Click here to access PB0213 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0213 O60565 Gremlin-1 GREM1v C15DUPq, CKTSF1B1, CRAC1, CRCS4, DAND2, DRM, DUP15q, GREMLIN, HMPS, HMPS1, IHG-2, MPSH, PIG2, DAN family BMP antagonist Homo_sapiens Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity).

DomainsGene Ontology
PF03045 (DAN)
GO:0062023 (colocalizes with) collagen-containing extracellular matrix
GO:0005125 (enables) cytokine activity
GO:0005515 (enables) protein binding
GO:0016015 (enables) morphogen activity
GO:0030297 (enables) transmembrane receptor protein tyrosine kinase activator activity
GO:0036122 (enables) BMP binding
GO:0042803 (enables) protein homodimerization activity
GO:0043184 (enables) vascular endothelial growth factor receptor 2 binding
GO:0048018 (enables) receptor ligand activity
GO:0000902 (involved in) cell morphogenesis
GO:0001525 (involved in) angiogenesis
GO:0002042 (involved in) cell migration involved in sprouting angiogenesis
GO:0002092 (involved in) positive regulation of receptor internalization
GO:0002689 (involved in) negative regulation of leukocyte chemotaxis
GO:0003337 (involved in) mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006915 (involved in) apoptotic process
GO:0007165 (involved in) signal transduction
GO:0007171 (involved in) activation of transmembrane receptor protein tyrosine kinase activity
GO:0007267 (involved in) cell-cell signaling
GO:0008284 (involved in) positive regulation of cell population proliferation
GO:0009887 (involved in) animal organ morphogenesis
GO:0009954 (involved in) proximal/distal pattern formation
GO:0010717 (involved in) regulation of epithelial to mesenchymal transition
GO:0030199 (involved in) collagen fibril organization
GO:0030308 (involved in) negative regulation of cell growth
GO:0030326 (involved in) embryonic limb morphogenesis
GO:0030502 (involved in) negative regulation of bone mineralization
GO:0030514 (involved in) negative regulation of BMP signaling pathway
GO:0032331 (involved in) negative regulation of chondrocyte differentiation
GO:0033689 (involved in) negative regulation of osteoblast proliferation
GO:0038098 (involved in) sequestering of BMP from receptor via BMP binding
GO:0043066 (involved in) negative regulation of apoptotic process
GO:0043542 (involved in) endothelial cell migration
GO:0045668 (involved in) negative regulation of osteoblast differentiation
GO:0045766 (involved in) positive regulation of angiogenesis
GO:0045892 (involved in) negative regulation of DNA-templated transcription
GO:0045893 (involved in) positive regulation of DNA-templated transcription
GO:0045944 (involved in) positive regulation of transcription by RNA polymerase II
GO:0046851 (involved in) negative regulation of bone remodeling
GO:0048263 (involved in) determination of dorsal identity
GO:0051092 (involved in) positive regulation of NF-kappaB transcription factor activity
GO:0051893 (involved in) regulation of focal adhesion assembly
GO:0051973 (involved in) positive regulation of telomerase activity
GO:0055007 (involved in) cardiac muscle cell differentiation
GO:0060173 (involved in) limb development
GO:0060379 (involved in) cardiac muscle cell myoblast differentiation
GO:0060394 (involved in) negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060676 (involved in) ureteric bud formation
GO:0061098 (involved in) positive regulation of protein tyrosine kinase activity
GO:0090027 (involved in) negative regulation of monocyte chemotaxis
GO:0090090 (involved in) negative regulation of canonical Wnt signaling pathway
GO:0090190 (involved in) positive regulation of branching involved in ureteric bud morphogenesis
GO:0090291 (involved in) negative regulation of osteoclast proliferation
GO:1900086 (involved in) positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900155 (involved in) negative regulation of bone trabecula formation
GO:1900158 (involved in) negative regulation of bone mineralization involved in bone maturation
GO:1901224 (involved in) positive regulation of NIK/NF-kappaB signaling
GO:2000273 (involved in) positive regulation of signaling receptor activity
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0009986 (located in) cell surface

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)