicle morphogenesis
GO:0032926 (involved in) negative regulation of activin receptor signaling pathway
GO:0036305 (involved in) ameloblast differentiation
GO:0042475 (involved in) odontogenesis of dentin-containing tooth
GO:0043616 (involved in) keratinocyte proliferation
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0005634 (located in) nucleus
GO:0005737 (located in) cytoplasm

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)