Click here to access PB0218 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0218 P21741 Midkine MDK ARAP, MK, NEGF2 Homo_sapiens In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity).

DomainsGene Ontology
PF01091 (PTN_MK_C)
PF05196 (PTN_MK_N)
GO:0062023 (colocalizes with) collagen-containing extracellular matrix
GO:0005515 (enables) protein binding
GO:0008083 (enables) growth factor activity
GO:0008201 (enables) heparin binding
GO:0035374 (enables) chondroitin sulfate binding
GO:1904399 (enables) heparan sulfate binding
GO:0001662 (involved in) behavioral fear response
GO:0002232 (involved in) leukocyte chemotaxis involved in inflammatory response
GO:0002286 (involved in) T cell activation involved in immune response
GO:0002690 (involved in) positive regulation of leukocyte chemotaxis
GO:0007010 (involved in) cytoskeleton organization
GO:0007162 (involved in) negative regulation of cell adhesion
GO:0007165 (involved in) signal transduction
GO:0007399 (involved in) nervous system development
GO:0007614 (involved in) short-term memory
GO:0009410 (involved in) response to xenobiotic stimulus
GO:0009611 (involved in) response to wounding
GO:0009725 (involved in) response to hormone
GO:0010667 (involved in) negative regulation of cardiac muscle cell apoptotic process
GO:0010718 (involved in) positive regulation of epithelial to mesenchymal transition
GO:0010759 (involved in) positive regulation of macrophage chemotaxis
GO:0010838 (involved in) positive regulation of keratinocyte proliferation
GO:0010976 (involved in) positive regulation of neuron projection development
GO:0010996 (involved in) response to auditory stimulus
GO:0016477 (involved in) cell migration
GO:0021542 (involved in) dentate gyrus development
GO:0021681 (involved in) cerebellar granular layer development
GO:0021766 (involved in) hippocampus development
GO:0021987 (involved in) cerebral cortex development
GO:0030154 (involved in) cell differentiation
GO:0030279 (involved in) negative regulation of ossification
GO:0030325 (involved in) adrenal gland development
GO:0030335 (involved in) positive regulation of cell migration
GO:0030421 (involved in) defecation
GO:0032330 (involved in) regulation of chondrocyte differentiation
GO:0032735 (involved in) positive regulation of interleukin-12 production
GO:0042246 (involved in) tissue regeneration
GO:0043524 (involved in) negative regulation of neuron apoptotic process
GO:0044849 (involved in) estrous cycle
GO:0045582 (involved in) positive regulation of T cell differentiation
GO:0045590 (involved in) negative regulation of regulatory T cell differentiation
GO:0045785 (involved in) positive regulation of cell adhesion
GO:0045893 (involved in) positive regulation of DNA-templated transcription
GO:0046850 (involved in) regulation of bone remodeling
GO:0048477 (involved in) oogenesis
GO:0048714 (involved in) positive regulation of oligodendrocyte differentiation
GO:0050729 (involved in) positive regulation of inflammatory response
GO:0050795 (involved in) regulation of behavior
GO:0050896 (involved in) response to stimulus
GO:0051384 (involved in) response to glucocorticoid
GO:0051781 (involved in) positive regulation of cell division
GO:0061036 (involved in) positive regulation of cartilage development
GO:0071673 (involved in) positive regulation of smooth muscle cell chemotaxis
GO:0090023 (involved in) positive regulation of neutrophil chemotaxis
GO:0090090 (involved in) negative regulation of canonical Wnt signaling pathway
GO:0106015 (involved in) negative regulation of inflammatory response to wounding
GO:0106016 (involved in) positive regulation of inflammatory response to wounding
GO:0106091 (involved in) glial cell projection elongation
GO:1900026 (involved in) positive regulation of substrate adhesion-dependent cell spreading
GO:1901215 (involved in) negative regulation of neuron death
GO:1903039 (involved in) positive regulation of leukocyte cell-cell adhesion
GO:1904036 (involved in) negative regulation of epithelial cell apoptotic process
GO:1904996 (involved in) positive regulation of leukocyte adhesion to vascular endothelial cell
GO:1905555 (involved in) positive regulation of blood vessel branching
GO:1905564 (involved in) positive regulation of vascular endothelial cell proliferation
GO:1905653 (involved in) positive regulation of artery morphogenesis
GO:2000179 (involved in) positive regulation of neural precursor cell proliferation
GO:2000249 (involved in) regulation of actin cytoskeleton reorganization
GO:2000347 (involved in) positive regulation of hepatocyte proliferation
GO:2000391 (involved in) positive regulation of neutrophil extravasation
GO:2001224 (involved in) positive regulation of neuron migration
GO:0005576 (located in) extracellular region
GO:0005737 (located in) cytoplasm
GO:0042995 (located in) cell projection

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)