Click here to access PB0196 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0196 P29279 CCN family member 2 CCN2 CTGF, HCS24, IGFBP8, NOV2, cellular communication network factor 2 Homo_sapiens Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

DomainsGene Ontology
PF00007 (Cys_knot)
PF00093 (VWC)
PF00219 (IGFBP)
PF19035 (TSP1_CCN)
GO:0062023 (colocalizes with) collagen-containing extracellular matrix
GO:0001968 (enables) fibronectin binding
GO:0005178 (enables) integrin binding
GO:0005515 (enables) protein binding
GO:0005520 (enables) insulin-like growth factor binding
GO:0008022 (enables) protein C-terminus binding
GO:0008083 (enables) growth factor activity
GO:0008201 (enables) heparin binding
GO:0001502 (involved in) cartilage condensation
GO:0001503 (involved in) ossification
GO:0001525 (involved in) angiogenesis
GO:0001894 (involved in) tissue homeostasis
GO:0001934 (involved in) positive regulation of protein phosphorylation
GO:0007155 (involved in) cell adhesion
GO:0007160 (involved in) cell-matrix adhesion
GO:0007165 (involved in) signal transduction
GO:0007229 (involved in) integrin-mediated signaling pathway
GO:0007568 (involved in) aging
GO:0008284 (involved in) positive regulation of cell population proliferation
GO:0008543 (involved in) fibroblast growth factor receptor signaling pathway
GO:0008544 (involved in) epidermis development
GO:0009611 (involved in) response to wounding
GO:0009749 (involved in) response to glucose
GO:0010628 (involved in) positive regulation of gene expression
GO:0010629 (involved in) negative regulation of gene expression
GO:0010942 (involved in) positive regulation of cell death
GO:0014070 (involved in) response to organic cyclic compound
GO:0016477 (involved in) cell migration
GO:0030154 (involved in) cell differentiation
GO:0030324 (involved in) lung development
GO:0032330 (involved in) regulation of chondrocyte differentiation
GO:0032355 (involved in) response to estradiol
GO:0032967 (involved in) positive regulation of collagen biosynthetic process
GO:0034059 (involved in) response to anoxia
GO:0035556 (involved in) intracellular signal transduction
GO:0035988 (involved in) chondrocyte proliferation
GO:0043200 (involved in) response to amino acid
GO:0043280 (involved in) positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043434 (involved in) response to peptide hormone
GO:0045597 (involved in) positive regulation of cell differentiation
GO:0046330 (involved in) positive regulation of JNK cascade
GO:0050867 (involved in) positive regulation of cell activation
GO:0051385 (involved in) response to mineralocorticoid
GO:0051496 (involved in) positive regulation of stress fiber assembly
GO:0060401 (involved in) cytosolic calcium ion transport
GO:0060452 (involved in) positive regulation of cardiac muscle contraction
GO:0060548 (involved in) negative regulation of cell death
GO:0061448 (involved in) connective tissue development
GO:0070278 (involved in) extracellular matrix constituent secretion
GO:0070318 (involved in) positive regulation of G0 to G1 transition
GO:0070374 (involved in) positive regulation of ERK1 and ERK2 cascade
GO:0070542 (involved in) response to fatty acid
GO:0071897 (involved in) DNA biosynthetic process
GO:0072593 (involved in) reactive oxygen species metabolic process
GO:0031012 (is active in) extracellular matrix
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005801 (located in) cis-Golgi network
GO:0005829 (located in) cytosol
GO:0005886 (located in) plasma membrane
GO:0005938 (located in) cell cortex
GO:0048471 (located in) perinuclear region of cytoplasm

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)