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PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0200 P10909 Clusterin CLU Homo_sapiens Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed:21567405).

DomainsGene Ontology
PF01093 (Clusterin)
GO:0005856 (colocalizes with) cytoskeleton
GO:0071944 (colocalizes with) cell periphery
GO:0001540 (enables) amyloid-beta binding
GO:0005102 (enables) signaling receptor binding
GO:0005515 (enables) protein binding
GO:0031625 (enables) ubiquitin protein ligase binding
GO:0044877 (enables) protein-containing complex binding
GO:0048156 (enables) tau protein binding
GO:0050750 (enables) low-density lipoprotein particle receptor binding
GO:0051082 (enables) unfolded protein binding
GO:0051087 (enables) chaperone binding
GO:0051787 (enables) misfolded protein binding
GO:0140597 (enables) protein carrier chaperone
GO:0000902 (involved in) cell morphogenesis
GO:0001774 (involved in) microglial cell activation
GO:0001836 (involved in) release of cytochrome c from mitochondria
GO:0002376 (involved in) immune system process
GO:0002434 (involved in) immune complex clearance
GO:0006629 (involved in) lipid metabolic process
GO:0006915 (involved in) apoptotic process
GO:0006956 (involved in) complement activation
GO:0006958 (involved in) complement activation, classical pathway
GO:0009615 (involved in) response to virus
GO:0010628 (involved in) positive regulation of gene expression
GO:0017038 (involved in) protein import
GO:0031333 (involved in) negative regulation of protein-containing complex assembly
GO:0031334 (involved in) positive regulation of protein-containing complex assembly
GO:0032286 (involved in) central nervous system myelin maintenance
GO:0032436 (involved in) positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032760 (involved in) positive regulation of tumor necrosis factor production
GO:0042127 (involved in) regulation of cell population proliferation
GO:0042981 (involved in) regulation of apoptotic process
GO:0043065 (involved in) positive regulation of apoptotic process
GO:0043691 (involved in) reverse cholesterol transport
GO:0045087 (involved in) innate immune response
GO:0045429 (involved in) positive regulation of nitric oxide biosynthetic process
GO:0048260 (involved in) positive regulation of receptor-mediated endocytosis
GO:0050821 (involved in) protein stabilization
GO:0051092 (involved in) positive regulation of NF-kappaB transcription factor activity
GO:0051131 (involved in) chaperone-mediated protein complex assembly
GO:0051788 (involved in) response to misfolded protein
GO:0060548 (involved in) negative regulation of cell death
GO:0061077 (involved in) chaperone-mediated protein folding
GO:0061518 (involved in) microglial cell proliferation
GO:0061740 (involved in) protein targeting to lysosome involved in chaperone-mediated autophagy
GO:0090201 (involved in) negative regulation of release of cytochrome c from mitochondria
GO:1900221 (involved in) regulation of amyloid-beta clearance
GO:1901214 (involved in) regulation of neuron death
GO:1901216 (involved in) positive regulation of neuron death
GO:1902004 (involved in) positive regulation of amyloid-beta formation
GO:1902230 (involved in) negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902430 (involved in) negative regulation of amyloid-beta formation
GO:1902847 (involved in) regulation of neuronal signal transduction
GO:1902949 (involved in) positive regulation of tau-protein kinase activity
GO:1902998 (involved in) positive regulation of neurofibrillary tangle assembly
GO:1903573 (involved in) negative regulation of response to endoplasmic reticulum stress
GO:1905892 (involved in) negative regulation of cellular response to thapsigargin
GO:1905895 (involved in) negative regulation of cellular response to tunicamycin
GO:1905907 (involved in) negative regulation of amyloid fibril formation
GO:1905908 (involved in) positive regulation of amyloid fibril formation
GO:2000060 (involved in) positive regulation of ubiquitin-dependent protein catabolic process
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005634 (located in) nucleus
GO:0005737 (located in) cytoplasm
GO:0005739 (located in) mitochondrion
GO:0005743 (located in) mitochondrial inner membrane
GO:0005783 (located in) endoplasmic reticulum
GO:0005794 (located in) Golgi apparatus
GO:0005829 (located in) cytosol
GO:0009986 (located in) cell surface
GO:0016020 (located in) membrane
GO:0031093 (located in) platelet alpha granule lumen
GO:0031410 (located in) cytoplasmic vesicle
GO:0031966 (located in) mitochondrial membrane
GO:0042583 (located in) chromaffin granule
GO:0043231 (located in) intracellular membrane-bounded organelle
GO:0045202 (located in) synapse
GO:0048471 (located in) perinuclear region of cytoplasm
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle
GO:0097418 (located in) neurofibrillary tangle
GO:0097440 (located in) apical dendrite
GO:0099020 (located in) perinuclear endoplasmic reticulum lumen
GO:0032991 (part of) protein-containing complex
GO:0034366 (part of) spherical high-density lipoprotein particle

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)