Click here to access PB0204 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0204 P08253 72 kDa type IV collagenase MMP2 CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1, matrix metallopeptidase 2 Homo_sapiens Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

DomainsGene Ontology
PF00040 (3_fn2)
PF00045 (4_Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)
GO:0001968 (enables) fibronectin binding
GO:0004175 (enables) endopeptidase activity
GO:0004222 (enables) metalloendopeptidase activity
GO:0004252 (enables) serine-type endopeptidase activity
GO:0005515 (enables) protein binding
GO:0008233 (enables) peptidase activity
GO:0008237 (enables) metallopeptidase activity
GO:0008270 (enables) zinc ion binding
GO:0016787 (enables) hydrolase activity
GO:0046872 (enables) metal ion binding
GO:0001525 (involved in) angiogenesis
GO:0001541 (involved in) ovarian follicle development
GO:0001542 (involved in) ovulation from ovarian follicle
GO:0001553 (involved in) luteinization
GO:0001666 (involved in) response to hypoxia
GO:0001955 (involved in) blood vessel maturation
GO:0001957 (involved in) intramembranous ossification
GO:0006508 (involved in) proteolysis
GO:0006979 (involved in) response to oxidative stress
GO:0007162 (involved in) negative regulation of cell adhesion
GO:0007507 (involved in) heart development
GO:0007565 (involved in) female pregnancy
GO:0007566 (involved in) embryo implantation
GO:0007567 (involved in) parturition
GO:0007568 (involved in) aging
GO:0009314 (involved in) response to radiation
GO:0009410 (involved in) response to xenobiotic stimulus
GO:0009612 (involved in) response to mechanical stimulus
GO:0014012 (involved in) peripheral nervous system axon regeneration
GO:0014823 (involved in) response to activity
GO:0016477 (involved in) cell migration
GO:0022617 (involved in) extracellular matrix disassembly
GO:0030163 (involved in) protein catabolic process
GO:0030198 (involved in) extracellular matrix organization
GO:0030335 (involved in) positive regulation of cell migration
GO:0030574 (involved in) collagen catabolic process
GO:0032502 (involved in) developmental process
GO:0032526 (involved in) response to retinoic acid
GO:0034097 (involved in) response to cytokine
GO:0034614 (involved in) cellular response to reactive oxygen species
GO:0035094 (involved in) response to nicotine
GO:0035987 (involved in) endodermal cell differentiation
GO:0042542 (involved in) response to hydrogen peroxide
GO:0043065 (involved in) positive regulation of apoptotic process
GO:0043627 (involved in) response to estrogen
GO:0045906 (involved in) negative regulation of vasoconstriction
GO:0048013 (involved in) ephrin receptor signaling pathway
GO:0048661 (involved in) positive regulation of smooth muscle cell proliferation
GO:0048705 (involved in) skeletal system morphogenesis
GO:0048771 (involved in) tissue remodeling
GO:0050896 (involved in) response to stimulus
GO:0051602 (involved in) response to electrical stimulus
GO:0055093 (involved in) response to hyperoxia
GO:0060325 (involved in) face morphogenesis
GO:0060346 (involved in) bone trabecula formation
GO:0060740 (involved in) prostate gland epithelium morphogenesis
GO:0071230 (involved in) cellular response to amino acid stimulus
GO:0071345 (involved in) cellular response to cytokine stimulus
GO:0071347 (involved in) cellular response to interleukin-1
GO:0071392 (involved in) cellular response to estradiol stimulus
GO:0071492 (involved in) cellular response to UV-A
GO:0071498 (involved in) cellular response to fluid shear stress
GO:1904645 (involved in) response to amyloid-beta
GO:1904707 (involved in) positive regulation of vascular associated smooth muscle cell proliferation
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005634 (located in) nucleus
GO:0005737 (located in) cytoplasm
GO:0005739 (located in) mitochondrion
GO:0005886 (located in) plasma membrane
GO:0016020 (located in) membrane
GO:0030017 (located in) sarcomere
GO:0031012 (located in) extracellular matrix
GO:0062023 (located in) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)