Click here to access PB0202 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0202 Q96CG8 Collagen triple helix repeat-containing protein 1 CTHRC1 Homo_sapiens May act as a negative regulator of collagen matrix deposition.

DomainsGene Ontology
GO:0005109 (enables) frizzled binding
GO:0005201 (enables) extracellular matrix structural constituent
GO:0017147 (enables) Wnt-protein binding
GO:0001649 (involved in) osteoblast differentiation
GO:0016477 (involved in) cell migration
GO:0032092 (involved in) positive regulation of protein binding
GO:0033687 (involved in) osteoblast proliferation
GO:0033690 (involved in) positive regulation of osteoblast proliferation
GO:0043932 (involved in) ossification involved in bone remodeling
GO:0045669 (involved in) positive regulation of osteoblast differentiation
GO:0060071 (involved in) Wnt signaling pathway, planar cell polarity pathway
GO:0060122 (involved in) inner ear receptor cell stereocilium organization
GO:0090090 (involved in) negative regulation of canonical Wnt signaling pathway
GO:0090103 (involved in) cochlea morphogenesis
GO:0090177 (involved in) establishment of planar polarity involved in neural tube closure
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0016528 (located in) sarcoplasm
GO:0031012 (located in) extracellular matrix
GO:0005581 (part of) collagen trimer
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)