Click here to access PB0215 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0215 P07093 Glia-derived nexin SERPINE2 GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI, serpin family E member 2 Homo_sapiens Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

DomainsGene Ontology
PF00079 (Serpin)
GO:0062023 (colocalizes with) collagen-containing extracellular matrix
GO:0004867 (enables) serine-type endopeptidase inhibitor activity
GO:0005102 (enables) signaling receptor binding
GO:0005515 (enables) protein binding
GO:0005539 (enables) glycosaminoglycan binding
GO:0008201 (enables) heparin binding
GO:0030414 (enables) peptidase inhibitor activity
GO:0007399 (involved in) nervous system development
GO:0007596 (involved in) blood coagulation
GO:0008285 (involved in) negative regulation of cell population proliferation
GO:0009611 (involved in) response to wounding
GO:0010466 (involved in) negative regulation of peptidase activity
GO:0010544 (involved in) negative regulation of platelet activation
GO:0010757 (involved in) negative regulation of plasminogen activation
GO:0010766 (involved in) negative regulation of sodium ion transport
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0010955 (involved in) negative regulation of protein processing
GO:0014067 (involved in) negative regulation of phosphatidylinositol 3-kinase signaling
GO:0021683 (involved in) cerebellar granular layer morphogenesis
GO:0030154 (involved in) cell differentiation
GO:0030163 (involved in) protein catabolic process
GO:0030168 (involved in) platelet activation
GO:0030195 (involved in) negative regulation of blood coagulation
GO:0030308 (involved in) negative regulation of cell growth
GO:0030334 (involved in) regulation of cell migration
GO:0032940 (involved in) secretion by cell
GO:0033363 (involved in) secretory granule organization
GO:0042177 (involved in) negative regulation of protein catabolic process
GO:0042628 (involved in) mating plug formation
GO:0045861 (involved in) negative regulation of proteolysis
GO:0045879 (involved in) negative regulation of smoothened signaling pathway
GO:0048505 (involved in) regulation of timing of cell differentiation
GO:0048711 (involved in) positive regulation of astrocyte differentiation
GO:0050974 (involved in) detection of mechanical stimulus involved in sensory perception
GO:0051966 (involved in) regulation of synaptic transmission, glutamatergic
GO:0060291 (involved in) long-term synaptic potentiation
GO:0060384 (involved in) innervation
GO:0061108 (involved in) seminal vesicle epithelium development
GO:0090331 (involved in) negative regulation of platelet aggregation
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005829 (located in) cytosol
GO:0031091 (located in) platelet alpha granule
GO:0031232 (located in) extrinsic component of external side of plasma membrane
GO:0031594 (located in) neuromuscular junction
GO:1903561 (located in) extracellular vesicle

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)