Click here to access PB0207 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0207 Q15165 Serum paraoxonase/arylesterase 2 PON2 paraoxonase 2 Homo_sapiens Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.

DomainsGene Ontology
PF01731 (Arylesterase)
GO:0004064 (enables) arylesterase activity
GO:0016787 (enables) hydrolase activity
GO:0042802 (enables) identical protein binding
GO:0046872 (enables) metal ion binding
GO:0102007 (enables) acyl-L-homoserine-lactone lactonohydrolase activity
GO:0006979 (involved in) response to oxidative stress
GO:0009636 (involved in) response to toxic substance
GO:0019439 (involved in) aromatic compound catabolic process
GO:0005576 (located in) extracellular region
GO:0005634 (located in) nucleus
GO:0005739 (located in) mitochondrion
GO:0005764 (located in) lysosome
GO:0005886 (located in) plasma membrane
GO:0016020 (located in) membrane
GO:0043231 (located in) intracellular membrane-bounded organelle

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)