PB0218

DATABASE

Click here to access PB0218 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0218	P21741	Midkine	MDK	ARAP, MK, NEGF2	Homo_sapiens	In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity).

Domains

Gene Ontology

PF01091 (PTN_MK_C) PF05196 (PTN_MK_N)

GO:0062023 (colocalizes with) collagen-containing extracellular matrix GO:0005515 (enables) protein binding GO:0008083 (enables) growth factor activity GO:0008201 (enables) heparin binding GO:0035374 (enables) chondroitin sulfate binding GO:1904399 (enables) heparan sulfate binding GO:0001662 (involved in) behavioral fear response GO:0002232 (involved in) leukocyte chemotaxis involved in inflammatory response GO:0002286 (involved in) T cell activation involved in immune response GO:0002690 (involved in) positive regulation of leukocyte chemotaxis GO:0007010 (involved in) cytoskeleton organization GO:0007162 (involved in) negative regulation of cell adhesion GO:0007165 (involved in) signal transduction GO:0007399 (involved in) nervous system development GO:0007614 (involved in) short-term memory GO:0009410 (involved in) response to xenobiotic stimulus GO:0009611 (involved in) response to wounding GO:0009725 (involved in) response to hormone GO:0010667 (involved in) negative regulation of cardiac muscle cell apoptotic process GO:0010718 (involved in) positive regulation of epithelial to mesenchymal transition GO:0010759 (involved in) positive regulation of macrophage chemotaxis GO:0010838 (involved in) positive regulation of keratinocyte proliferation GO:0010976 (involved in) positive regulation of neuron projection development GO:0010996 (involved in) response to auditory stimulus GO:0016477 (involved in) cell migration GO:0021542 (involved in) dentate gyrus development GO:0021681 (involved in) cerebellar granular layer development GO:0021766 (involved in) hippocampus development GO:0021987 (involved in) cerebral cortex development GO:0030154 (involved in) cell differentiation GO:0030279 (involved in) negative regulation of ossification GO:0030325 (involved in) adrenal gland development GO:0030335 (involved in) positive regulation of cell migration GO:0030421 (involved in) defecation GO:0032330 (involved in) regulation of chondrocyte differentiation GO:0032735 (involved in) positive regulation of interleukin-12 production GO:0042246 (involved in) tissue regeneration GO:0043524 (involved in) negative regulation of neuron apoptotic process GO:0044849 (involved in) estrous cycle GO:0045582 (involved in) positive regulation of T cell differentiation GO:0045590 (involved in) negative regulation of regulatory T cell differentiation GO:0045785 (involved in) positive regulation of cell adhesion GO:0045893 (involved in) positive regulation of DNA-templated transcription GO:0046850 (involved in) regulation of bone remodeling GO:0048477 (involved in) oogenesis GO:0048714 (involved in) positive regulation of oligodendrocyte differentiation GO:0050729 (involved in) positive regulation of inflammatory response GO:0050795 (involved in) regulation of behavior GO:0050896 (involved in) response to stimulus GO:0051384 (involved in) response to glucocorticoid GO:0051781 (involved in) positive regulation of cell division GO:0061036 (involved in) positive regulation of cartilage development GO:0071673 (involved in) positive regulation of smooth muscle cell chemotaxis GO:0090023 (involved in) positive regulation of neutrophil chemotaxis GO:0090090 (involved in) negative regulation of canonical Wnt signaling pathway GO:0106015 (involved in) negative regulation of inflammatory response to wounding GO:0106016 (involved in) positive regulation of inflammatory response to wounding GO:0106091 (involved in) glial cell projection elongation GO:1900026 (involved in) positive regulation of substrate adhesion-dependent cell spreading GO:1901215 (involved in) negative regulation of neuron death GO:1903039 (involved in) positive regulation of leukocyte cell-cell adhesion GO:1904036 (involved in) negative regulation of epithelial cell apoptotic process GO:1904996 (involved in) positive regulation of leukocyte adhesion to vascular endothelial cell GO:1905555 (involved in) positive regulation of blood vessel branching GO:1905564 (involved in) positive regulation of vascular endothelial cell proliferation GO:1905653 (involved in) positive regulation of artery morphogenesis GO:2000179 (involved in) positive regulation of neural precursor cell proliferation GO:2000249 (involved in) regulation of actin cytoskeleton reorganization GO:2000347 (involved in) positive regulation of hepatocyte proliferation GO:2000391 (involved in) positive regulation of neutrophil extravasation GO:2001224 (involved in) positive regulation of neuron migration GO:0005576 (located in) extracellular region GO:0005737 (located in) cytoplasm GO:0042995 (located in) cell projection

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P21741|MK_HUMAN Midkine OS=Homo sapiens OX=9606 GN=MDK PE=1 SV=1 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI RVTKPCTPKTKAKAKAKKGKGKD >sp|P21741-2|MK_HUMAN Isoform 2 of Midkine OS=Homo sapiens OX=9606 GN=MDK MQHRGFLLLTLLALLALTSAVAKKKADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQC QETIRVTKPCTPKTKAKAKAKKGKGKD >tr|Q9W767|Q9W767_DANRE Midkine a OS=Danio rerio OX=7955 GN=mdka PE=1 SV=1 MRGLFSTLLVVLVALMIVTSEAGKNKKEKNKGGKGGADCAEWLYGSCVANNGDCGQGMRE GTCNEQTRKVKCRVPCNWKKEFGADCKYKFGNWGECDAATSTKSRTGTLQKALFNVECQQ TVSVTKPCTTKVKNKPKGKKGKGKGN >tr|Q9DDG2|Q9DDG2_DANRE Midkine b OS=Danio rerio OX=7955 GN=mdkb PE=1 SV=1 MRSLFSIALVLVVVSMITVEASMKKKEKGKEPKADAECSEWQYGKCVPNSGDCGNGIREA TCNEQTKKTKCKVPCNWKKDFGADCKYKFGRWAECDTTTGTRSRSGTLKKALFNAECQTT IKVSKPCTPKTPKPKGGEKKKGKGKEN
Selected proteins from model organisms >sp|P21741|MK_HUMAN Midkine OS=Homo sapiens OX=9606 GN=MDK PE=1 SV=1 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI RVTKPCTPKTKAKAKAKKGKGKD >sp|P21741-2|MK_HUMAN Isoform 2 of Midkine OS=Homo sapiens OX=9606 GN=MDK MQHRGFLLLTLLALLALTSAVAKKKADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQC QETIRVTKPCTPKTKAKAKAKKGKGKD >tr|Q9W767|Q9W767_DANRE Midkine a OS=Danio rerio OX=7955 GN=mdka PE=1 SV=1 MRGLFSTLLVVLVALMIVTSEAGKNKKEKNKGGKGGADCAEWLYGSCVANNGDCGQGMRE GTCNEQTRKVKCRVPCNWKKEFGADCKYKFGNWGECDAATSTKSRTGTLQKALFNVECQQ TVSVTKPCTTKVKNKPKGKKGKGKGN >tr|Q9DDG2|Q9DDG2_DANRE Midkine b OS=Danio rerio OX=7955 GN=mdkb PE=1 SV=1 MRSLFSIALVLVVVSMITVEASMKKKEKGKEPKADAECSEWQYGKCVPNSGDCGNGIREA TCNEQTKKTKCKVPCNWKKDFGADCKYKFGRWAECDTTTGTRSRSGTLKKALFNAECQTT IKVSKPCTPKTPKPKGGEKKKGKGKEN >NP_001012336.1 midkine isoform a precursor [Mus musculus] MQHRGFFLLALLALLVVTSAVAKKKEKVKKGSECSEWTWGPCTPSSKDCGMGFREGTCGAQTQRVHCKVP CNWKKEFGADCKYKFESWGACDGSTGTKARQGTLKKARYNAQCQETIRVTKPCTSKTKSKTKAKKGKGKD >XP_006234653.1 midkine isoform X1 [Rattus norvegicus] MRMQHRSFFLLALVALLAVTTAVAKKKDKVKKGSECSEWTWGPCTPSSKDCGMGFREGTCGAQTQRIHCK VPCNWKKEFGADCKYKFESWGACDGSTGTKARQGTLKKARYNAQCQETIRVTKPCTSKTKSKAKAKKGKG KD >XP_005216459.1 midkine isoform X1 [Bos taurus] MPEDPAHKRMQRRSFLLLALLALLALTSAVAKKKDKMKKGGPGSECAEWTWGPCTPSSKDCGVGFREGTC GAQTQRIRCRVPCNWKKEFGADCKYKFETWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTK AKAKAKKGKEKD >NP_001106760.1 midkine precursor [Gallus gallus] MQPRGLLLLLALLLLAAAAEAAKAKKEKMKKEGSECQDWHWGPCIPNSKDCGLGYREGSCGDESRKLKCK IPCNWKKKFGADCKYKFERWGGGSAKTGVKTRSGILKKALYNAECEEVVYVSKPCTAKMKAKAKAKKGKG KD >XP_016776261.1 midkine [Pan troglodytes] MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRC RVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGK GKD >NP_001075636.1 midkine precursor [Oryctolagus cuniculus] MQHRGVLLLTLLALLALTSAVAKKKDKVKGGPGSECAEWTWGPCTPSSKDCGVGFREGTCGAQTQRIRCR LPCNWKKEFGADCKYKFDSWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKA KD >XP_005660995.1 midkine isoform X1 [Sus scrofa] MQRRGFLLLALFALLALTDAVAKKKDKVKKGGPGSECAEWTWGPCTPSSKDCGVGFREGTCGAQTQRVRC RVPCNWKKEFGADCKYKFESWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKASFLT HSSPGGQQGRGGSAHFSAKKGKGKD >XP_003206471.1 midkine [Meleagris gallopavo] MQPRALLLLLALLLLAATAEAVKAKKEKAKKEGSECQDWRWGPCVPNSKDCGLGYREGTCGDESRKLKCK IPCNWKKKFGADCKYKFESWGGCSAQTGVKTRSGILKKALYNAQCEEVVYVSKPCAAKMKAKAKAKKGKG KD >XP_003815262.2 midkine [Pan paniscus] MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRC RVPCNWKKEFGADCKYKFENWGACDGGTSTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGK GKD >XP_023095580.1 midkine [Felis catus] MQHRGFLLLALFTLLALTTAVAKKKDKVKKGGPGNECAEWTWGPCTPSSKDCGVGFREGTCGAQTQRVRC RVPCNWKKEFGADCKYKFESWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGK GKD >XP_004016486.3 midkine isoform X1 [Ovis aries] MPEVPAHKRMQRRSFLLLALLALLALTSAVAKKKDKVKKGGLGSECAEWTWGPCTPSSKDCGVGFREGTC GAQTQRIRCRVPCNWKKEFGADCKYKFETWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTK AKAKAKKGKEKD >XP_004051063.1 midkine [Gorilla gorilla gorilla] MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRC RVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGK GKD >XP_005502241.1 midkine [Columba livia] MQVQGLLLLLALILLAATAEAGKNKKEKVKKDGSECEDWRWGPCVPNSKDCGLGYREGTCKDESKKLKCK IPCNWKKKFGADCKYKFESWGGCSAQTGVKTRSGVLKKALYNAQCEEIVYVTKPCSSKIKSKSKAKKGKG KD >XP_006026987.1 midkine isoform X1 [Alligator sinensis] MQVRGLLLLMVLIIIAATSEAGKNKKDKVKKNGSECEEWHWGSCVPNSRDCGLGYREGTCKEETKRVKCK IPCNWKKEFGADCKYKFENWTGCNVQTGFKTRSGTLKKALYNAQCQDTILVTKPCSPKIKSKSKVRKGKG KE >XP_014457641.1 PREDICTED: midkine [Alligator mississippiensis] MQVRGLLLLMVLIIIAATSEAGKNKKDKVKKNGSECEEWHWGSCVPNSKDCGLGYREGTCKEETKRVKCK IPCNWKKEFGADCKYKFENWTGCNVQTGFKTRSGTLKKALYNAQCQDTILVTKPCSPKIKSKSKARKGKG KE >XP_024110593.1 midkine isoform X1 [Pongo abelii] MPQAQGQRGWALAAAAVARSGTSQTAPVSAKFHQIQACGLLPQDPHSQSLKPVLPERHWATAPVAFSGGL GPRLPPAQQSAFLPTRGNGPRMQHRGFLLLTFLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSS KDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQET IRVTKPCTPKTKAKAKAKKGKGKD >XP_017914647.1 PREDICTED: midkine isoform X1 [Capra hircus] MPEVPAHKRMQRRSFLLLALLALLALTSAVAKKKDKVKKGGLGSECAEWTWGPCTPSSKDCGVGFREGTC GAQTQRIRCRVPCNWKKEFGADCKYKFETWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTK AKAKAKKGKEKD >XP_020737487.1 midkine isoform X1 [Odocoileus virginianus texanus] MLAVPAHKGMQRRSFLLLAFLALLALTSAVAKKKDKVKKGGPGSECAEWTWGPCTPSSKDCGVGFREGTC GAQTQRIRCRVPCNWKKEFGADCKYKFETWGACDGTGTRARQGTLKKARHNAQCQGTVRVTKPCSPKAKA KAKASFLSPGSPGGQPGRGAYAHFSAKKGKEKD >XP_038280452.1 midkine isoform X1 [Canis lupus familiaris] MKVKERMQLRGFLLLALLTLLALPAAVAKKKDKVKKGGPGSECAEWTWGPCTPSSKDCGVGFREGTCGAQ TQRIRCRVPCNWKKEFGADCKYKFENWGACDGGSGTKARQGTLKKARYNAQCQETIRVTKPCTPKTKAKA KAKKGKGKD >XP_040184121.1 midkine [Rana temporaria] MELRALCVIVLVAILAVSSQAAKKKDKGKKGGSDCSEWKWSPCVPNSKDCGVGTREGTCKEETSKLKCKI PCNWKKPFGADCKYKFNNWGECNTETNVKSRTGTLKKALYNAECQQTVEATKPCSVKVKTKSKGKKGKGK D >XP_043337057.1 midkine isoform X1 [Cervus canadensis] MPEVPAHKGMQRRSFLLLALLALLALTSAVAKKKDKVKKGGPGSECAEWTWGPCTPSSKDCGVGFREGTCGAQTQRIRCR VPCNWKKEFGADCKYKFETWGACDGTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTKAKAKASFLSPSSPGGQPGRGA YAHFSAKKGKEKD >XP_043337059.1 midkine isoform X3 [Cervus canadensis] MQRRSFLLLALLALLALTSAVAKKKDKVKKGGPGSECAEWTWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEF GADCKYKFETWGACDGTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTKAKAKASFLSPSSPGGQPGRGAYAHFSAKKG KEKD >KAF4009423.1 hypothetical protein G4228_000599 [Cervus hanglu yarkandensis] MQRRSFLLLALLALLALTSAVAKKKDKVKKGGPGSECAEWTWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEF GADCKYKFETWGACDGTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTKAKAKASFLSPSSPGGQPGRGAYAHFSGEGT EAVFQGCWD >NP_001084019.1 midkine-B precursor [Xenopus laevis] MELRAFCVILLITILAVSSQAAKNKKEKGKKGASDCTEWTWGSCIPNSKDCGAGTREGTCKEETRKLKCKIPCNWKKDFG ADCKYKFENWGECNATTGQKVRSGTLKKALYNADCQQTVEAAKPCSLKTKSKSKGKKGKGKE >XP_011474705.1 midkine [Oryzias latipes] MRLLLSVLLLLALALGAEANRRAKNHKGGKHDRSRPASECSLAETQFGKCVPEQGDCGEGLREATCDGRTEKIHCKIPCN WKKDISDCKYKFGQWSSCDAATNTKTRSGTLKRVLFNAECQTTVKVSKPCSPKVKKTRGEKSN >KAB0376128.1 hypothetical protein FD755_012771 [Muntiacus reevesi] MQTPQYLQQRRKFAAAFLAFIFILAVVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSGDCGLGTREGTRTGAECKQTM KTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRALHNADCQKTVTISKPCGKLTKSKPQGSENKKKYPQ KLRRID >KAB0342505.1 hypothetical protein FD754_019431 [Muntiacus muntjak] MQTPQYLQQRQKFAAAFLAFIFILAVVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSGDCGLGTREGTRTGAECKQTM KTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRALHNADCQKTVTISKPCGKLTKSKPQGTENKKKCPQ KLRRID >XP_015820563.1 PREDICTED: midkine isoform X1 [Nothobranchius furzeri] MMGRLIAITLVLFLVLTADASKRTKHHKAGKHEKSQNSECPAAETRFGKCVPDHGDCGDGLRETICRDQVEKIHCRIPCN WKKDISDCKYRFGPWGPCDTATNTKTRSGTLKRALFNAECQTTIKVSKPCSHKTKKTRGEKSSN >XP_030282376.1 midkine [Sparus aurata] MRSLLSVTLLLLLAVTLAAEASRKAKNHKGGKHDKTRPASDCPPADTQYGKCVPEHGDCGDGLRDATCKDHTDKIHCKIP CNWKKDISDCKYKFGPWGSCDAASNTKSRSGTLKRALFNADCQATVKVSKPCSPKVKKAKGDKKSN
Mafft alignment of selected proteins >sp|P21741|MK_HUMAN Midkine OS=Homo sapiens OX=9606 GN=MDK PE=1 SV=1 ------------------------------------------------------------ -------------------------------MQHRGFLLLTLLALLA--LTSAVAK-KKD KVKKGGP------GSEC--AEWAWGPCTPSSKDCGVGFREGT-----CGAQTQRIRCRVP CNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAK AK----------------------AKKGKGKD-------- >sp|P21741-2|MK_HUMAN Isoform 2 of Midkine OS=Homo sapiens OX=9606 GN=MDK ------------------------------------------------------------ -------------------------------MQHRGFLLLTLLALLA--LTSAVAK-KK- ------------------------------------------------------------ --------ADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAK AK----------------------AKKGKGKD-------- >tr|Q9W767|Q9W767_DANRE Midkine a OS=Danio rerio OX=7955 GN=mdka PE=1 SV=1 M----------------------------------------------------------- -------------------------------RGLFSTLLVVLVALMI--VTSEAGKNKKE KNKGGKG------GADC--AEWLYGSCVANNGDCGQGMREGT-----CNEQTRKVKCRVP CNWKKEFGADCKYKFGNWGECDAATSTKSRTGTLQKALFNVECQQTVSVTKPCTTKVKNK PK----------------------GKKGKGKGN------- >tr|Q9DDG2|Q9DDG2_DANRE Midkine b OS=Danio rerio OX=7955 GN=mdkb PE=1 SV=1 ------------------------------------------------------------ ---------------------------------MRSLFSIALVLVVVSMITVEASMKKKE KGKEPKA------DAEC--SEWQYGKCVPNSGDCGNGIREAT-----CNEQTKKTKCKVP CNWKKDFGADCKYKFGRWAECDTTTGTRSRSGTLKKALFNAECQTTIKVSKPCTPKTP-K PK---------GGE----------KKKGKGKEN------- >NP_001012336.1 midkine isoform a precursor [Mus musculus] ------------------------------------------------------------ -------------------------------MQHRGFFLLALLALLV--VTSAVAK-KKE KVKK---------GSEC--SEWTWGPCTPSSKDCGMGFREGT-----CGAQTQRVHCKVP CNWKKEFGADCKYKFESWGACDGSTGTKARQGTLKKARYNAQCQETIRVTKPCTSKTKSK TK----------------------AKKGKGKD-------- >XP_006234653.1 midkine isoform X1 [Rattus norvegicus] M----------------------------------------------------------- ------------------------------RMQHRSFFLLALVALLA--VTTAVAK-KKD KVKK---------GSEC--SEWTWGPCTPSSKDCGMGFREGT-----CGAQTQRIHCKVP CNWKKEFGADCKYKFESWGACDGSTGTKARQGTLKKARYNAQCQETIRVTKPCTSKTKSK AK----------------------AKKGKGKD-------- >XP_005216459.1 midkine isoform X1 [Bos taurus] M----------------------------------------------------------- -----------------------PEDPAHKRMQRRSFLLLALLALLA--LTSAVAK-KKD KMKKGGP------GSEC--AEWTWGPCTPSSKDCGVGFREGT-----CGAQTQRIRCRVP CNWKKEFGADCKYKFETWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTKAK AK----------------------AKKGKEKD-------- >NP_001106760.1 midkine precursor [Gallus gallus] ------------------------------------------------------------ -------------------------------MQPRGLLLLLALLLLA--AAAEAAKAKKE KMKKE--------GSEC--QDWHWGPCIPNSKDCGLGYREGS-----CGDESRKLKCKIP CNWKKKFGADCKYKFERWGGGSAKTGVKTRSGILKKALYNAECEEVVYVSKPCTAKMKAK AK----------------------AKKGKGKD-------- >XP_016776261.1 midkine [Pan troglodytes] ------------------------------------------------------------ -------------------------------MQHRGFLLLTLLALLA--LTSAVAK-KKD KVKKGGP------GSEC--AEWAWGPCTPSSKDCGVGFREGT-----CGAQTQRIRCRVP CNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAK AK----------------------AKKGKGKD-------- >NP_001075636.1 midkine precursor [Oryctolagus cuniculus] ------------------------------------------------------------ -------------------------------MQHRGVLLLTLLALLA--LTSAVAK-KKD KV-KGGP------GSEC--AEWTWGPCTPSSKDCGVGFREGT-----CGAQTQRIRCRLP CNWKKEFGADCKYKFDSWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCTPKTKAK AK----------------------AKKGKAKD-------- >XP_005660995.1 midkine isoform X1 [Sus scrofa] ------------------------------------------------------------ -------------------------------MQRRGFLLLALFALLA--LTDAVAK-KKD KVKKGGP------GSEC--AEWTWGPCTPSSKDCGVGFREGT-----CGAQTQRVRCRVP CNWKKEFGADCKYKFESWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCTPKTKAK AKASFLTHSSPGGQQGRGGSAHFSAKKGKGKD-------- >XP_003206471.1 midkine [Meleagris gallopavo] ------------------------------------------------------------ -------------------------------MQPRALLLLLALLLLA--ATAEAVKAKKE KAKKE--------GSEC--QDWRWGPCVPNSKDCGLGYREGT-----CGDESRKLKCKIP CNWKKKFGADCKYKFESWGGCSAQTGVKTRSGILKKALYNAQCEEVVYVSKPCAAKMKAK AK----------------------AKKGKGKD-------- >XP_003815262.2 midkine [Pan paniscus] ------------------------------------------------------------ -------------------------------MQHRGFLLLTLLALLA--LTSAVAK-KKD KVKKGGP------GSEC--AEWAWGPCTPSSKDCGVGFREGT-----CGAQTQRIRCRVP CNWKKEFGADCKYKFENWGACDGGTSTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAK AK----------------------AKKGKGKD-------- >XP_023095580.1 midkine [Felis catus] ------------------------------------------------------------ -------------------------------MQHRGFLLLALFTLLA--LTTAVAK-KKD KVKKGGP------GNEC--AEWTWGPCTPSSKDCGVGFREGT-----CGAQTQRVRCRVP CNWKKEFGADCKYKFESWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCTPKTKAK AK----------------------AKKGKGKD-------- >XP_004016486.3 midkine isoform X1 [Ovis aries] M----------------------------------------------------------- -----------------------PEVPAHKRMQRRSFLLLALLALLA--LTSAVAK-KKD KVKKGGL------GSEC--AEWTWGPCTPSSKDCGVGFREGT-----CGAQTQRIRCRVP CNWKKEFGADCKYKFETWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTKAK AK----------------------AKKGKEKD-------- >XP_004051063.1 midkine [Gorilla gorilla gorilla] ------------------------------------------------------------ -------------------------------MQHRGFLLLTLLALLA--LTSAVAK-KKD KVKKGGP------GSEC--AEWAWGPCTPSSKDCGVGFREGT-----CGAQTQRIRCRVP CNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAK AK----------------------AKKGKGKD-------- >XP_005502241.1 midkine [Columba livia] ------------------------------------------------------------ -------------------------------MQVQGLLLLLALILLA--ATAEAGKNKKE KVKKD--------GSEC--EDWRWGPCVPNSKDCGLGYREGT-----CKDESKKLKCKIP CNWKKKFGADCKYKFESWGGCSAQTGVKTRSGVLKKALYNAQCEEIVYVTKPCSSKIKSK SK----------------------AKKGKGKD-------- >XP_006026987.1 midkine isoform X1 [Alligator sinensis] ------------------------------------------------------------ -------------------------------MQVRGLLLLMVLIIIA--ATSEAGKNKKD KVKKN--------GSEC--EEWHWGSCVPNSRDCGLGYREGT-----CKEETKRVKCKIP CNWKKEFGADCKYKFENWTGCNVQTGFKTRSGTLKKALYNAQCQDTILVTKPCSPKIKSK SK----------------------VRKGKGKE-------- >XP_014457641.1 PREDICTED: midkine [Alligator mississippiensis] ------------------------------------------------------------ -------------------------------MQVRGLLLLMVLIIIA--ATSEAGKNKKD KVKKN--------GSEC--EEWHWGSCVPNSKDCGLGYREGT-----CKEETKRVKCKIP CNWKKEFGADCKYKFENWTGCNVQTGFKTRSGTLKKALYNAQCQDTILVTKPCSPKIKSK SK----------------------ARKGKGKE-------- >XP_024110593.1 midkine isoform X1 [Pongo abelii] MPQAQGQRGWALAAAAVARSGTSQTAPVSAKFHQIQACGLLPQDPHSQSLKPVLPERHWA TAPVAFSGGLGPRLPPAQQSAFLPTRGNGPRMQHRGFLLLTFLALLA--LTSAVAK-KKD KVKKGGP------GSEC--AEWAWGPCTPSSKDCGVGFREGT-----CGAQTQRIRCRVP CNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAK AK----------------------AKKGKGKD-------- >XP_017914647.1 PREDICTED: midkine isoform X1 [Capra hircus] M----------------------------------------------------------- -----------------------PEVPAHKRMQRRSFLLLALLALLA--LTSAVAK-KKD KVKKGGL------GSEC--AEWTWGPCTPSSKDCGVGFREGT-----CGAQTQRIRCRVP CNWKKEFGADCKYKFETWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTKAK AK----------------------AKKGKEKD-------- >XP_020737487.1 midkine isoform X1 [Odocoileus virginianus texanus] M----------------------------------------------------------- -----------------------LAVPAHKGMQRRSFLLLAFLALLA--LTSAVAK-KKD KVKKGGP------GSEC--AEWTWGPCTPSSKDCGVGFREGT-----CGAQTQRIRCRVP CNWKKEFGADCKYKFETWGACD-GTGTRARQGTLKKARHNAQCQGTVRVTKPCSPKAKAK AKASFLSPGSPGGQPGRGAYAHFSAKKGKEKD-------- >XP_038280452.1 midkine isoform X1 [Canis lupus familiaris] M----------------------------------------------------------- --------------------------KVKERMQLRGFLLLALLTLLA--LPAAVAK-KKD KVKKGGP------GSEC--AEWTWGPCTPSSKDCGVGFREGT-----CGAQTQRIRCRVP CNWKKEFGADCKYKFENWGACDGGSGTKARQGTLKKARYNAQCQETIRVTKPCTPKTKAK AK----------------------AKKGKGKD-------- >XP_040184121.1 midkine [Rana temporaria] ------------------------------------------------------------ -------------------------------MELRALCVIVLVAILA--VSSQAAK-KKD KGKKG--------GSDC--SEWKWSPCVPNSKDCGVGTREGT-----CKEETSKLKCKIP CNWKKPFGADCKYKFNNWGECNTETNVKSRTGTLKKALYNAECQQTVEATKPCSVKVKTK SK----------------------GKKGKGKD-------- >XP_043337057.1 midkine isoform X1 [Cervus canadensis] M----------------------------------------------------------- -----------------------PEVPAHKGMQRRSFLLLALLALLA--LTSAVAK-KKD KVKKGGP------GSEC--AEWTWGPCTPSSKDCGVGFREGT-----CGAQTQRIRCRVP CNWKKEFGADCKYKFETWGACD-GTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTKAK AKASFLSPSSPGGQPGRGAYAHFSAKKGKEKD-------- >XP_043337059.1 midkine isoform X3 [Cervus canadensis] ------------------------------------------------------------ -------------------------------MQRRSFLLLALLALLA--LTSAVAK-KKD KVKKGGP------GSEC--AEWTWGPCTPSSKDCGVGFREGT-----CGAQTQRIRCRVP CNWKKEFGADCKYKFETWGACD-GTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTKAK AKASFLSPSSPGGQPGRGAYAHFSAKKGKEKD-------- >KAF4009423.1 hypothetical protein G4228_000599 [Cervus hanglu yarkandensis] ------------------------------------------------------------ -------------------------------MQRRSFLLLALLALLA--LTSAVAK-KKD KVKKGGP------GSEC--AEWTWGPCTPSSKDCGVGFREGT-----CGAQTQRIRCRVP CNWKKEFGADCKYKFETWGACD-GTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTKAK AKASFLSPSSPGGQPGRGAYAHFSGEGTEAVFQGCW---D >NP_001084019.1 midkine-B precursor [Xenopus laevis] ------------------------------------------------------------ -------------------------------MELRAFCVILLITILA--VSSQAAKNKKE KGKKG--------ASDC--TEWTWGSCIPNSKDCGAGTREGT-----CKEETRKLKCKIP CNWKKDFGADCKYKFENWGECNATTGQKVRSGTLKKALYNADCQQTVEAAKPCSLKTKSK SK----------------------GKKGKGKE-------- >XP_011474705.1 midkine [Oryzias latipes] ------------------------------------------------------------ ---------------------------------MRLLLSV--LLLLA--LALGAEANRRA KNHKGGKHDRSRPASECSLAETQFGKCVPEQGDCGEGLREAT-----CDGRTEKIHCKIP CNWKKDI-SDCKYKFGQWSSCDAATNTKTRSGTLKRVLFNAECQTTVKVSKPCSPKVK-K TR----------------------GEKSN----------- >KAB0376128.1 hypothetical protein FD755_012771 [Muntiacus reevesi] M----------------------------------------------------------- -----------------------QTPQYLQQRRKFAAAFLAFIFILA--VVDTAEAGKKE KPEKKVK------KSDC--GEWQWSVCVPTSGDCGLGTREGTRTGAECKQTMKTQRCKIP CNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRALHNADCQKTVTISKPCGKLTKSK PQ----------------------GSENKKKYPQKLRRID >KAB0342505.1 hypothetical protein FD754_019431 [Muntiacus muntjak] M----------------------------------------------------------- -----------------------QTPQYLQQRQKFAAAFLAFIFILA--VVDTAEAGKKE KPEKKVK------KSDC--GEWQWSVCVPTSGDCGLGTREGTRTGAECKQTMKTQRCKIP CNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRALHNADCQKTVTISKPCGKLTKSK PQ----------------------GTENKKKCPQKLRRID >XP_015820563.1 PREDICTED: midkine isoform X1 [Nothobranchius furzeri] ------------------------------------------------------------ --------------------------------MMGRLIAITLVLFLV--LT--ADASKRT KHHKAGKHEKSQ-NSECPAAETRFGKCVPDHGDCGDGLRETI-----CRDQVEKIHCRIP CNWKKDI-SDCKYRFGPWGPCDTATNTKTRSGTLKRALFNAECQTTIKVSKPCSHKTK-K TR----------------------GEKSSN---------- >XP_030282376.1 midkine [Sparus aurata] ------------------------------------------------------------ ---------------------------------MRSLLSVTLLLLLA--VTLAAEASRKA KNHKGGKHDKTRPASDCPPADTQYGKCVPEHGDCGDGLRDAT-----CKDHTDKIHCKIP CNWKKDI-SDCKYKFGPWGSCDAASNTKSRSGTLKRALFNADCQATVKVSKPCSPKVK-K AK----------------------GDKKSN----------
BMGE Cleaned alignment of selected proteins >sp|P21741|MK_HUMAN Midkine OS=Homo sapiens OX=9606 GN=MDK PE=1 SV=1 MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD >sp|P21741-2|MK_HUMAN Isoform 2 of Midkine OS=Homo sapiens OX=9606 GN=MDK MQHRGFLLLTLLALLALTSAVAKKK----------------------------------------------------ADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD >tr|Q9W767|Q9W767_DANRE Midkine a OS=Danio rerio OX=7955 GN=mdka PE=1 SV=1 RGLFSTLLVVLVALMIVTSEAGKKKEKNKGGKGAEWLYGSCVANNGDCGQGMREGTCNEQTRKVKCRVPCNWKKEFGADCKYKFGNWGECDAATSTKSRTGTLQKALFNVECQQTVSVTKPCTTKVKNKPKGKKGKGKG >tr|Q9DDG2|Q9DDG2_DANRE Midkine b OS=Danio rerio OX=7955 GN=mdkb PE=1 SV=1 --MRSLFSIALVLVVVITVEASMKKEKGKEPKASEWQYGKCVPNSGDCGNGIREATCNEQTKKTKCKVPCNWKKDFGADCKYKFGRWAECDTTTGTRSRSGTLKKALFNAECQTTIKVSKPCTPKTP-KPKKKKGKGKE >NP_001012336.1 midkine isoform a precursor [Mus musculus] MQHRGFFLLALLALLVVTSAVAKKKEKVKK---SEWTWGPCTPSSKDCGMGFREGTCGAQTQRVHCKVPCNWKKEFGADCKYKFESWGACDGSTGTKARQGTLKKARYNAQCQETIRVTKPCTSKTKSKTKAKKGKGKD >XP_006234653.1 midkine isoform X1 [Rattus norvegicus] MQHRSFFLLALVALLAVTTAVAKKKDKVKK---SEWTWGPCTPSSKDCGMGFREGTCGAQTQRIHCKVPCNWKKEFGADCKYKFESWGACDGSTGTKARQGTLKKARYNAQCQETIRVTKPCTSKTKSKAKAKKGKGKD >XP_005216459.1 midkine isoform X1 [Bos taurus] MQRRSFLLLALLALLALTSAVAKKKDKMKKGGPAEWTWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFETWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTKAKAKAKKGKEKD >NP_001106760.1 midkine precursor [Gallus gallus] MQPRGLLLLLALLLLAAAAEAAKKKEKMKKE--QDWHWGPCIPNSKDCGLGYREGSCGDESRKLKCKIPCNWKKKFGADCKYKFERWGGGSAKTGVKTRSGILKKALYNAECEEVVYVSKPCTAKMKAKAKAKKGKGKD >XP_016776261.1 midkine [Pan troglodytes] MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD >NP_001075636.1 midkine precursor [Oryctolagus cuniculus] MQHRGVLLLTLLALLALTSAVAKKKDKV-KGGPAEWTWGPCTPSSKDCGVGFREGTCGAQTQRIRCRLPCNWKKEFGADCKYKFDSWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKAKD >XP_005660995.1 midkine isoform X1 [Sus scrofa] MQRRGFLLLALFALLALTDAVAKKKDKVKKGGPAEWTWGPCTPSSKDCGVGFREGTCGAQTQRVRCRVPCNWKKEFGADCKYKFESWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD >XP_003206471.1 midkine [Meleagris gallopavo] MQPRALLLLLALLLLAATAEAVKKKEKAKKE--QDWRWGPCVPNSKDCGLGYREGTCGDESRKLKCKIPCNWKKKFGADCKYKFESWGGCSAQTGVKTRSGILKKALYNAQCEEVVYVSKPCAAKMKAKAKAKKGKGKD >XP_003815262.2 midkine [Pan paniscus] MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTSTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD >XP_023095580.1 midkine [Felis catus] MQHRGFLLLALFTLLALTTAVAKKKDKVKKGGPAEWTWGPCTPSSKDCGVGFREGTCGAQTQRVRCRVPCNWKKEFGADCKYKFESWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD >XP_004016486.3 midkine isoform X1 [Ovis aries] MQRRSFLLLALLALLALTSAVAKKKDKVKKGGLAEWTWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFETWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTKAKAKAKKGKEKD >XP_004051063.1 midkine [Gorilla gorilla gorilla] MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD >XP_005502241.1 midkine [Columba livia] MQVQGLLLLLALILLAATAEAGKKKEKVKKD--EDWRWGPCVPNSKDCGLGYREGTCKDESKKLKCKIPCNWKKKFGADCKYKFESWGGCSAQTGVKTRSGVLKKALYNAQCEEIVYVTKPCSSKIKSKSKAKKGKGKD >XP_006026987.1 midkine isoform X1 [Alligator sinensis] MQVRGLLLLMVLIIIAATSEAGKKKDKVKKN--EEWHWGSCVPNSRDCGLGYREGTCKEETKRVKCKIPCNWKKEFGADCKYKFENWTGCNVQTGFKTRSGTLKKALYNAQCQDTILVTKPCSPKIKSKSKVRKGKGKE >XP_014457641.1 PREDICTED: midkine [Alligator mississippiensis] MQVRGLLLLMVLIIIAATSEAGKKKDKVKKN--EEWHWGSCVPNSKDCGLGYREGTCKEETKRVKCKIPCNWKKEFGADCKYKFENWTGCNVQTGFKTRSGTLKKALYNAQCQDTILVTKPCSPKIKSKSKARKGKGKE >XP_024110593.1 midkine isoform X1 [Pongo abelii] MQHRGFLLLTFLALLALTSAVAKKKDKVKKGGPAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD >XP_017914647.1 PREDICTED: midkine isoform X1 [Capra hircus] MQRRSFLLLALLALLALTSAVAKKKDKVKKGGLAEWTWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFETWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTKAKAKAKKGKEKD >XP_020737487.1 midkine isoform X1 [Odocoileus virginianus texanus] MQRRSFLLLAFLALLALTSAVAKKKDKVKKGGPAEWTWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFETWGACD-GTGTRARQGTLKKARHNAQCQGTVRVTKPCSPKAKAKAKAKKGKEKD >XP_038280452.1 midkine isoform X1 [Canis lupus familiaris] MQLRGFLLLALLTLLALPAAVAKKKDKVKKGGPAEWTWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGSGTKARQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD >XP_040184121.1 midkine [Rana temporaria] MELRALCVIVLVAILAVSSQAAKKKDKGKKG--SEWKWSPCVPNSKDCGVGTREGTCKEETSKLKCKIPCNWKKPFGADCKYKFNNWGECNTETNVKSRTGTLKKALYNAECQQTVEATKPCSVKVKTKSKGKKGKGKD >XP_043337057.1 midkine isoform X1 [Cervus canadensis] MQRRSFLLLALLALLALTSAVAKKKDKVKKGGPAEWTWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFETWGACD-GTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTKAKAKAKKGKEKD >XP_043337059.1 midkine isoform X3 [Cervus canadensis] MQRRSFLLLALLALLALTSAVAKKKDKVKKGGPAEWTWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFETWGACD-GTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTKAKAKAKKGKEKD >KAF4009423.1 hypothetical protein G4228_000599 [Cervus hanglu yarkandensis] MQRRSFLLLALLALLALTSAVAKKKDKVKKGGPAEWTWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFETWGACD-GTGTKARQGTLKKARYNAQCQETIRVTKPCSPKTKAKAKGEGTEAVF >NP_001084019.1 midkine-B precursor [Xenopus laevis] MELRAFCVILLITILAVSSQAAKKKEKGKKG--TEWTWGSCIPNSKDCGAGTREGTCKEETRKLKCKIPCNWKKDFGADCKYKFENWGECNATTGQKVRSGTLKKALYNADCQQTVEAAKPCSLKTKSKSKGKKGKGKE >XP_011474705.1 midkine [Oryzias latipes] --MRLLLSV--LLLLALALGAEARRAKNHKGGKAETQFGKCVPEQGDCGEGLREATCDGRTEKIHCKIPCNWKKDI-SDCKYKFGQWSSCDAATNTKTRSGTLKRVLFNAECQTTVKVSKPCSPKVK-KTRGEKSN--- >KAB0376128.1 hypothetical protein FD755_012771 [Muntiacus reevesi] RRKFAAAFLAFIFILAVVDTAEAKKEKPEKKVKGEWQWSVCVPTSGDCGLGTREGTCKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRALHNADCQKTVTISKPCGKLTKSKPQGSENKKKY >KAB0342505.1 hypothetical protein FD754_019431 [Muntiacus muntjak] RQKFAAAFLAFIFILAVVDTAEAKKEKPEKKVKGEWQWSVCVPTSGDCGLGTREGTCKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRALHNADCQKTVTISKPCGKLTKSKPQGTENKKKC >XP_015820563.1 PREDICTED: midkine isoform X1 [Nothobranchius furzeri] -MMGRLIAITLVLFLVLT--ADAKRTKHHKAGKAETRFGKCVPDHGDCGDGLRETICRDQVEKIHCRIPCNWKKDI-SDCKYRFGPWGPCDTATNTKTRSGTLKRALFNAECQTTIKVSKPCSHKTK-KTRGEKSSN-- >XP_030282376.1 midkine [Sparus aurata] --MRSLLSVTLLLLLAVTLAAEARKAKNHKGGKADTQYGKCVPEHGDCGDGLRDATCKDHTDKIHCKIPCNWKKDI-SDCKYKFGPWGSCDAASNTKSRSGTLKRALFNADCQATVKVSKPCSPKVK-KAKGDKKSN--
PhyML tree of selected proteins (XP_030282376_1_midkine__Sparus_aurata_:0.0855388,(XP_015820563_1_PREDICTED__midkine_isoform_X1__Nothobranchius_furzeri_:0.24650039,XP_011474705_1_midkine__Oryzias_latipes_:0.10950721):0.05311684,(tr_Q9DDG2_Q9DDG2_DANRE_Midkine_b_OS_Danio_rerio_OX_7955_GN_mdkb_PE_1_SV_1:0.2040612,(tr_Q9W767_Q9W767_DANRE_Midkine_a_OS_Danio_rerio_OX_7955_GN_mdka_PE_1_SV_1:0.29311977,(((((XP_014457641_1_PREDICTED__midkine__Alligator_mississippiensis_:0.00000001,XP_006026987_1_midkine_isoform_X1__Alligator_sinensis_:0.01457247):0.1086003,(XP_005502241_1_midkine__Columba_livia_:0.00540836,(XP_003206471_1_midkine__Meleagris_gallopavo_:0.02002077,NP_001106760_1_midkine_precursor__Gallus_gallus_:0.08577504):0.13923352):0.1688837):0.13869974,(((XP_038280452_1_midkine_isoform_X1__Canis_lupus_familiaris_:0.04807987,(NP_001075636_1_midkine_precursor__Oryctolagus_cuniculus_:0.03185293,(XP_024110593_1_midkine_isoform_X1__Pongo_abelii_:0.00763031,(XP_003815262_2_midkine__Pan_paniscus_:0.00760595,(sp_P21741_2_MK_HUMAN_Isoform_2_of_Midkine_OS_Homo_sapiens_OX_9606_GN_MDK:0.00000001,(XP_016776261_1_midkine__Pan_troglodytes_:0.00000001,(sp_P21741_MK_HUMAN_Midkine_OS_Homo_sapiens_OX_9606_GN_MDK_PE_1_SV_1:0.00000001,XP_004051063_1_midkine__Gorilla_gorilla_gorilla_:0.00000001):0.00000001):0.00000001):0.00000001):0.00000001):0.02316813):0.00764782):0.00000001,((XP_005660995_1_midkine_isoform_X1__Sus_scrofa_:0.01546147,XP_023095580_1_midkine__Felis_catus_:0.01314271):0.01839538,(KAF4009423_1_hypothetical_protein_G4228_000599__Cervus_hanglu_yarkandensis_:0.06935466,((XP_043337057_1_midkine_isoform_X1__Cervus_canadensis_:0.00000001,XP_043337059_1_midkine_isoform_X3__Cervus_canadensis_:0.00000001):0.00000001,(XP_005216459_1_midkine_isoform_X1__Bos_taurus_:0.00762816,((XP_004016486_3_midkine_isoform_X1__Ovis_aries_:0.00000001,XP_017914647_1_PREDICTED__midkine_isoform_X1__Capra_hircus_:0.00000001):0.0075116,XP_020737487_1_midkine_isoform_X1__Odocoileus_virginianus_texanus_:0.04702946):0.00000001):0.00000001):0.00000001):0.03918763):0.00000001):0.04940438,(XP_006234653_1_midkine_isoform_X1__Rattus_norvegicus_:0.02321601,NP_001012336_1_midkine_isoform_a_precursor__Mus_musculus_:0.02981939):0.02655497):0.28599719):0.1298764,(XP_040184121_1_midkine__Rana_temporaria_:0.12235356,NP_001084019_1_midkine_B_precursor__Xenopus_laevis_:0.12769169):0.13420867):0.07420802,(KAB0342505_1_hypothetical_protein_FD754_019431__Muntiacus_muntjak_:0.00000001,KAB0376128_1_hypothetical_protein_FD755_012771__Muntiacus_reevesi_:0.02142177):0.88175386):0.11274068):0.12042206):0.44801565);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)