Click here to access PB0219 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0219 P18065 Insulin-like growth factor-binding protein 2 IGFBP2 IBP2, IGF-BP53, BP2 Homo_sapiens Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

DomainsGene Ontology
PF00086 (Thyroglobulin_1)
PF00219 (IGFBP)
GO:0005102 (enables) signaling receptor binding
GO:0005515 (enables) protein binding
GO:0005520 (enables) insulin-like growth factor binding
GO:0019838 (enables) growth factor binding
GO:0031994 (enables) insulin-like growth factor I binding
GO:0031995 (enables) insulin-like growth factor II binding
GO:0007165 (involved in) signal transduction
GO:0007565 (involved in) female pregnancy
GO:0007568 (involved in) aging
GO:0007584 (involved in) response to nutrient
GO:0009410 (involved in) response to xenobiotic stimulus
GO:0009612 (involved in) response to mechanical stimulus
GO:0010226 (involved in) response to lithium ion
GO:0032355 (involved in) response to estradiol
GO:0032526 (involved in) response to retinoic acid
GO:0032870 (involved in) cellular response to hormone stimulus
GO:0040008 (involved in) regulation of growth
GO:0042104 (involved in) positive regulation of activated T cell proliferation
GO:0043567 (involved in) regulation of insulin-like growth factor receptor signaling pathway
GO:0043627 (involved in) response to estrogen
GO:0048545 (involved in) response to steroid hormone
GO:0051384 (involved in) response to glucocorticoid
GO:0090090 (involved in) negative regulation of canonical Wnt signaling pathway
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0016324 (located in) apical plasma membrane
GO:0031410 (located in) cytoplasmic vesicle
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)