Click here to access PB0201 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0201 P10600 Transforming growth factor beta-3 proprotein TGFB3 ARVD, ARVD1, LDS5, RNHF, TGF-beta3 Homo_sapiens Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.

DomainsGene Ontology
PF00019 (TGF_beta)
PF00688 (TGFb_propeptide)
GO:0005114 (enables) type II transforming growth factor beta receptor binding
GO:0005125 (enables) cytokine activity
GO:0005160 (enables) transforming growth factor beta receptor binding
GO:0005515 (enables) protein binding
GO:0008083 (enables) growth factor activity
GO:0034713 (enables) type I transforming growth factor beta receptor binding
GO:0034714 (enables) type III transforming growth factor beta receptor binding
GO:0042802 (enables) identical protein binding
GO:0044877 (enables) protein-containing complex binding
GO:0050431 (enables) transforming growth factor beta binding
GO:0001666 (involved in) response to hypoxia
GO:0001701 (involved in) in utero embryonic development
GO:0007179 (involved in) transforming growth factor beta receptor signaling pathway
GO:0007435 (involved in) salivary gland morphogenesis
GO:0007565 (involved in) female pregnancy
GO:0007568 (involved in) aging
GO:0008284 (involved in) positive regulation of cell population proliferation
GO:0008285 (involved in) negative regulation of cell population proliferation
GO:0010718 (involved in) positive regulation of epithelial to mesenchymal transition
GO:0010862 (involved in) positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030501 (involved in) positive regulation of bone mineralization
GO:0030509 (involved in) BMP signaling pathway
GO:0030512 (involved in) negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030879 (involved in) mammary gland development
GO:0032570 (involved in) response to progesterone
GO:0032967 (involved in) positive regulation of collagen biosynthetic process
GO:0034616 (involved in) response to laminar fluid shear stress
GO:0042060 (involved in) wound healing
GO:0042476 (involved in) odontogenesis
GO:0042704 (involved in) uterine wall breakdown
GO:0043065 (involved in) positive regulation of apoptotic process
GO:0043410 (involved in) positive regulation of MAPK cascade
GO:0043524 (involved in) negative regulation of neuron apoptotic process
GO:0043627 (involved in) response to estrogen
GO:0043932 (involved in) ossification involved in bone remodeling
GO:0045216 (involved in) cell-cell junction organization
GO:0045893 (involved in) positive regulation of transcription, DNA-templated
GO:0045944 (involved in) positive regulation of transcription by RNA polymerase II
GO:0048286 (involved in) lung alveolus development
GO:0048565 (involved in) digestive tract development
GO:0048702 (involved in) embryonic neurocranium morphogenesis
GO:0048839 (involved in) inner ear development
GO:0050714 (involved in) positive regulation of protein secretion
GO:0051491 (involved in) positive regulation of filopodium assembly
GO:0051496 (involved in) positive regulation of stress fiber assembly
GO:0051781 (involved in) positive regulation of cell division
GO:0060325 (involved in) face morphogenesis
GO:0060364 (involved in) frontal suture morphogenesis
GO:0060391 (involved in) positive regulation of SMAD protein signal transduction
GO:0060395 (involved in) SMAD protein signal transduction
GO:0062009 (involved in) secondary palate development
GO:0070483 (involved in) detection of hypoxia
GO:1904706 (involved in) negative regulation of vascular associated smooth muscle cell proliferation
GO:1905075 (involved in) positive regulation of tight junction disassembly
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0005634 (located in) nucleus
GO:0005737 (located in) cytoplasm
GO:0005886 (located in) plasma membrane
GO:0009986 (located in) cell surface
GO:0030141 (located in) secretory granule
GO:0030315 (located in) T-tubule
GO:0031093 (located in) platelet alpha granule lumen
GO:0043025 (located in) neuronal cell body
GO:0043231 (located in) intracellular membrane-bounded organelle
GO:0062023 (located in) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)