PB0216

DATABASE

Click here to access PB0216 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0216	Q9Y287	Integral membrane protein 2B	ITM2B	ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, RDGCA, imBRI2	Homo_sapiens	Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.

Domains

Gene Ontology

PF04089 (BRICHOS)

GO:0001540 (enables) amyloid-beta binding
GO:0005515 (enables) protein binding
GO:0005524 (enables) ATP binding
GO:0007399 (involved in) nervous system development
GO:0042985 (involved in) negative regulation of amyloid precursor protein biosynthetic process
GO:0000139 (located in) Golgi membrane
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005768 (located in) endosome
GO:0005794 (located in) Golgi apparatus
GO:0005886 (located in) plasma membrane
GO:0010008 (located in) endosome membrane
GO:0016020 (located in) membrane
GO:0016021 (located in) integral component of membrane
GO:0030660 (located in) Golgi-associated vesicle membrane
GO:0031301 (located in) integral component of organelle membrane
GO:0043231 (located in) intracellular membrane-bounded organelle
GO:0070062 (located in) extracellular exosome

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)
Selected proteins from model organisms

>sp|Q9Y287|ITM2B_HUMAN Integral membrane protein 2B OS=Homo sapiens OX=9606 GN=ITM2B PE=1 SV=1
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFG
LAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIK
IFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNL
LELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGI
QKREASNCFAIRHFENKFAVETLICS
>sp|Q9Y287-2|ITM2B_HUMAN Isoform 2 of Integral membrane protein 2B OS=Homo sapiens OX=9606 GN=ITM2B
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFG
LAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDK
ETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS
>tr|Q803H7|Q803H7_DANRE Integral membrane protein 2 OS=Danio rerio OX=7955 GN=itm2ba PE=2 SV=1
MVKLTFNSALGQKDLKKEEKDEALIPHDLDVEDVLRVRQQSRAWCWCMCLGLALILSGVV
VGGAYLYRYYFIEEERMYFCGVNYREENYKMQDSQEDTDMDLPAAYKRIEEKVRVLEDEG
VELINIPVPKFSDSDPADIVHDFNRRLTAYLDLRLNKCYVIPLNTSVVMPPKDFLELLVN
IKAGTYLPQSYLVREQMMVTGKVEHVDQLGYFIYGLCRGRDTYKLERRETVLGIQKREAL
NCHKILHFENKFVVETLICEQ
>NP_032436.1 integral membrane protein 2B precursor [Mus musculus]
MVKVTFNSALAQKEAKKDEPKSSEEALIVPPDAVAVDCKDPGDVVPVGQRRAWCWCMCFGLAFMLAGVIL
GGAYLYKYFALQPDDVYYCGLKYIKDDVILNEPSADAPAARYQTIEENIKIFEEDAVEFISVPVPEFADS
DPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHMVITDRIE
NVDNLGFFIYRLCHDKETYKLQRRETIRGIQKREASNCFTIRHFENKFAVETLICS

>NP_001006964.1 integral membrane protein 2B [Rattus norvegicus]
MVKVTFNSALAQKEAKKDEPKSSEEALIAPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFGLAFMLAGVIL
GGAYLYKYFALQPDDVYYCGLKYIKDDVILSEPSADAPAARYQTIEENIKIFEEDAVEFISVPVPEFADS
DPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIE
NVDHLGFFIYRLCHDKETYKLQRRETIRGIQKREASNCFTIRHFENKFAVETLICS

>NP_990416.2 integral membrane protein 2B [Gallus gallus]
MVKVSFNSALAQKEAAKKEEENSQVLILPPDAKEPEDVVVPAGQRRAWCWCMCFGLAFMLAGVILGGAYL
YKYFAFQQGGVYFCGIKYIEDGLSLPESGAEAQSARYHTIEQNIQILEEEDVEFISVPVPEFADSDPADI
VHDFHRRLTAYLDLSLDKCYVIPLNTSVVMPPKNFLELLINIKAGTYLPQSYLIHEQMIVTDRIENVDQL
GFFIYRLCRGKETYKLQRKEAMKGIQKREAVNCRKIRHFENRFAMETLICEQ

>NP_001092017.1 integral membrane protein 2B [Pan troglodytes]
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFGLAFMLAGVIL
GGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADS
DPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIE
NIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS

>XP_038286861.1 integral membrane protein 2B [Canis lupus familiaris]
MVKVTFNSALAQKEAKKDEPKCGEEALIIPPDAVAVDCKDPDEVVPVGQRRAWCWCMCFGLAFMLAGVIL
GGAYLYKYFALQPDDVYYCGIKYIKDDVLLNEPSADAPAARYQTIEENIKIFEEDEVEFISVPVPEFADS
DPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIE
NIDHLGFFIYRLCHDKETYKLQRRETIRGIQKREVSNCVTIRHFENKFAVETVICP

>NP_001030265.1 integral membrane protein 2B [Bos taurus]
MVKVTFNSALAQKEAKKDESKSGEEALIIPPDAVAVDCKDPDEVVPVGQRRAWCWCMCFGLAFMLAGVIL
GGAYLYKYFAFQPDDVYYCGIKYIKDDVILNEPSADAPASRYQTIEENIKIFEEDEVEFISVPVPEFADS
DPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHMVITDRIE
NIDHLGFYIYRLCHDKETYKLQRRETIKGIQKRSADVCVTIRHFENRFAVETLICP

>XP_005652396.2 integral membrane protein 2B isoform X1 [Sus scrofa]
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDTVAVDCKDPDEVVPVGQRRAWCWCMCFGLAFMLAGVIL
GGAYLYKYFALQVSGKMPDDVYYCGIKYIKDDVILNEPPANAPAARYQTIEENIKIFEEDGVEFISVPVP
EFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVI
TDRIENIDHLGFYIYRLCHDKETYKLQRKETVKGIQKREASNCATIRHFENKFAVETLICS

>NP_001127776.1 integral membrane protein 2B [Ovis aries]
MVKVTFNSALAQKEAKKDESKSGEEALIIPPDAVAVDCKDPDEVVPVGQRRAWCWCMCFGLAFMLAGVIL
GGAYLYKYFAFQPDDVYYCGIKYIKDDVILNEPSADAPASRYQTIEENIKIFEEDEVEFISVPVPEFADS
DPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHMVITDRIE
NIDHLGFYIYRLCHDKETYKLQRRDTIKGIQKRAASTCVTIRHFENKFAVETLICS

>XP_002720768.1 PREDICTED: integral membrane protein 2B [Oryctolagus cuniculus]
MVKVTFNSALAQKEAKKDDPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFGLAFMLAGVIL
GGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAARYQTIEENIKIFEEDEVEFISVPVPEFADS
DPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLLHEHMVITDRIE
NIDHLGFFIYRLCHDKETYKLQRRDTIKGIQKREVSDCVTIRHFENKFAVETLICS

>XP_002824307.1 integral membrane protein 2B [Pongo abelii]
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFGLAFMLAGVIL
GGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADS
DPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIE
NIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS

>XP_010727120.1 integral membrane protein 2B [Meleagris gallopavo]
MCFGLAFMLAGVILGGAYLYKYFAFQQGGVYFCGIKYIEDGLSLPESGAEAQSARYHTIEQNIQILEEED
VEFISVPVPEFADSDPADIVHDFHRRLTAYLDLSLDKCYVIPLNTSVVMPPKNFLELLINIKAGTYLPQS
YLIHEQMIVTDRIENVDQLGFFIYRLCRGKETYKLQRKEAMKGIQKREAVNCRKIRHFENRFAMETLICE
Q

>XP_034792608.1 integral membrane protein 2B [Pan paniscus]
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFGLAFMLAGVIL
GGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADS
DPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIE
NIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS

>XP_011278441.1 integral membrane protein 2B [Felis catus]
MVKVTFNSALAQKEAKKDDPKCGEEALIIPPDAVAVDCKDPDEVVPVGQRRAWCWCMCFGLAFMLAGVIL
GGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAARYQTIEENIKIFEEDEVEFISVPVPEFADS
DPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIE
NVDHLGFFIYRLCHDKETYKLQRRETIKGIQKREVSNCVTIRHFENKFAVETVICP

>XP_004054544.1 integral membrane protein 2B [Gorilla gorilla gorilla]
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFGLAFMLAGVIL
GGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADS
DPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIE
NIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS

>XP_005501874.1 integral membrane protein 2B isoform X1 [Columba livia]
MVKVSFNSALAQKEAAKKEEENSQVLILPPDAKDPEDAVPVGQRRAWCWCMYFGLAFMLAGVILGGAYLY
KYFAFQQNGVYFCGIKYIEDGLSLPEPGAEAQSARYHTIEQNIQILEEEDVEFISVPVPEFADSDPADIV
HDFHRRLTAYLDLSLDKCYVIPLNTSVVMPPKNFLELLINIKAGTYLPQSYLIHEQMIVTDRIENVDQLG
FFIYRLCRGKETYKLQRKEAMKGIQKREAVNCRKIRHFENRFAMETLICEQ

>XP_017912239.1 PREDICTED: integral membrane protein 2B [Capra hircus]
MVKVTFNSALAQKEAKKDESKSGEEALIIPPDAVAVDCKDPDEVVPVGQRRAWCWCMCFGLAFMLAGVIL
GGAYLYKYFAFQPDDVYYCGIKYIKDDVILNEPSADAPASRYQTIEENIKIFEEDEVEFISVPVPEFADS
DPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHMVITDRIE
NIDHLGFYIYRLCHDKETYKLQRRETIKGIQKRAASACVTIRHFENKFAVETLICS

>XP_014378463.1 integral membrane protein 2B [Alligator sinensis]
MGSLCVWHMVNQDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFAFQQGGVYFCGLQYIEDG
LTLTEPDPEAPAARYHTIEENIQILEEEDVEFISVPVPEFADSDPADIVHDFHRRLTAYLDLSLDKCYVI
PLNTSVVMPPKNFLELLINIKAGTYLPQSYLIHEQMIVTDRIENVDQLGFFIYRLCRGKETYKLQRKEIM
KGIQKREASNCRKIRHFENRFAMETLICEQ

>XP_006261837.1 PREDICTED: integral membrane protein 2B [Alligator mississippiensis]
MVKVSFSSALAQKEAAKKEEENSQVLILPTAAKDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLY
KYFAFQQGGVYFCGLQYIEDGLTLTEPDPEAPAARYHTIEENIQILEEEDVEFISVPVPEFADSDPADIV
HDFHRRLTAYLDLSLDKCYVIPLNTSVVMPPKNFLELLINIKAGTYLPQSYLIHEQMIVTDRIENVDQLG
FFIYRLCRGKETYKLQRKEIMKGIQKREASNCRKIRHFENRFAMETLICEQ

>XP_015821286.1 PREDICTED: integral membrane protein 2B [Nothobranchius furzeri]
MVKVSFNAALAQKDVKKDFETLIPAENRDTEAALVVRQRSRAWCWCVCLGIALFLSGVVVAGAYLYRYYV
VEGHRNLISSSHWADPQQQDNEVFICGVNYHENDYMITEEEEMMEEQSFRQRLLQERIQVLVPDQVEIIH
VPVPDFEDGDPADIVHDFQRRLTAYLDLSLDKCYVIPLNTSVVMPPTDLLDLLINVKAGTYLPQSYLVHE
EMVVTERLENIENLGAFIYTLCRGKDTYKLQRRDRILGMQKREALTCHKIRHFENTFVVETLICEP

>XP_020732181.1 integral membrane protein 2B [Odocoileus virginianus texanus]
MVKVTFNSALAQKEAKKDEAKSGEEALIIPPDAVAVDCKDPDEVVPVGQRRAWCWCMCFGLAFMLAGVIL
GGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAARYQTIEENIKIFEEDEVEFISVPVPEFADS
DPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHMVITDRIE
NIDHLGFYIYRLCHDKETYKLQRRETIKGIQKREASICATIRHFENRFAVETLICS

>XP_040197170.1 integral membrane protein 2B [Rana temporaria]
MVKLAFNSSLAQKDAKKDDENSEVLIITDNKEVEEVVPLGQRRAWCWCMCFGLAFMLAGIVLGGAYLYRY
FVSQRGVYFCGIRYTDDDMTLAEPYADSSRIRYHSFKERIQILEDEEVELINVPVPEFADSDPADIVHDF
HRKLTAYLDLSLNKCYVIPLNTSIVMPPKNFLELLINIKAGTYLPQSYLIHEQMVVTDRIENVDQLGVFI
RRLCQDKETYKLQRREPVRGRQKRDLQGCFRINHFENKFAVQTMICH
>XP_043334233.1 integral membrane protein 2B [Cervus canadensis]
MVKVTFNSALAQKEAKKDEAKSGEEALIIPPDAVAVDCKDPDEVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFA
LQPDDVYYCGIKYIKDDVILNEPSADAPAARYQTIEENIKIFEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLN
LDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFYIYRLCHDKETYKLQRRETIKGI
QKREASVCATIRHFENRFAVETLICS

>KAF4025594.1 hypothetical protein G4228_017608 [Cervus hanglu yarkandensis]
MVKVTFNSALAQKEAKKDEAKSGEEALIIPPDAVAVDCKPDDVYYCGIKYIKDDVILNEPSADAPAARYQTIEENIKIFE
EDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHM
VITDRIENIDHLGFYIYRLCHDKETYKLQRRETIKGIQKREASVCATIRHFENRFAVETLICS
>NP_001080382.1 integral membrane protein 2B L homeolog [Xenopus laevis]
MVKLTFNSTLGQKDGKKEDENNEVLIIPEAKEPEDVVPLGQRRAWCWCMCFGLAFMLAGIVLGSAYLYKYFAMQRGVYFC
GIRYLEDDAALTEPYAETPVRYHSFRESIQILEEEEVELINVPVPEFADSDPVDIVHDFHRKLTAYLDLNLNKCYVIPLN
TSIVMPPKNFLELLLNIKAGTYLPQSYLVHEQMIVTDRIENVDQLGFFIYRLCRDKDTYKLQRKETIRGFHKREAENCHT
IRHFANKFPVETQICEH
>XP_023806972.1 integral membrane protein 2B isoform X2 [Oryzias latipes]
MVKVSFNSALAQKEVKKDDESLIPEEEVEVDVETAVLVRRQSRAWCWCVCLGVALMLSGVLIAGAYLFRYYTGPGEPVFF
CGVNYIEDDYMIRDEEVDVPSSLRELEMTIRILEEEQVEIISVPVPNFEDGDPADIVHDFDRRMTAYLDLSLDKCYVIPL
NTSAVMPPRDLLDLLINVKAGTYLPQSYLVHEEMVVTERLERVDQLGYFIYNLCRNKETYKLQRRDRILGMQKREVQNCR
KIRHFENNFVVETQICEL
>XP_030283386.1 integral membrane protein 2B isoform X2 [Sparus aurata]
MVKVSFNSALGQKDVKKDAETLLTEEDKDAEAALPVRQQSRAWCWCMCLGLALMLSGVVVGGAYLYRYYILEEGHVFVCG
VNYREEDFMIREEEEVEVELPNQFPLRQLEERIRVLEDEQVELINVPVPEFDDGDPADIVHDFQRKLTAYLDLSLNKCYV
IPLNTSIVMPPRDFLELLVNVKAGTYLPQSYLIHEEMIVTERLEHVDQLGYFIYNLCRGKDTYKLQRRDRILGMQKREAL
NCHKIRHFGSRVVVETLICEP
>CAE1261877.1 ITM2B [Sepia pharaonis]
MTIYKFQQVGKKSKEDEQPETVKEPLTAEKEKDPEASKLPKAIHVTFIPRRSKTCINMSLMFISLIVLSGGAIGGIYLYG
HLKHTVIRGRCGVIYTQDLFMQKDPPVPIASGFRYNDQNPSKNDMSVSFFEETIEITDDYYERVEIPKFDECENAIVLHD
FERNFTAIVDKDIGRCFIMKLNRSVIAPPKDLWDLLHKLKSGYYMPRATVVRETYSVEIPALDNLSILGPYVRSECSRFT
TFMLRKIINQRLKRSAESLSNSEHYGFADHKQRLWKLKVFFP
>XP_026301546.1 integral membrane protein 2C [Apis mellifera]
MTFITKAITEKKADKKEQSLFVQKNPAENGKRDAEAQCLKSDVGGHYFVSKRSIYRIHVTATFLLFLVALMILIIGVIGG
LYIYRQYARTQMHKFKTGWYSIPYDKSNKPPYAKDAVHQGLIADSDLILKSLTRATEREAMDIEKNVDSDIRSFFKERFE
IDLENEHYEKIDVPDFRGGRQGRFIHDFSINKTGIIDIDGESCFVMPLNRQTVLPPRNMYDLLRKMYNGYYEVNTQIVRE
TMKVITPPITDLSVVGTYIARECQDFPTYMLTKVTSNVVKRSISSGVFGQFAGKNIIEFDILNLDDVSEYNKKSSQN
>XP_038051184.1 integral membrane protein 2B-like [Patiria miniata]
MKIYAADGKVQQAKVVYNGDTYTTVAVPTKAGQYECKCKDEDLKLTKSSHPKVTPNHHQTRCWSCGLSACLIFSIVASVG
LFVLLYSAARPVSIEDSFSVGECELPILPDERQPYGYKQHMAADKETMTETFDIPEINANHPATIMHDFYNEVTVYLDRL
EGICFVMKLNTTQVVPPRYLLEAFIRYKRGDFALDIDTIQETMEVQTPPIADISSLGLGTELLCHELPTYWLVKPGTPVL
RKRSIPSDGHHVTYFNGLHMIDLTVTNGGV

Mafft alignment of selected proteins

>sp|Q9Y287|ITM2B_HUMAN Integral membrane protein 2B OS=Homo sapiens OX=9606 GN=ITM2B PE=1 SV=1
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVA---VDCKDPDD---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFALQ-----------------PDD
VYYCGIKYIKDDVILNEPS--------------ADAPAA-LY-----------------Q
TIEENIKI-FEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPRNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENIDHLGFFIYRLCHDKETYKL
QRRETIKGIQKREASNCFAIRHFE----NKFAVETLICS--------------
>sp|Q9Y287-2|ITM2B_HUMAN Isoform 2 of Integral membrane protein 2B OS=Homo sapiens OX=9606 GN=ITM2B
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVA---VDCKDPDD---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFALQ--------------------
------------------------------------------------------------
------------------------------------------------------------
----------------AGTYLPQSYLIHEHM-VITDRIENIDHLGFFIYRLCHDKETYKL
QRRETIKGIQKREASNCFAIRHFE----NKFAVETLICS--------------
>tr|Q803H7|Q803H7_DANRE Integral membrane protein 2 OS=Danio rerio OX=7955 GN=itm2ba PE=2 SV=1
MVKLTFNSALGQKDLKKEEK---DEALIP----------HDLDVED---------VLRVR
QQSRAWC-----WCMCLGLALILSGVVVGGAYLYRYYFIE-----------------EER
MYFCGVNYREENYKMQDSQE----------DTDMDLPAA--Y-----------------K
RIEEKVRV-LEDEGVELINIPVPKFSDSDPADIVHDFNRRLTAYLDLRLNKCYVIPLNTS
VVMPPKDFLELLVNIKAGTYLPQSYLVREQM-MVTGKVEHVDQLGYFIYGLCRGRDTYKL
ERRETVLGIQKREALNCHKILHFE----NKFVVETLICE-------------Q
>NP_032436.1 integral membrane protein 2B precursor [Mus musculus]
MVKVTFNSALAQKEAKKDEPKSSEEALIVPPDAVA---VDCKDPGD---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFALQ-----------------PDD
VYYCGLKYIKDDVILNEPS--------------ADAPAA-RY-----------------Q
TIEENIKI-FEEDAVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPKNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENVDNLGFFIYRLCHDKETYKL
QRRETIRGIQKREASNCFTIRHFE----NKFAVETLICS--------------
>NP_001006964.1 integral membrane protein 2B [Rattus norvegicus]
MVKVTFNSALAQKEAKKDEPKSSEEALIAPPDAVA---VDCKDPDD---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFALQ-----------------PDD
VYYCGLKYIKDDVILSEPS--------------ADAPAA-RY-----------------Q
TIEENIKI-FEEDAVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPRNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENVDHLGFFIYRLCHDKETYKL
QRRETIRGIQKREASNCFTIRHFE----NKFAVETLICS--------------
>NP_990416.2 integral membrane protein 2B [Gallus gallus]
MVKVSFNSALAQKEAAKKEEEN-SQVLILPP--------DAKEPED--------VVVPAG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFAFQ-----------------QGG
VYFCGIKYIEDGLSLPESG--------------AEAQSA-RY-----------------H
TIEQNIQI-LEEEDVEFISVPVPEFADSDPADIVHDFHRRLTAYLDLSLDKCYVIPLNTS
VVMPPKNFLELLINIKAGTYLPQSYLIHEQM-IVTDRIENVDQLGFFIYRLCRGKETYKL
QRKEAMKGIQKREAVNCRKIRHFE----NRFAMETLICE-------------Q
>NP_001092017.1 integral membrane protein 2B [Pan troglodytes]
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVA---VDCKDPDD---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFALQ-----------------PDD
VYYCGIKYIKDDVILNEPS--------------ADAPAA-LY-----------------Q
TIEENIKI-FEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPRNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENIDHLGFFIYRLCHDKETYKL
QRRETIKGIQKREASNCFAIRHFE----NKFAVETLICS--------------
>XP_038286861.1 integral membrane protein 2B [Canis lupus familiaris]
MVKVTFNSALAQKEAKKDEPKCGEEALIIPPDAVA---VDCKDPDE---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFALQ-----------------PDD
VYYCGIKYIKDDVLLNEPS--------------ADAPAA-RY-----------------Q
TIEENIKI-FEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPRNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENIDHLGFFIYRLCHDKETYKL
QRRETIRGIQKREVSNCVTIRHFE----NKFAVETVICP--------------
>NP_001030265.1 integral membrane protein 2B [Bos taurus]
MVKVTFNSALAQKEAKKDESKSGEEALIIPPDAVA---VDCKDPDE---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFAFQ-----------------PDD
VYYCGIKYIKDDVILNEPS--------------ADAPAS-RY-----------------Q
TIEENIKI-FEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPKNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENIDHLGFYIYRLCHDKETYKL
QRRETIKGIQKRSADVCVTIRHFE----NRFAVETLICP--------------
>XP_005652396.2 integral membrane protein 2B isoform X1 [Sus scrofa]
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDTVA---VDCKDPDE---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFALQVSGKM------------PDD
VYYCGIKYIKDDVILNEPP--------------ANAPAA-RY-----------------Q
TIEENIKI-FEEDGVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPRNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENIDHLGFYIYRLCHDKETYKL
QRKETVKGIQKREASNCATIRHFE----NKFAVETLICS--------------
>NP_001127776.1 integral membrane protein 2B [Ovis aries]
MVKVTFNSALAQKEAKKDESKSGEEALIIPPDAVA---VDCKDPDE---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFAFQ-----------------PDD
VYYCGIKYIKDDVILNEPS--------------ADAPAS-RY-----------------Q
TIEENIKI-FEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPKNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENIDHLGFYIYRLCHDKETYKL
QRRDTIKGIQKRAASTCVTIRHFE----NKFAVETLICS--------------
>XP_002720768.1 PREDICTED: integral membrane protein 2B [Oryctolagus cuniculus]
MVKVTFNSALAQKEAKKDDPKSGEEALIIPPDAVA---VDCKDPDD---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFALQ-----------------PDD
VYYCGIKYIKDDVILNEPS--------------ADAPAA-RY-----------------Q
TIEENIKI-FEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPRNLLELLINIKAGTYLPQSYLLHEHM-VITDRIENIDHLGFFIYRLCHDKETYKL
QRRDTIKGIQKREVSDCVTIRHFE----NKFAVETLICS--------------
>XP_002824307.1 integral membrane protein 2B [Pongo abelii]
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVA---VDCKDPDD---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFALQ-----------------PDD
VYYCGIKYIKDDVILNEPS--------------ADAPAA-LY-----------------Q
TIEENIKI-FEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPRNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENIDHLGFFIYRLCHDKETYKL
QRRETIKGIQKREASNCFAIRHFE----NKFAVETLICS--------------
>XP_010727120.1 integral membrane protein 2B [Meleagris gallopavo]
------------------------------------------------------------
--------------MCFGLAFMLAGVILGGAYLYKYFAFQ-----------------QGG
VYFCGIKYIEDGLSLPESG--------------AEAQSA-RY-----------------H
TIEQNIQI-LEEEDVEFISVPVPEFADSDPADIVHDFHRRLTAYLDLSLDKCYVIPLNTS
VVMPPKNFLELLINIKAGTYLPQSYLIHEQM-IVTDRIENVDQLGFFIYRLCRGKETYKL
QRKEAMKGIQKREAVNCRKIRHFE----NRFAMETLICE-------------Q
>XP_034792608.1 integral membrane protein 2B [Pan paniscus]
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVA---VDCKDPDD---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFALQ-----------------PDD
VYYCGIKYIKDDVILNEPS--------------ADAPAA-LY-----------------Q
TIEENIKI-FEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPRNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENIDHLGFFIYRLCHDKETYKL
QRRETIKGIQKREASNCFAIRHFE----NKFAVETLICS--------------
>XP_011278441.1 integral membrane protein 2B [Felis catus]
MVKVTFNSALAQKEAKKDDPKCGEEALIIPPDAVA---VDCKDPDE---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFALQ-----------------PDD
VYYCGIKYIKDDVILNEPS--------------ADAPAA-RY-----------------Q
TIEENIKI-FEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPRNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENVDHLGFFIYRLCHDKETYKL
QRRETIKGIQKREVSNCVTIRHFE----NKFAVETVICP--------------
>XP_004054544.1 integral membrane protein 2B [Gorilla gorilla gorilla]
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVA---VDCKDPDD---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFALQ-----------------PDD
VYYCGIKYIKDDVILNEPS--------------ADAPAA-LY-----------------Q
TIEENIKI-FEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPRNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENIDHLGFFIYRLCHDKETYKL
QRRETIKGIQKREASNCFAIRHFE----NKFAVETLICS--------------
>XP_005501874.1 integral membrane protein 2B isoform X1 [Columba livia]
MVKVSFNSALAQKEAAKKEEEN-SQVLILPP--------DAKDPED---------AVPVG
QR-RAWC-----WCMYFGLAFMLAGVILGGAYLYKYFAFQ-----------------QNG
VYFCGIKYIEDGLSLPEPG--------------AEAQSA-RY-----------------H
TIEQNIQI-LEEEDVEFISVPVPEFADSDPADIVHDFHRRLTAYLDLSLDKCYVIPLNTS
VVMPPKNFLELLINIKAGTYLPQSYLIHEQM-IVTDRIENVDQLGFFIYRLCRGKETYKL
QRKEAMKGIQKREAVNCRKIRHFE----NRFAMETLICE-------------Q
>XP_017912239.1 PREDICTED: integral membrane protein 2B [Capra hircus]
MVKVTFNSALAQKEAKKDESKSGEEALIIPPDAVA---VDCKDPDE---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFAFQ-----------------PDD
VYYCGIKYIKDDVILNEPS--------------ADAPAS-RY-----------------Q
TIEENIKI-FEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPKNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENIDHLGFYIYRLCHDKETYKL
QRRETIKGIQKRAASACVTIRHFE----NKFAVETLICS--------------
>XP_014378463.1 integral membrane protein 2B [Alligator sinensis]
MGSLCVWHMV------------------------------NQDPDD---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFAFQ-----------------QGG
VYFCGLQYIEDGLTLTEPD--------------PEAPAA-RY-----------------H
TIEENIQI-LEEEDVEFISVPVPEFADSDPADIVHDFHRRLTAYLDLSLDKCYVIPLNTS
VVMPPKNFLELLINIKAGTYLPQSYLIHEQM-IVTDRIENVDQLGFFIYRLCRGKETYKL
QRKEIMKGIQKREASNCRKIRHFE----NRFAMETLICE-------------Q
>XP_006261837.1 PREDICTED: integral membrane protein 2B [Alligator mississippiensis]
MVKVSFSSALAQKEAAKKEEEN-SQVLILPT--------AAKDPDD---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFAFQ-----------------QGG
VYFCGLQYIEDGLTLTEPD--------------PEAPAA-RY-----------------H
TIEENIQI-LEEEDVEFISVPVPEFADSDPADIVHDFHRRLTAYLDLSLDKCYVIPLNTS
VVMPPKNFLELLINIKAGTYLPQSYLIHEQM-IVTDRIENVDQLGFFIYRLCRGKETYKL
QRKEIMKGIQKREASNCRKIRHFE----NRFAMETLICE-------------Q
>XP_015821286.1 PREDICTED: integral membrane protein 2B [Nothobranchius furzeri]
MVKVSFNAALAQKDVKKD-----FETLIPA---------ENRDTEA---------ALVVR
QRSRAWC-----WCVCLGIALFLSGVVVAGAYLYRYYVVEGHRNLISSSHWADPQQQDNE
VFICGVNYHENDYMITEEEE------------MMEEQSF-RQ-----------------R
LLQERIQV-LVPDQVEIIHVPVPDFEDGDPADIVHDFQRRLTAYLDLSLDKCYVIPLNTS
VVMPPTDLLDLLINVKAGTYLPQSYLVHEEM-VVTERLENIENLGAFIYTLCRGKDTYKL
QRRDRILGMQKREALTCHKIRHFE----NTFVVETLICE-------------P
>XP_020732181.1 integral membrane protein 2B [Odocoileus virginianus texanus]
MVKVTFNSALAQKEAKKDEAKSGEEALIIPPDAVA---VDCKDPDE---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFALQ-----------------PDD
VYYCGIKYIKDDVILNEPS--------------ADAPAA-RY-----------------Q
TIEENIKI-FEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPKNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENIDHLGFYIYRLCHDKETYKL
QRRETIKGIQKREASICATIRHFE----NRFAVETLICS--------------
>XP_040197170.1 integral membrane protein 2B [Rana temporaria]
MVKLAFNSSLAQKDAKKDDEN--SEVLIIT---------DNKEVEE---------VVPLG
QR-RAWC-----WCMCFGLAFMLAGIVLGGAYLYRYFVSQ------------------RG
VYFCGIRYTDDDMTLAEPY--------------ADSSRI-RY-----------------H
SFKERIQI-LEDEEVELINVPVPEFADSDPADIVHDFHRKLTAYLDLSLNKCYVIPLNTS
IVMPPKNFLELLINIKAGTYLPQSYLIHEQM-VVTDRIENVDQLGVFIRRLCQDKETYKL
QRREPVRGRQKRDLQGCFRINHFE----NKFAVQTMICH--------------
>XP_043334233.1 integral membrane protein 2B [Cervus canadensis]
MVKVTFNSALAQKEAKKDEAKSGEEALIIPPDAVA---VDCKDPDE---------VVPVG
QR-RAWC-----WCMCFGLAFMLAGVILGGAYLYKYFALQ-----------------PDD
VYYCGIKYIKDDVILNEPS--------------ADAPAA-RY-----------------Q
TIEENIKI-FEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPKNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENIDHLGFYIYRLCHDKETYKL
QRRETIKGIQKREASVCATIRHFE----NRFAVETLICS--------------
>KAF4025594.1 hypothetical protein G4228_017608 [Cervus hanglu yarkandensis]
MVKVTFNSALAQKEAKKDEAKSGEEALIIPPDAVA---VDCK------------------
---------------------------------------------------------PDD
VYYCGIKYIKDDVILNEPS--------------ADAPAA-RY-----------------Q
TIEENIKI-FEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTS
IVMPPKNLLELLINIKAGTYLPQSYLIHEHM-VITDRIENIDHLGFYIYRLCHDKETYKL
QRRETIKGIQKREASVCATIRHFE----NRFAVETLICS--------------
>NP_001080382.1 integral membrane protein 2B L homeolog [Xenopus laevis]
MVKLTFNSTLGQKDGKKEDEN--NEVLIIP---------EAKEPED---------VVPLG
QR-RAWC-----WCMCFGLAFMLAGIVLGSAYLYKYFAMQ------------------RG
VYFCGIRYLEDDAALTEPY--------------AETP-V-RY-----------------H
SFRESIQI-LEEEEVELINVPVPEFADSDPVDIVHDFHRKLTAYLDLNLNKCYVIPLNTS
IVMPPKNFLELLLNIKAGTYLPQSYLVHEQM-IVTDRIENVDQLGFFIYRLCRDKDTYKL
QRKETIRGFHKREAENCHTIRHFA----NKFPVETQICE-------------H
>XP_023806972.1 integral membrane protein 2B isoform X2 [Oryzias latipes]
MVKVSFNSALAQKEVKKD-----DESLIPEE-------EVEVDVET---------AVLVR
RQSRAWC-----WCVCLGVALMLSGVLIAGAYLFRYYTGP-----------------GEP
VFFCGVNYIEDDYMIRDEE--------------VDVPSS--L-----------------R
ELEMTIRI-LEEEQVEIISVPVPNFEDGDPADIVHDFDRRMTAYLDLSLDKCYVIPLNTS
AVMPPRDLLDLLINVKAGTYLPQSYLVHEEM-VVTERLERVDQLGYFIYNLCRNKETYKL
QRRDRILGMQKREVQNCRKIRHFE----NNFVVETQICE-------------L
>XP_030283386.1 integral membrane protein 2B isoform X2 [Sparus aurata]
MVKVSFNSALGQKDVKKD-----AETLLTE---------EDKDAEA---------ALPVR
QQSRAWC-----WCMCLGLALMLSGVVVGGAYLYRYYILE-----------------EGH
VFVCGVNYREEDFMIREEEE-----------VEVELPNQFPL-----------------R
QLEERIRV-LEDEQVELINVPVPEFDDGDPADIVHDFQRKLTAYLDLSLNKCYVIPLNTS
IVMPPRDFLELLVNVKAGTYLPQSYLIHEEM-IVTERLEHVDQLGYFIYNLCRGKDTYKL
QRRDRILGMQKREALNCHKIRHFG----SRVVVETLICE-------------P
>CAE1261877.1 ITM2B [Sepia pharaonis]
MTIYKF--QQVGKKSKED-----EQPETVKEPLTA---EKEKDPEASKLPKAI-HVTFIP
RRSKTCIN----MSLMFISLIVLSGGAIGGIYLYGHLKHT------------------VI
RGRCGVIYTQDLFMQKDPP--------------VPIASGFRYNDQNPSKNDMSV-----S
FFEETIEI--TDDYYE--RVEIPKFDECENAIVLHDFERNFTAIVDKDIGRCFIMKLNRS
VIAPPKDLWDLLHKLKSGYYMPRATVVRETYSVEIPALDNLSILGPYVRSECSRFTTFML
RK--IINQRLKRSAESLSNSEHYGFADHKQRLWKLKVFF-------------P
>XP_026301546.1 integral membrane protein 2C [Apis mellifera]
MTFITK--AITEKKADKK-----EQSLFVQKNPAE---NGKRDAEAQCLKSDVGGHYFVS
KRSIYRIHVTATFLLFLVALMILIIGVIGGLYIYRQYART-----------------QMH
KFKTGWYSIPYDKSNKPPYAKDAVHQGLIADSDLILKSLTRATEREAMDIEKNVDSDIRS
FFKERFEIDLENEHYE--KIDVPDFRGGRQGRFIHDFSINKTGIIDIDGESCFVMPLNRQ
TVLPPRNMYDLLRKMYNGYYEVNTQIVRETMKVITPPITDLSVVGTYIARECQDFPTYML
TK--VTSNVVKRSISS-GVFGQFA----GKNIIEFDILNLDDVSEYNKKSSQN
>XP_038051184.1 integral membrane protein 2B-like [Patiria miniata]
MKIYAADGKVQQAKVVYN----GDTYTTVAVPTKAGQYECKCKDEDLKLTKSS-HPKVTP
NHHQTRC-----WSCGLSACLIFSIVASVGLFVLLYSAAR-----------------PVS
--------IEDSFSVGECE--------------LPILPD----ERQP------------Y
GYKQHMAA-DKETMTE--TFDIPEINANHPATIMHDFYNEVTVYLDRLEGICFVMKLNTT
QVVPPRYLLEAFIRYKRGDFALDIDTIQETMEVQTPPIADISSLGLGTELLCHELPTYWL
VKPGTPVLRKRSIPSDGHHVTYFN----GLHMIDLTVTN-----------GGV

BMGE Cleaned alignment of selected proteins

>sp|Q9Y287|ITM2B_HUMAN Integral membrane protein 2B OS=Homo sapiens OX=9606 GN=ITM2B PE=1 SV=1
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAAQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS
>sp|Q9Y287-2|ITM2B_HUMAN Isoform 2 of Integral membrane protein 2B OS=Homo sapiens OX=9606 GN=ITM2B
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFALQ--------------------------------------------------------------------------------------------------------AGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS
>tr|Q803H7|Q803H7_DANRE Integral membrane protein 2 OS=Danio rerio OX=7955 GN=itm2ba PE=2 SV=1
MVKLTFNSALGQKDLKKEEK---DEALIP-------HDLDVEDVLRVRQQWCMCLGLALILSGVVVGGAYLYRYYFIEEERMYFCGVNYREENYKMQDSQMDLPAAKRIEEKVRVLEDEGVELINIPVPKFSDSDPADIVHDFNRRLTAYLDLRLNKCYVIPLNTSVVMPPKDFLELLVNIKAGTYLPQSYLVREQMMVTGKVEHVDQLGYFIYGLCRGRDTYKLERRETVLGIQKREALNCHKILHFENKFVVETLICE
>NP_032436.1 integral membrane protein 2B precursor [Mus musculus]
MVKVTFNSALAQKEAKKDEPKSSEEALIVPPDAVAVDCKDPGDVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGLKYIKDDVILNEPSADAPAAQTIEENIKIFEEDAVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHMVITDRIENVDNLGFFIYRLCHDKETYKLQRRETIRGIQKREASNCFTIRHFENKFAVETLICS
>NP_001006964.1 integral membrane protein 2B [Rattus norvegicus]
MVKVTFNSALAQKEAKKDEPKSSEEALIAPPDAVAVDCKDPDDVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGLKYIKDDVILSEPSADAPAAQTIEENIKIFEEDAVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENVDHLGFFIYRLCHDKETYKLQRRETIRGIQKREASNCFTIRHFENKFAVETLICS
>NP_990416.2 integral membrane protein 2B [Gallus gallus]
MVKVSFNSALAQKEAAKKEEEN-SQVLILPP-----DAKEPEDVVPAGQRWCMCFGLAFMLAGVILGGAYLYKYFAFQQGGVYFCGIKYIEDGLSLPESGAEAQSAHTIEQNIQILEEEDVEFISVPVPEFADSDPADIVHDFHRRLTAYLDLSLDKCYVIPLNTSVVMPPKNFLELLINIKAGTYLPQSYLIHEQMIVTDRIENVDQLGFFIYRLCRGKETYKLQRKEAMKGIQKREAVNCRKIRHFENRFAMETLICE
>NP_001092017.1 integral membrane protein 2B [Pan troglodytes]
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAAQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS
>XP_038286861.1 integral membrane protein 2B [Canis lupus familiaris]
MVKVTFNSALAQKEAKKDEPKCGEEALIIPPDAVAVDCKDPDEVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVLLNEPSADAPAAQTIEENIKIFEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIRGIQKREVSNCVTIRHFENKFAVETVICP
>NP_001030265.1 integral membrane protein 2B [Bos taurus]
MVKVTFNSALAQKEAKKDESKSGEEALIIPPDAVAVDCKDPDEVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFAFQPDDVYYCGIKYIKDDVILNEPSADAPASQTIEENIKIFEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFYIYRLCHDKETYKLQRRETIKGIQKRSADVCVTIRHFENRFAVETLICP
>XP_005652396.2 integral membrane protein 2B isoform X1 [Sus scrofa]
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDTVAVDCKDPDEVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPPANAPAAQTIEENIKIFEEDGVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFYIYRLCHDKETYKLQRKETVKGIQKREASNCATIRHFENKFAVETLICS
>NP_001127776.1 integral membrane protein 2B [Ovis aries]
MVKVTFNSALAQKEAKKDESKSGEEALIIPPDAVAVDCKDPDEVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFAFQPDDVYYCGIKYIKDDVILNEPSADAPASQTIEENIKIFEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFYIYRLCHDKETYKLQRRDTIKGIQKRAASTCVTIRHFENKFAVETLICS
>XP_002720768.1 PREDICTED: integral membrane protein 2B [Oryctolagus cuniculus]
MVKVTFNSALAQKEAKKDDPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAAQTIEENIKIFEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLLHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRDTIKGIQKREVSDCVTIRHFENKFAVETLICS
>XP_002824307.1 integral membrane protein 2B [Pongo abelii]
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAAQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS
>XP_010727120.1 integral membrane protein 2B [Meleagris gallopavo]
----------------------------------------------------MCFGLAFMLAGVILGGAYLYKYFAFQQGGVYFCGIKYIEDGLSLPESGAEAQSAHTIEQNIQILEEEDVEFISVPVPEFADSDPADIVHDFHRRLTAYLDLSLDKCYVIPLNTSVVMPPKNFLELLINIKAGTYLPQSYLIHEQMIVTDRIENVDQLGFFIYRLCRGKETYKLQRKEAMKGIQKREAVNCRKIRHFENRFAMETLICE
>XP_034792608.1 integral membrane protein 2B [Pan paniscus]
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAAQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS
>XP_011278441.1 integral membrane protein 2B [Felis catus]
MVKVTFNSALAQKEAKKDDPKCGEEALIIPPDAVAVDCKDPDEVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAAQTIEENIKIFEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENVDHLGFFIYRLCHDKETYKLQRRETIKGIQKREVSNCVTIRHFENKFAVETVICP
>XP_004054544.1 integral membrane protein 2B [Gorilla gorilla gorilla]
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAAQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS
>XP_005501874.1 integral membrane protein 2B isoform X1 [Columba livia]
MVKVSFNSALAQKEAAKKEEEN-SQVLILPP-----DAKDPEDAVPVGQRWCMYFGLAFMLAGVILGGAYLYKYFAFQQNGVYFCGIKYIEDGLSLPEPGAEAQSAHTIEQNIQILEEEDVEFISVPVPEFADSDPADIVHDFHRRLTAYLDLSLDKCYVIPLNTSVVMPPKNFLELLINIKAGTYLPQSYLIHEQMIVTDRIENVDQLGFFIYRLCRGKETYKLQRKEAMKGIQKREAVNCRKIRHFENRFAMETLICE
>XP_017912239.1 PREDICTED: integral membrane protein 2B [Capra hircus]
MVKVTFNSALAQKEAKKDESKSGEEALIIPPDAVAVDCKDPDEVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFAFQPDDVYYCGIKYIKDDVILNEPSADAPASQTIEENIKIFEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFYIYRLCHDKETYKLQRRETIKGIQKRAASACVTIRHFENKFAVETLICS
>XP_014378463.1 integral membrane protein 2B [Alligator sinensis]
MGSLCVWHMV---------------------------NQDPDDVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFAFQQGGVYFCGLQYIEDGLTLTEPDPEAPAAHTIEENIQILEEEDVEFISVPVPEFADSDPADIVHDFHRRLTAYLDLSLDKCYVIPLNTSVVMPPKNFLELLINIKAGTYLPQSYLIHEQMIVTDRIENVDQLGFFIYRLCRGKETYKLQRKEIMKGIQKREASNCRKIRHFENRFAMETLICE
>XP_006261837.1 PREDICTED: integral membrane protein 2B [Alligator mississippiensis]
MVKVSFSSALAQKEAAKKEEEN-SQVLILPT-----AAKDPDDVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFAFQQGGVYFCGLQYIEDGLTLTEPDPEAPAAHTIEENIQILEEEDVEFISVPVPEFADSDPADIVHDFHRRLTAYLDLSLDKCYVIPLNTSVVMPPKNFLELLINIKAGTYLPQSYLIHEQMIVTDRIENVDQLGFFIYRLCRGKETYKLQRKEIMKGIQKREASNCRKIRHFENRFAMETLICE
>XP_015821286.1 PREDICTED: integral membrane protein 2B [Nothobranchius furzeri]
MVKVSFNAALAQKDVKKD-----FETLIPA------ENRDTEAALVVRQRWCVCLGIALFLSGVVVAGAYLYRYYVVEDNEVFICGVNYHENDYMITEEEMEEQSFRLLQERIQVLVPDQVEIIHVPVPDFEDGDPADIVHDFQRRLTAYLDLSLDKCYVIPLNTSVVMPPTDLLDLLINVKAGTYLPQSYLVHEEMVVTERLENIENLGAFIYTLCRGKDTYKLQRRDRILGMQKREALTCHKIRHFENTFVVETLICE
>XP_020732181.1 integral membrane protein 2B [Odocoileus virginianus texanus]
MVKVTFNSALAQKEAKKDEAKSGEEALIIPPDAVAVDCKDPDEVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAAQTIEENIKIFEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFYIYRLCHDKETYKLQRRETIKGIQKREASICATIRHFENRFAVETLICS
>XP_040197170.1 integral membrane protein 2B [Rana temporaria]
MVKLAFNSSLAQKDAKKDDEN--SEVLIIT------DNKEVEEVVPLGQRWCMCFGLAFMLAGIVLGGAYLYRYFVSQ-RGVYFCGIRYTDDDMTLAEPYADSSRIHSFKERIQILEDEEVELINVPVPEFADSDPADIVHDFHRKLTAYLDLSLNKCYVIPLNTSIVMPPKNFLELLINIKAGTYLPQSYLIHEQMVVTDRIENVDQLGVFIRRLCQDKETYKLQRREPVRGRQKRDLQGCFRINHFENKFAVQTMICH
>XP_043334233.1 integral membrane protein 2B [Cervus canadensis]
MVKVTFNSALAQKEAKKDEAKSGEEALIIPPDAVAVDCKDPDEVVPVGQRWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAAQTIEENIKIFEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFYIYRLCHDKETYKLQRRETIKGIQKREASVCATIRHFENRFAVETLICS
>KAF4025594.1 hypothetical protein G4228_017608 [Cervus hanglu yarkandensis]
MVKVTFNSALAQKEAKKDEAKSGEEALIIPPDAVAVDCK---------------------------------------PDDVYYCGIKYIKDDVILNEPSADAPAAQTIEENIKIFEEDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFYIYRLCHDKETYKLQRRETIKGIQKREASVCATIRHFENRFAVETLICS
>NP_001080382.1 integral membrane protein 2B L homeolog [Xenopus laevis]
MVKLTFNSTLGQKDGKKEDEN--NEVLIIP------EAKEPEDVVPLGQRWCMCFGLAFMLAGIVLGSAYLYKYFAMQ-RGVYFCGIRYLEDDAALTEPYAETP-VHSFRESIQILEEEEVELINVPVPEFADSDPVDIVHDFHRKLTAYLDLNLNKCYVIPLNTSIVMPPKNFLELLLNIKAGTYLPQSYLVHEQMIVTDRIENVDQLGFFIYRLCRDKDTYKLQRKETIRGFHKREAENCHTIRHFANKFPVETQICE
>XP_023806972.1 integral membrane protein 2B isoform X2 [Oryzias latipes]
MVKVSFNSALAQKEVKKD-----DESLIPEE----EVEVDVETAVLVRRQWCVCLGVALMLSGVLIAGAYLFRYYTGPGEPVFFCGVNYIEDDYMIRDEEVDVPSSRELEMTIRILEEEQVEIISVPVPNFEDGDPADIVHDFDRRMTAYLDLSLDKCYVIPLNTSAVMPPRDLLDLLINVKAGTYLPQSYLVHEEMVVTERLERVDQLGYFIYNLCRNKETYKLQRRDRILGMQKREVQNCRKIRHFENNFVVETQICE
>XP_030283386.1 integral membrane protein 2B isoform X2 [Sparus aurata]
MVKVSFNSALGQKDVKKD-----AETLLTE------EDKDAEAALPVRQQWCMCLGLALMLSGVVVGGAYLYRYYILEEGHVFVCGVNYREEDFMIREEEVELPNQRQLEERIRVLEDEQVELINVPVPEFDDGDPADIVHDFQRKLTAYLDLSLNKCYVIPLNTSIVMPPRDFLELLVNVKAGTYLPQSYLIHEEMIVTERLEHVDQLGYFIYNLCRGKDTYKLQRRDRILGMQKREALNCHKIRHFGSRVVVETLICE
>CAE1261877.1 ITM2B [Sepia pharaonis]
MTIYKF--QQVGKKSKED-----EQPETVKEPLTAEKEKDPEAVTFIPRRMSLMFISLIVLSGGAIGGIYLYGHLKHT-VIRGRCGVIYTQDLFMQKDPPVPIASGSFFEETIEI-TDDYYE--RVEIPKFDECENAIVLHDFERNFTAIVDKDIGRCFIMKLNRSVIAPPKDLWDLLHKLKSGYYMPRATVVRETYVEIPALDNLSILGPYVRSECSRFTTFMLRK--IINQRLKRSAESLSNSEHYGKQRLWKLKVFF
>XP_026301546.1 integral membrane protein 2C [Apis mellifera]
MTFITK--AITEKKADKK-----EQSLFVQKNPAENGKRDAEAHYFVSKRFLLFLVALMILIIGVIGGLYIYRQYARTQMHKFKTGWYSIPYDKSNKPPYLILKSLSFFKERFEILENEHYE--KIDVPDFRGGRQGRFIHDFSINKTGIIDIDGESCFVMPLNRQTVLPPRNMYDLLRKMYNGYYEVNTQIVRETMVITPPITDLSVVGTYIARECQDFPTYMLTK--VTSNVVKRSISS-GVFGQFAGKNIIEFDILN
>XP_038051184.1 integral membrane protein 2B-like [Patiria miniata]
MKIYAADGKVQQAKVVYN----GDTYTTVAVPTKAECKCKDEDPKVTPNHWSCGLSACLIFSIVASVGLFVLLYSAARPVS--------IEDSFSVGECELPILPDYGYKQHMAADKETMTE--TFDIPEINANHPATIMHDFYNEVTVYLDRLEGICFVMKLNTTQVVPPRYLLEAFIRYKRGDFALDIDTIQETMVQTPPIADISSLGLGTELLCHELPTYWLVKPGTPVLRKRSIPSDGHHVTYFNGLHMIDLTVTN

PhyML tree of selected proteins

((((((XP_005501874_1_integral_membrane_protein_2B_isoform_X1__Columba_livia_:0.01258185,(NP_990416_2_integral_membrane_protein_2B__Gallus_gallus_:0.00000001,XP_010727120_1_integral_membrane_protein_2B__Meleagris_gallopavo_:0.00000001):0.01284202):0.03417724,(XP_014378463_1_integral_membrane_protein_2B__Alligator_sinensis_:0.05725188,XP_006261837_1_PREDICTED__integral_membrane_protein_2B__Alligator_mississippiensis_:0.00000001):0.0390472):0.08823626,((NP_001080382_1_integral_membrane_protein_2B_L_homeolog__Xenopus_laevis_:0.11591624,(XP_040197170_1_integral_membrane_protein_2B__Rana_temporaria_:0.07644081,(XP_038051184_1_integral_membrane_protein_2B_like__Patiria_miniata_:3.01292841,(CAE1261877_1_ITM2B__Sepia_pharaonis_:1.20266057,XP_026301546_1_integral_membrane_protein_2C__Apis_mellifera_:1.42532814):0.74289595):1.16963224):0.11015535):0.09073247,(tr_Q803H7_Q803H7_DANRE_Integral_membrane_protein_2_OS_Danio_rerio_OX_7955_GN_itm2ba_PE_2_SV_1:0.2350146,(XP_030283386_1_integral_membrane_protein_2B_isoform_X2__Sparus_aurata_:0.07610948,(XP_015821286_1_PREDICTED__integral_membrane_protein_2B__Nothobranchius_furzeri_:0.19086104,XP_023806972_1_integral_membrane_protein_2B_isoform_X2__Oryzias_latipes_:0.23341665):0.09003146):0.12767444):0.31254257):0.04935405):0.18143458,((XP_034792608_1_integral_membrane_protein_2B__Pan_paniscus_:0.00000001,(XP_002824307_1_integral_membrane_protein_2B__Pongo_abelii_:0.00000001,(NP_001092017_1_integral_membrane_protein_2B__Pan_troglodytes_:0.00000001,(sp_Q9Y287_ITM2B_HUMAN_Integral_membrane_protein_2B_OS_Homo_sapiens_OX_9606_GN_ITM2B_PE_1_SV_1:0.00000001,XP_004054544_1_integral_membrane_protein_2B__Gorilla_gorilla_gorilla_:0.00000001):0.00000001):0.00000001):0.00000001):0.00000001,sp_Q9Y287_2_ITM2B_HUMAN_Isoform_2_of_Integral_membrane_protein_2B_OS_Homo_sapiens_OX_9606_GN_ITM2B:0.00000001):0.00030724):0.00785542,((XP_005652396_2_integral_membrane_protein_2B_isoform_X1__Sus_scrofa_:0.02499176,(XP_020732181_1_integral_membrane_protein_2B__Odocoileus_virginianus_texanus_:0.00000001,(KAF4025594_1_hypothetical_protein_G4228_017608__Cervus_hanglu_yarkandensis_:0.00000001,(XP_043334233_1_integral_membrane_protein_2B__Cervus_canadensis_:0.00000001,(NP_001030265_1_integral_membrane_protein_2B__Bos_taurus_:0.01087646,(XP_017912239_1_PREDICTED__integral_membrane_protein_2B__Capra_hircus_:0.00000001,NP_001127776_1_integral_membrane_protein_2B__Ovis_aries_:0.00797067):0.00936579):0.0201016):0.00000001):0.00399533):0.01641573):0.01039376,(XP_002720768_1_PREDICTED__integral_membrane_protein_2B__Oryctolagus_cuniculus_:0.01495997,(XP_011278441_1_integral_membrane_protein_2B__Felis_catus_:0.0058465,XP_038286861_1_integral_membrane_protein_2B__Canis_lupus_familiaris_:0.01041854):0.01558911):0.00749034):0.00459835):0.0245116,NP_001006964_1_integral_membrane_protein_2B__Rattus_norvegicus_:0.00801048,NP_032436_1_integral_membrane_protein_2B_precursor__Mus_musculus_:0.01243271);

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)