Click here to access PB0211 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0211 P08758 Annexin A5 ANXA5 ANX5, CPB-I, ENX2, HEL-S-7, PP4, RPRGL3, VAC-alph Homo_sapiens This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

DomainsGene Ontology
PF00191 (4_Annexin)
GO:0004859 (enables) phospholipase inhibitor activity
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0005543 (enables) phospholipid binding
GO:0005544 (enables) calcium-dependent phospholipid binding
GO:0007165 (involved in) signal transduction
GO:0007596 (involved in) blood coagulation
GO:0007599 (involved in) hemostasis
GO:0010033 (involved in) response to organic substance
GO:0043066 (involved in) negative regulation of apoptotic process
GO:0043086 (involved in) negative regulation of catalytic activity
GO:0050819 (involved in) negative regulation of coagulation
GO:0005576 (located in) extracellular region
GO:0005737 (located in) cytoplasm
GO:0005829 (located in) cytosol
GO:0005925 (located in) focal adhesion
GO:0009897 (located in) external side of plasma membrane
GO:0016020 (located in) membrane
GO:0070062 (located in) extracellular exosome
GO:0072563 (located in) endothelial microparticle
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)