Click here to access PB0212 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0212 P02753 Retinol-binding protein 4 RBP4 MCOPCB10, RDCCAS Homo_sapiens Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496).

DomainsGene Ontology
PF00061 (Lipocalin)
GO:0005501 (enables) retinoid binding
GO:0005515 (enables) protein binding
GO:0016918 (enables) retinal binding
GO:0019841 (enables) retinol binding
GO:0034632 (enables) retinol transmembrane transporter activity
GO:0001654 (involved in) eye development
GO:0002639 (involved in) positive regulation of immunoglobulin production
GO:0006094 (involved in) gluconeogenesis
GO:0007507 (involved in) heart development
GO:0007601 (involved in) visual perception
GO:0030277 (involved in) maintenance of gastrointestinal epithelium
GO:0030324 (involved in) lung development
GO:0032024 (involved in) positive regulation of insulin secretion
GO:0032526 (involved in) response to retinoic acid
GO:0034633 (involved in) retinol transport
GO:0042572 (involved in) retinol metabolic process
GO:0042593 (involved in) glucose homeostasis
GO:0048562 (involved in) embryonic organ morphogenesis
GO:0048706 (involved in) embryonic skeletal system development
GO:0048738 (involved in) cardiac muscle tissue development
GO:0048807 (involved in) female genitalia morphogenesis
GO:0050896 (involved in) response to stimulus
GO:0060044 (involved in) negative regulation of cardiac muscle cell proliferation
GO:0060059 (involved in) embryonic retina morphogenesis in camera-type eye
GO:0060065 (involved in) uterus development
GO:0060068 (involved in) vagina development
GO:0060157 (involved in) urinary bladder development
GO:0060347 (involved in) heart trabecula formation
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)