Click here to access PB0216 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0216 Q9Y287 Integral membrane protein 2B ITM2B ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, RDGCA, imBRI2 Homo_sapiens Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.

DomainsGene Ontology
GO:0001540 (enables) amyloid-beta binding
GO:0005515 (enables) protein binding
GO:0005524 (enables) ATP binding
GO:0007399 (involved in) nervous system development
GO:0042985 (involved in) negative regulation of amyloid precursor protein biosynthetic process
GO:0000139 (located in) Golgi membrane
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005768 (located in) endosome
GO:0005794 (located in) Golgi apparatus
GO:0005886 (located in) plasma membrane
GO:0010008 (located in) endosome membrane
GO:0016020 (located in) membrane
GO:0016021 (located in) integral component of membrane
GO:0030660 (located in) Golgi-associated vesicle membrane
GO:0031301 (located in) integral component of organelle membrane
GO:0043231 (located in) intracellular membrane-bounded organelle
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)