Click here to access PB0220 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0220 Q92765 Secreted frizzled-related protein 3 FRZB FIZ, FRE, FRP, FRZB1, SFRP3 Homo_sapiens Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

DomainsGene Ontology
PF01392 (Fz)
PF01759 (NTR)
GO:0043065 (acts upstream of or within) positive regulation of apoptotic process
GO:0045600 (acts upstream of or within) positive regulation of fat cell differentiation
GO:0005515 (enables) protein binding
GO:0017147 (enables) Wnt-protein binding
GO:0001501 (involved in) skeletal system development
GO:0002064 (involved in) epithelial cell development
GO:0008285 (involved in) negative regulation of cell population proliferation
GO:0010721 (involved in) negative regulation of cell development
GO:0014033 (involved in) neural crest cell differentiation
GO:0016055 (involved in) Wnt signaling pathway
GO:0030154 (involved in) cell differentiation
GO:0030178 (involved in) negative regulation of Wnt signaling pathway
GO:0030308 (involved in) negative regulation of cell growth
GO:0042472 (involved in) inner ear morphogenesis
GO:0048856 (involved in) anatomical structure development
GO:0050793 (involved in) regulation of developmental process
GO:0060029 (involved in) convergent extension involved in organogenesis
GO:0060070 (involved in) canonical Wnt signaling pathway
GO:0061037 (involved in) negative regulation of cartilage development
GO:0061053 (involved in) somite development
GO:0070365 (involved in) hepatocyte differentiation
GO:0070367 (involved in) negative regulation of hepatocyte differentiation
GO:0090090 (involved in) negative regulation of canonical Wnt signaling pathway
GO:0090103 (involved in) cochlea morphogenesis
GO:0005737 (is active in) cytoplasm
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0016020 (located in) membrane

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)