Click here to access PB0209 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0209 P11142 Heat shock cognate 71 kDa protein HSPA8 HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71, heat shock protein family A (Hsp70) member 8 Homo_sapiens Interacts with VGF-derived peptide TLQP-21 (PubMed:28934328).

DomainsGene Ontology
PF00012 (HSP70)
GO:0000166 (enables) nucleotide binding
GO:0001664 (enables) G protein-coupled receptor binding
GO:0001786 (enables) phosphatidylserine binding
GO:0003723 (enables) RNA binding
GO:0005515 (enables) protein binding
GO:0005524 (enables) ATP binding
GO:0016787 (enables) hydrolase activity
GO:0016887 (enables) ATP hydrolysis activity
GO:0019899 (enables) enzyme binding
GO:0023026 (enables) MHC class II protein complex binding
GO:0030674 (enables) protein-macromolecule adaptor activity
GO:0031072 (enables) heat shock protein binding
GO:0031625 (enables) ubiquitin protein ligase binding
GO:0044183 (enables) protein folding chaperone
GO:0045296 (enables) cadherin binding
GO:0051082 (enables) unfolded protein binding
GO:0051087 (enables) chaperone binding
GO:0051787 (enables) misfolded protein binding
GO:0055131 (enables) C3HC4-type RING finger domain binding
GO:0140545 (enables) ATP-dependent protein disaggregase activity
GO:0140597 (enables) protein carrier chaperone
GO:0140662 (enables) ATP-dependent protein folding chaperone
GO:1990833 (enables) clathrin-uncoating ATPase activity
GO:0000398 (involved in) mRNA splicing, via spliceosome
GO:0006397 (involved in) mRNA processing
GO:0006457 (involved in) protein folding
GO:0006986 (involved in) response to unfolded protein
GO:0008380 (involved in) RNA splicing
GO:0009267 (involved in) cellular response to starvation
GO:0016192 (involved in) vesicle-mediated transport
GO:0031647 (involved in) regulation of protein stability
GO:0034620 (involved in) cellular response to unfolded protein
GO:0042026 (involved in) protein refolding
GO:0043254 (involved in) regulation of protein-containing complex assembly
GO:0044788 (involved in) modulation by host of viral process
GO:0044829 (involved in) positive regulation by host of viral genome replication
GO:0045892 (involved in) negative regulation of DNA-templated transcription
GO:0046034 (involved in) ATP metabolic process
GO:0048026 (involved in) positive regulation of mRNA splicing, via spliceosome
GO:0051085 (involved in) chaperone cofactor-dependent protein refolding
GO:0051726 (involved in) regulation of cell cycle
GO:0061024 (involved in) membrane organization
GO:0061077 (involved in) chaperone-mediated protein folding
GO:0061635 (involved in) regulation of protein complex stability
GO:0061684 (involved in) chaperone-mediated autophagy
GO:0061738 (involved in) late endosomal microautophagy
GO:0061740 (involved in) protein targeting to lysosome involved in chaperone-mediated autophagy
GO:0071383 (involved in) cellular response to steroid hormone stimulus
GO:0072318 (involved in) clathrin coat disassembly
GO:0099175 (involved in) regulation of postsynapse organization
GO:1902904 (involved in) negative regulation of supramolecular fiber organization
GO:1904589 (involved in) regulation of protein import
GO:1904764 (involved in) chaperone-mediated autophagy translocation complex disassembly
GO:1990832 (involved in) slow axonal transport
GO:0005764 (is active in) lysosome
GO:0005776 (is active in) autophagosome
GO:0030425 (is active in) dendrite
GO:0043195 (is active in) terminal bouton
GO:0099523 (is active in) presynaptic cytosol
GO:0099524 (is active in) postsynaptic cytosol
GO:0000974 (located in) Prp19 complex
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005634 (located in) nucleus
GO:0005654 (located in) nucleoplasm
GO:0005681 (located in) spliceosomal complex
GO:0005730 (located in) nucleolus
GO:0005737 (located in) cytoplasm
GO:0005765 (located in) lysosomal membrane
GO:0005770 (located in) late endosome
GO:0005829 (located in) cytosol
GO:0005886 (located in) plasma membrane
GO:0005925 (located in) focal adhesion
GO:0016020 (located in) membrane
GO:0034774 (located in) secretory granule lumen
GO:0042470 (located in) melanosome
GO:0043202 (located in) lysosomal lumen
GO:0048471 (located in) perinuclear region of cytoplasm
GO:0061202 (located in) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle
GO:0098575 (located in) lumenal side of lysosomal membrane
GO:0098684 (located in) photoreceptor ribbon synapse
GO:0098690 (located in) glycinergic synapse
GO:0098793 (located in) presynapse
GO:0098978 (located in) glutamatergic synapse
GO:0099634 (located in) postsynaptic specialization membrane
GO:1904813 (located in) ficolin-1-rich granule lumen
GO:0101031 (part of) chaperone complex
GO:1990904 (part of) ribonucleoprotein complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)