PB0196

DATABASE

Click here to access PB0196 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0196	P29279	CCN family member 2	CCN2	CTGF, HCS24, IGFBP8, NOV2, cellular communication network factor 2	Homo_sapiens	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Domains

Gene Ontology

PF00007 (Cys_knot) PF00093 (VWC) PF00219 (IGFBP) PF19035 (TSP1_CCN)

GO:0062023 (colocalizes with) collagen-containing extracellular matrix GO:0001968 (enables) fibronectin binding GO:0005178 (enables) integrin binding GO:0005515 (enables) protein binding GO:0005520 (enables) insulin-like growth factor binding GO:0008022 (enables) protein C-terminus binding GO:0008083 (enables) growth factor activity GO:0008201 (enables) heparin binding GO:0001502 (involved in) cartilage condensation GO:0001503 (involved in) ossification GO:0001525 (involved in) angiogenesis GO:0001894 (involved in) tissue homeostasis GO:0001934 (involved in) positive regulation of protein phosphorylation GO:0007155 (involved in) cell adhesion GO:0007160 (involved in) cell-matrix adhesion GO:0007165 (involved in) signal transduction GO:0007229 (involved in) integrin-mediated signaling pathway GO:0007568 (involved in) aging GO:0008284 (involved in) positive regulation of cell population proliferation GO:0008543 (involved in) fibroblast growth factor receptor signaling pathway GO:0008544 (involved in) epidermis development GO:0009611 (involved in) response to wounding GO:0009749 (involved in) response to glucose GO:0010628 (involved in) positive regulation of gene expression GO:0010629 (involved in) negative regulation of gene expression GO:0010942 (involved in) positive regulation of cell death GO:0014070 (involved in) response to organic cyclic compound GO:0016477 (involved in) cell migration GO:0030154 (involved in) cell differentiation GO:0030324 (involved in) lung development GO:0032330 (involved in) regulation of chondrocyte differentiation GO:0032355 (involved in) response to estradiol GO:0032967 (involved in) positive regulation of collagen biosynthetic process GO:0034059 (involved in) response to anoxia GO:0035556 (involved in) intracellular signal transduction GO:0035988 (involved in) chondrocyte proliferation GO:0043200 (involved in) response to amino acid GO:0043280 (involved in) positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043434 (involved in) response to peptide hormone GO:0045597 (involved in) positive regulation of cell differentiation GO:0046330 (involved in) positive regulation of JNK cascade GO:0050867 (involved in) positive regulation of cell activation GO:0051385 (involved in) response to mineralocorticoid GO:0051496 (involved in) positive regulation of stress fiber assembly GO:0060401 (involved in) cytosolic calcium ion transport GO:0060452 (involved in) positive regulation of cardiac muscle contraction GO:0060548 (involved in) negative regulation of cell death GO:0061448 (involved in) connective tissue development GO:0070278 (involved in) extracellular matrix constituent secretion GO:0070318 (involved in) positive regulation of G0 to G1 transition GO:0070374 (involved in) positive regulation of ERK1 and ERK2 cascade GO:0070542 (involved in) response to fatty acid GO:0071897 (involved in) DNA biosynthetic process GO:0072593 (involved in) reactive oxygen species metabolic process GO:0031012 (is active in) extracellular matrix GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005801 (located in) cis-Golgi network GO:0005829 (located in) cytosol GO:0005886 (located in) plasma membrane GO:0005938 (located in) cell cortex GO:0048471 (located in) perinuclear region of cytoplasm

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P29279|CCN2_HUMAN CCN family member 2 OS=Homo sapiens OX=9606 GN=CCN2 PE=1 SV=2 MTAASMGPVRVAFVVLLALCSRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVC AKQLGELCTERDPCDPHKGLFCHFGSPANRKIGVCTAKDGAPCIFGGTVYRSGESFQSSC KYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALA AYRLEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVR PCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTT LPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >sp|P29279-2|CCN2_HUMAN Isoform 2 of CCN family member 2 OS=Homo sapiens OX=9606 GN=CCN2 MTAASMGPVRVAFVVLLALCSRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVC AKQLGELCTERDPCDPHKGLFCHFGSPANRKIGVCTAKDGAPCIFGGTVYRSGESFQSSC KYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDCLVQTTEWS ACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIK FELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHY NCPGDNDIFESLYYRKMYGDMA >tr|Q5RI33|Q5RI33_DANRE Cellular communication network factor 2a OS=Danio rerio OX=7955 GN=ccn2a PE=2 SV=1 MFSGMTQSVIALLFLTFLRWAVAQECSGQCHCPEVPPQCSPGVSLVLDTCGCCRVCAKQL GELCTERDVCDPHKGLYCDYGSPSNRRIGVCTARDGATCVFGGMVYRSGESFQSSCKYQC TCLDGAVGCVPLCGMDIRLPSPDCPMPRRVKVPGKCCEEWVCDSPRQNTFVGSALAAYRE EETYGPDPSMMRENCLVQTTEWSACSKTCGLGISTRVTNDNRECRLEKQSRLCMVRPCES HLEEKIRKGKKCIRTPRVSKPMKFEISGCTTTKSYRPKFCGVCTDGRCCTPHRTATLPME FKCPDGQVMKKQMMFIKTCACHYNCPGENDIFESMYYKKMVGDMA
Selected proteins from model organisms >sp|P29279|CCN2_HUMAN CCN family member 2 OS=Homo sapiens OX=9606 GN=CCN2 PE=1 SV=2 MTAASMGPVRVAFVVLLALCSRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVC AKQLGELCTERDPCDPHKGLFCHFGSPANRKIGVCTAKDGAPCIFGGTVYRSGESFQSSC KYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALA AYRLEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVR PCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTT LPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >sp|P29279-2|CCN2_HUMAN Isoform 2 of CCN family member 2 OS=Homo sapiens OX=9606 GN=CCN2 MTAASMGPVRVAFVVLLALCSRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVC AKQLGELCTERDPCDPHKGLFCHFGSPANRKIGVCTAKDGAPCIFGGTVYRSGESFQSSC KYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDCLVQTTEWS ACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIK FELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHY NCPGDNDIFESLYYRKMYGDMA >tr|Q5RI33|Q5RI33_DANRE Cellular communication network factor 2a OS=Danio rerio OX=7955 GN=ccn2a PE=2 SV=1 MFSGMTQSVIALLFLTFLRWAVAQECSGQCHCPEVPPQCSPGVSLVLDTCGCCRVCAKQL GELCTERDVCDPHKGLYCDYGSPSNRRIGVCTARDGATCVFGGMVYRSGESFQSSCKYQC TCLDGAVGCVPLCGMDIRLPSPDCPMPRRVKVPGKCCEEWVCDSPRQNTFVGSALAAYRE EETYGPDPSMMRENCLVQTTEWSACSKTCGLGISTRVTNDNRECRLEKQSRLCMVRPCES HLEEKIRKGKKCIRTPRVSKPMKFEISGCTTTKSYRPKFCGVCTDGRCCTPHRTATLPME FKCPDGQVMKKQMMFIKTCACHYNCPGENDIFESMYYKKMVGDMA >NP_034347.2 CCN family member 2 precursor [Mus musculus] MLASVAGPISLALVLLALCTRPAMGQDCSAQCQCAAEAAPHCPAGVSLVLDGCGCCRVCAKQLGELCTER DPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCVFGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDV RLPSPDCPFPRRVKLPGKCCEEWVCDEPKDRTAVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSK TCGMGISTRVTNDNTFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKIAKPVKFELSGCTSVKTYRA KFCGVCTDGRCCTPHRTTTLPVEFKCPDGEIMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >NP_071602.1 CCN family member 2 precursor [Rattus norvegicus] MLASVAGPVSLALVLLLCTRPATGQDCSAQCQCAAEAAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERD PCDPHKGLFCDFGSPANRKIGVCTAKDGAPCVFGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVR LPSPDCPFPRRVKLPGKCCEEWVCDEPKDRTVVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSKT CGMGISTRVTNDNTFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKIAKPVKFELSGCTSVKTYRAK FCGVCTDGRCCTPHRTTTLPVEFKCPDGEIMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >NP_776455.1 CCN family member 2 precursor [Bos taurus] MSATGLGPVRCAFVLLLALCSRPASSQDCCSAPCQCPAGPAPRCPAGVSLVLDGCGCCVCAKQLSELCTE RDPCDPHKGLFCDFGSPTNRKIGVCTAKDGAPYIFGGTVYQSGESFQSSCKYQCTCLDGSVGCVPLCSVD VRLPSPDCPFPRRVKLPGKCCEEWVSRDEKEHTVVGPALAAYRLEDTFGPDPTMIRANCQVQTTEWSAYS KTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFQLSGCTSMKTYR AKFFGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >NP_989605.1 CCN family member 2 precursor [Gallus gallus] MSPASLAVALLLALLGPEVRGQECSGQCQCGSGPGPSCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCD HHKGLFCDFGSPANRRIGVCTARDGAPCVFSGMVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPS PDCPYPRRVKLPGKCCEEWVCDEAKEQTAVGPALAAYRLEDTYGPDPTMMRANCLVQTTEWSACSKTCGM GISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCG VCTDGRCCTPHRTATLPVEFKCPDGEIMKRKMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >NP_001267240.1 CCN family member 2 precursor [Pan troglodytes] MTAASVGPVRVAFVLLLALCSRPAVGQNCSGPCRCSDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTE RDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMD VRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACS KTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYR AKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMTFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >XP_003638817.1 CCN family member 2 [Canis lupus familiaris] MSAAGLGPVRGAFLLLLALCGRPAAGQDCGGQCPCAAAPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTE RDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCVFGGTVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMD VRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDHTVVGPALAAYRLEDTFGPDPTMIRANCLVQTTEWSACS KTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKIAKPVKFELSGCTSVKTYR AKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >XP_017200867.1 PREDICTED: connective tissue growth factor [Oryctolagus cuniculus] MAAAVGPLRFAFVLLLALCSRADRPFLPAAGPPAQDCGGQCQCAAAPAPRCPAGVSLVLDGCGCCRVCAK QLGELCTERDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCVFGGTVYRSGESFQSSCKYQCTCLDGAVG CVPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDHTVVGPALAAYRLEDTFGPDPTMMRANCLVQ TTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPVKFELSG CTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGELMKKSMMFIKTCACHYNCPGDNDIFESLYYR KMYGDMA >NP_998998.2 CCN family member 2 precursor [Sus scrofa] MSATGLSPVRCAFVLLLALCSRPASGQDCSGQCQCAAGKAPRCPAGVSLVLDGCGCCRVCAKQLGELCTE RDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCVFGGTVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMD VRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDHTVVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACS KTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPVKFELSGCTSVKTYR AKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >NP_001158186.1 CCN family member 2 precursor [Ovis aries] MSATGLSPVRCAFVLLLALCSRPASGQDCSAPCQCPAGPAPRCPAGVSLVLDGCGCCRVCAKQLSELCTE RDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCVFGGTVYRSGESFQSSCKYQCTCLDGSVGCVPLCSVD IRLPSPDCPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDTFGPDPTMIRANCLVQTTEWSACS KTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYR AKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >XP_002817410.1 connective tissue growth factor [Pongo abelii] MTAASVGPVRVAFVLLLALCSRPAVGQNCSGPCRCPAEPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTE RDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCIFGGTVYRNGESFQSSCKYQCTCLDGAVGCMPLCSMD VRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMIRANCLVQTTEWSACS KTCGMGISTRVTNDNTSCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYR AKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >XP_003204260.2 CCN family member 2 [Meleagris gallopavo] MKQLQDPRLLSLILLAPLPELGWHKQLCSQTVNPIQELSQLKTLNIFSSWLFFTWFSSLTYLTLQQHKVN TSIERGLLQQEKQGGPLGKQAAGRGSRRPGRCVTARLLPSLAARDGAPCVFSGMVYRSGESFQSSCKYQC TCLDGAVGCVPLCSMDVRLPSPDCPYPRRVKLPGKCCEEWVCDEAKEQTAVGPALAAYRLEDTYSPDPTM MRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISK PIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTATLPVEFKCPDGEIMKRKMMFIKTCACHYNCPGDND IFESLYYRKMYGDMA >XP_034818756.1 CCN family member 2 [Pan paniscus] MTAASVGPVRVAFVLLLALCSRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTE RDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMD VRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACS KTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYR AKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >XP_023110145.1 CCN family member 2 [Felis catus] MSAAGLGPVRCAFVLLFALCGRPAAGQDCGGPCQCAAAPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTE RDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCVFGGTVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMD VRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDHTVVGPALAAYRLEDTFGPDPTMIRANCLVQTTEWSACS KTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPVKFELSGCTSVKTYR AKFCGVCTDGRCCTPHRTTTLPVEFKCPDGELMKKSMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >XP_018885110.2 CCN family member 2 [Gorilla gorilla gorilla] MTAASVGPVRVAFVLLLALCSRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTE RDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMD VRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMIRANCLVQTTEWSACS KTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYR AKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >XP_005509444.1 connective tissue growth factor [Columba livia] MVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPYPRRVKLPGKCCEEWVCDEAKEQTAVGP ALAAYRLEDTYGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLE ENIKKGKKCIRTPKISKPVKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTATLPVEFKCPDGETMKRKM MFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >XP_017908714.1 PREDICTED: connective tissue growth factor [Capra hircus] MSATGLSPVRCAFVLLLALCSRPASGQDCSAPCQCPAGPVPRCPAGVSLVLDGCGCCRVCAKQLSELCTE RDPCDRHKGLFCDFGSPANRKIGVCTAKDGAPCVFGGTVYRSGESFQSSCKYQCTCLDGSVGCVPLCSVD IRLPSPDCPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDTFGPDPTMIRANCLVQTTEWSACS KTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYR AKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >XP_006030850.1 connective tissue growth factor [Alligator sinensis] MQDLTPELDALMSFLPAFVSYDSSIPQQPPPGLTQPSPKSSRCLGAQLIPSRFLLAARDGAPCVFGGMVY RSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPYPRRVKLPGKCCEEWVCDEPKERTAVGPALA AYRLEDTYGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEVDLEENI KKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTATLPVEFKCPDGEVMKRRMMFI KTCACHYNCPGDNDIFESLYYRKMYGDMA >XP_006270595.1 PREDICTED: connective tissue growth factor [Alligator mississippiensis] MGPLRLALPLLLALLGRAAAQDCSGQCQCAAPPRCPAGVSLVPDGCGCCRVCAKQLGELCTERDPCDPHK GLFCDFGSPANRKIGVCTARDGAPCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDC PYPRRVKLPGKCCEEWVCDEPKEQTAVGPALAAYRLEDTYGPDPTMMRANCLVQTTEWSACSKTCGMGIS TRVTNDNAFCRLEKQSRLCMVRPCEVDLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCT DGRCCTPHRTATLPVEFKCPDGEVMKRRMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >XP_020738137.1 connective tissue growth factor [Odocoileus virginianus texanus] MMLDPCTPRFFPSTPSAKDGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGVDVRLPSPNCPF PRRVKLPGKCCEEWVCDEAKEHTVVGPALAAYRPEDTFGPDPTMLRANCLVQTTEWSACSKTCGMGISTR VTNDNALCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDG RCCTPHRTTTLPVDFKCPDGEVMKKSMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA >XP_040206376.1 CCN family member 2 [Rana temporaria] MSFGKVTAALLLTVLCWVTDAQDCSGECQCPQKIPECSPGVSLVQDGCGCCKVCAKQLGELCTEKDVCDP HKGLFCDFGSRINRKIGVCTAREGAPCVFGGMVYRSGESFQSSCKYQCTCLDGGVGCVPLCSMDVRLPSP DCPYPRRVKLPGKCCEEWVCDQPMEKTMVGPALPAFRMEETYGPDPSLMRANCLVQTTEWSACSKTCGMG ISTRVTNDNEHCRLEKQNRLCMVRPCEADLEENIKKGKKCIRTPKISKPVKFEFSGCTSVKTYRAKFCGV CTDGRCCTPHRTATLPVEFKCPDGEVMKKKMMFIKTCACHYNCPGDNDIFESMYYRKMYGDMA >KAB0380657.1 hypothetical protein FD755_008441 [Muntiacus reevesi] MSATGLGPVCCAFALLLALCSRPASGRDCSAPCQCPAGPEPRCPAGVSLVLDGCGCCRVCAKQLSELCTERDPCDPHKGL FCDFGSPANRKIGVCTAKDGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGMDVRLPSPNCPFPRRVKLPGKC CEEWVCDEPKEHTVVGPALAAYRPEDTFGPDPTMLRANCLVQTTEWSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVR PCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVDFKCPDGEVMKKSMMFI KTCACHYNCPGDNDIFESLYYRKMYGDMA >XP_043313099.1 CCN family member 2 [Cervus canadensis] MSATGLGPVCCAFALLLALCSRPASGRDCSAPCQCPAGPEPRCPAGVSLVLDGCGCCRVCAKQLSELCTERDPCDPHKGL FCDFGSPANRKIGVCTAKDGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGVDVRLPSPSCPFPRRVKLPGKC CEEWVCDEPKEHTVVGPALAAYRPEDTFGPDPTMLRANCLVQTTEWSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVR PCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVDFKCPDGEVMKKSMMFI KTCACHYNCPGDNDIFESLYYRKMYGDMA >KAB0360259.1 hypothetical protein FD754_004415 [Muntiacus muntjak] MSATGLGPVCCALALLLALCSRPASGRDCSAPCQCPAGPEPRCPAGVSLVLDGCGCCRVCAKQLSELCTERDPCDPHKGL FCDFGSPANRKIGVCTAKDGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGMDVRLPSPNCPFPRRVKLPGKC CEEWVCDEPKEHTVVGPALAAYRPEDTFGPDPTMLRANCLVQTTEWSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVR PCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVDFKCPDGEVMKKSMMFI KTCACHYNCPGDNDIFESLYYRKMYGDMA >KAF4024571.1 hypothetical protein G4228_016524 [Cervus hanglu yarkandensis] MKETKTLKITKTTSPASGRDCSAPCQCPAGPEPRCPAGVSLVLDGCGCCRVCAKQLSELCTERDPCDPHKGLFCDFGSPA NRKIGVCTAKDGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGVDVRLPSPSCPFPRRVKLPGKCCEEWVCDE PKEHTVVGPALAAYRPEDTFGPDPTMLRANCLVQTTEWSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVRPCEADLEE NIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVDFKCPDGEVMKKSMMFIKTCACHYN CPGDNDIFESLYYRKMYGDMA >NP_001081697.1 connective tissue growth factor precursor [Xenopus laevis] MSAGKVTAVLLFALFCWVSDAQECNGECQCPNKVPVCDPGVSLVQDGCGCCKVCSKQLGELCTERDVCDPHKGLFCDFGS RVNRKIGVCTAREGAPCVFGGTVYRSGESFQSSCKYQCTCIDGGVGCVPLCSMDIRLPSPECPFPRRVKLPGKCCEEWVC DQPQERTLVGPALPAFRMEETYGPDPSLIRANCLVQTTEWSACSKTCGMGISTRVTNDNEHCRLEKQSRLCMVRPCEADL EENIKKGKKCIRTPKISKPVKFEFSGCTSVKTYRAKFCGVCTDGRCCTPHRTATLPVEFKCPDGEVMKKNMMFIKTCACH FNCPGDNDIFEAMYYRKMYGDMA >XP_030261392.1 CCN family member 2 [Sparus aurata] MSAGMKKMILLPFLCIMLSYMAAGQECSNQCSCPSTPPQCPPGVSLVLDGCGCCRVCAKQMGELCTERDLCDPHKGLYCD FGAPINRRIGVCTARDGATCVFGGMVYKSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPMPRRVKVPGKCCEE WECDSPYRHSFMGSALAAYREEETYGPDPSMMRENCLVQTTEWSACSKTCGLGISTRVTNDNRECRLEKQTRLCMVRPCE SQLEQSIRKGKKCIRTPRLSKPMKFEISGCTTTKSYRPKFCGVCLDGRCCTPHRTTTLPMEFKCPDGQVMKKHMMFIKSC ACHHNCPGENDIFESMYYKKMMGDMA >XP_004084039.1 connective tissue growth factor [Oryzias latipes] MFANKEKVIWLPLLCLIYSYAAAGQECSGQCSCPSAPPRCPPGVSLVLDGCGCCRVCAKQMGELCTDKDVCDPHKNLFCD IGAPISRRIGVCTAREGASCVFGGTVYKSGETFQSSCKYQCTCMDGAMGCVPLCSMDIRLPSPDCPMPRRVKVPGKCCEE WECDSPYKDTLLGPALSAFREEETYGPDPNMMRENCLVQTTEWSACSKTCGLGISTRVTNDNHECRLEKQTRLCMVRPCE SQMEQSIKKGKKCIRTPRVSKPMKFEISGCTTTKSYRPKFCGVCLDGRCCTPHRTTTLPMEFKCPDGQVMKKHMMFIKSC ACHYNCPGENDIFEAMYYKKMTGDTV >XP_015803465.1 PREDICTED: connective tissue growth factor [Nothobranchius furzeri] MFAGVKKMVILPVLCVMFSCMAAGQDCSGQCSCPSTPPQCPPGVSLVLDGCGCCRVCAKQMGELCTERDVCDPHKDLYCD FGAPINRRIGVCTAREGATCVFGGMVYKSGESFQSSCKYQCTCLDGAMGCVPLCSMDIRLPSPDCPMPRRVKVPGKCCEE WECDSSFTTSMGSVLAAYREEETYGPDPNMRRENCLVQTTEWSACSRTCGLGISTRVTNDNRECRLEKQTRLCMVRPCES QLEQSIRKGKKCIRTPRVSKPMKFEISGCTTTKSYRPKFCGVCLDGRCCTPHRTTTLPMEFKCPNGEVMKKHMMFIKSCA CHYNCPGENDIFESMYYKKMYGDMA >OWK01970.1 CTGF [Cervus elaphus hippelaphus] MMLDPCIPRFFSSSPSAKDGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGVDVRLPSPSCPFPRRVKLPGKC CEEWVCDEPKEHTVVGPALAAYRPEDTFGPDPTMLRANCLVQTTEWSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVR PCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVDFKCPDGEVMKKSMMFI KTCACHYNCPGDNDIFESLYYRKMYGDMA >XP_039253619.1 CCN family member 2-like [Styela clava] MSTFYYCLLVFVILSVTSIQTSMAKDCSKPCPKCPSVTKCAFGVSIVPDECGCCKTCAKQLYESCDASNPCDHHKNLYCS FGDVDDTAGVCVAKPGRSCFLNGKVYLNGESFSPSCKVHCTCIDSDFGCMPRCPVSAKIPPNCEHPRLVLKPGKCCEEWI CMKSSRKSVMPKINRQIKSNESRHGKHSPRPAVFNFAAARRQPEVSLAIRGECMVQTTQWSACSKSCGWGVSERVTNDNK ACKLMKETRLCQIRPCGEDYTARVKKGKKCIRSPKATKPVRYSFSGCKTKVYTPKYCGQCVDGRCCTPERTKTVTVTFHC DDGFSFKKRMMQIKSCSCHRKCGSSDNDIFNSYRQITKGDDKV >NP_730294.1 Ccn [Drosophila melanogaster] MLILLPLLGIFGNGFVAEVEANLSLGFKAIKLPRHPNPANCSVGNTTFAHGVTFKLDCKTQCVCENGRHACSTLCPNEQL PAPEDTISCRSPRLVEVPGHCCKMWLCENPTADVYATCHNSTTSGNWTACSRSCGLGTATRHTTTHAGCHQLSNLRLCEN RRCDKDDHEDNKWSRSRPLTHKRKQHRAHSHSHQRYHHHKEHEEPAHRIRKGHECRSIQRLGPARIRLGECVSRKLYRPK LCGRCHRGVKCCAPAVSTTIQVELLCPLNAVDPINYVQRRQANKKRQMKEPQDDEDDDDDDDGDDNVEPEPVLQSAQLWD TVALEPIDQEFLQSHQIQIENKFIAVEWILKCECSTKNCNAGSSNISSNSNSNDNMANTNKYGYYNYKNNNRGRNHETNG EPNEPTNNNAGNNKDNEEDVVDSGNNLDHNDVDNMSSEQQPDIIPYPPSVGESSWKAEKLRQQHHWQQNT >XP_030854983.1 kielin/chordin-like protein [Strongylocentrotus purpuratus] MALPSAVGEAERGNVRFEDSVQGCSSWPTMTWSMAESKMNLQVRSSTANSINLSWNSFLPIDGTSTQGHYVVYYTTTFSN HIQSWLGQIEAGNETHTSIRNLKDGTDYYFRVSYRIPGRGVHLEGHLSEVALHRTGTPAPLGGCEHDSRHYDEGMTIHQS CDSVCDCLLGSWICRPRGCPPKPDVRINPVNCREEPHPDDPECCTMIKCEEGSNDSIQPADCNDGGVLRVHGETYYHECD EVCFCDNGVSDCTRRCPDAGQMIPDLQTCPHPTLLEPPEGECCPHWSCPPPPNSCELNGNTYEDGEYFDVDCSMRCQCLG GSVRCVPRCPVSFAVSTVNCPNPTRVQLPGECCLQWECEQPAEQVCIHNGEFPRH
Mafft alignment of selected proteins >sp|P29279|CCN2_HUMAN CCN family member 2 OS=Homo sapiens OX=9606 GN=CCN2 PE=1 SV=2 MT------------------------------------------AASMGPVRVA-FVVLL ALCSR------------------------------------------------------- -------PAVG---------------------------QN-CSGPC-------------- ----------------------RCPDEPAPRCPAGV--SLVLDGC--------GCCRVCA KQLGEL-CTERDPCD----------PHKG------LFCHFGSPANRKIGVC--------- TAK-----DGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPD--- -CPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDT----FGPDPTM-------- -------IRANCLVQTTE--WSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSMKTYRAKFCGVCTDG-RCCTPHRTTTLPVEFKCPDGEV-----------MKK NMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >sp|P29279-2|CCN2_HUMAN Isoform 2 of CCN family member 2 OS=Homo sapiens OX=9606 GN=CCN2 MT------------------------------------------AASMGPVRVA-FVVLL ALCSR------------------------------------------------------- -------PAVG---------------------------QN-CSGPC-------------- ----------------------RCPDEPAPRCPAGV--SLVLDGC--------GCCRVCA KQLGEL-CTERDPCD----------PHKG------LFCHFGSPANRKIGVC--------- TAK-----DGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPD--- -CPFPRRVKLPGKCCEEWVCDEPKD----------------------------------- -----------CLVQTTE--WSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSMKTYRAKFCGVCTDG-RCCTPHRTTTLPVEFKCPDGEV-----------MKK NMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >tr|Q5RI33|Q5RI33_DANRE Cellular communication network factor 2a OS=Danio rerio OX=7955 GN=ccn2a PE=2 SV=1 ---------------------------------------------MFSGMTQSV-IALLF LTFLR------------------------------------------------------- -------WAVA---------------------------QE-CSGQC-------------- ----------------------HCPEV-PPQCSPGV--SLVLDTC--------GCCRVCA KQLGEL-CTERDVCD----------PHKG------LYCDYGSPSNRRIGVC--------- TAR-----DGATCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLCGMDIRLPSPD--- -CPMPRRVKVPGKCCEEWVCDSPRQNTFVGSALAAYREEET----YGPDPSM-------- -------MRENCLVQTTE--WSACSKTCGLGISTRVTNDNRECRLEKQSRLCMVRPCESH LEE--------------------------------------KIRKGKKCIRTPRVSKPMK FEISGCTTTKSYRPKFCGVCTDG-RCCTPHRTATLPMEFKCPDGQV-----------MKK QMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------ENDIFES--------------------MYYKKMV-GDMA---------- ------ >NP_034347.2 CCN family member 2 precursor [Mus musculus] ML------------------------------------------ASVAGPISLA-LVLL- ALCTR------------------------------------------------------- -------PAMG---------------------------QD-CSAQC-------------- ----------------------QCAAEAAPHCPAGV--SLVLDGC--------GCCRVCA KQLGEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCVFGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPD--- -CPFPRRVKLPGKCCEEWVCDEPKDRTAVGPALAAYRLEDT----FGPDPTM-------- -------MRANCLVQTTE--WSACSKTCGMGISTRVTNDNTFCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKIAKPVK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTTTLPVEFKCPDGEI-----------MKK NMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >NP_071602.1 CCN family member 2 precursor [Rattus norvegicus] ML------------------------------------------ASVAGPVSLA-LVLL- -LCTR------------------------------------------------------- -------PATG---------------------------QD-CSAQC-------------- ----------------------QCAAEAAPRCPAGV--SLVLDGC--------GCCRVCA KQLGEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCVFGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPD--- -CPFPRRVKLPGKCCEEWVCDEPKDRTVVGPALAAYRLEDT----FGPDPTM-------- -------MRANCLVQTTE--WSACSKTCGMGISTRVTNDNTFCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKIAKPVK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTTTLPVEFKCPDGEI-----------MKK NMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >NP_776455.1 CCN family member 2 precursor [Bos taurus] MS------------------------------------------ATGLGPVRCA-FVLLL ALCSR------------------------------------------------------- -------PASS---------------------------QDCCSAPC-------------- ----------------------QCPAGPAPRCPAGV--SLVLDGC--------GCC-VCA KQLSEL-CTERDPCD----------PHKG------LFCDFGSPTNRKIGVC--------- TAK-----DGAPYIFGGTVYQSGESFQSSCKYQCTCLDGSVGCVPLCSVDVRLPSPD--- -CPFPRRVKLPGKCCEEWVSRDEKEHTVVGPALAAYRLEDT----FGPDPTM-------- -------IRANCQVQTTE--WSAYSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FQLSGCTSMKTYRAKFFGVCTDG-RCCTPHRTTTLPVEFKCPDGEV-----------MKK SMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >NP_989605.1 CCN family member 2 precursor [Gallus gallus] -----------------------------------------------MSPASLA-VALLL ALLGP------------------------------------------------------- -------EVRG---------------------------QE-CSGQC-------------- ----------------------QCGSGPGPSCPAGV--SLVLDGC--------GCCRVCA KQLGEL-CTERDPCD----------HHKG------LFCDFGSPANRRIGVC--------- TAR-----DGAPCVFSGMVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPD--- -CPYPRRVKLPGKCCEEWVCDEAKEQTAVGPALAAYRLEDT----YGPDPTM-------- -------MRANCLVQTTE--WSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTATLPVEFKCPDGEI-----------MKR KMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >NP_001267240.1 CCN family member 2 precursor [Pan troglodytes] MT------------------------------------------AASVGPVRVA-FVLLL ALCSR------------------------------------------------------- -------PAVG---------------------------QN-CSGPC-------------- ----------------------RCSDEPAPRCPAGV--SLVLDGC--------GCCRVCA KQLGEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPD--- -CPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDT----FGPDPTM-------- -------MRANCLVQTTE--WSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSMKTYRAKFCGVCTDG-RCCTPHRTTTLPVEFKCPDGEV-----------MKK NMT--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >XP_003638817.1 CCN family member 2 [Canis lupus familiaris] MS------------------------------------------AAGLGPVRGA-FLLLL ALCGR------------------------------------------------------- -------PAAG---------------------------QD-CGGQC-------------- ----------------------PCAAAPAPRCPAGV--SLVLDGC--------GCCRVCA KQLGEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCVFGGTVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPD--- -CPFPRRVKLPGKCCEEWVCDEPKDHTVVGPALAAYRLEDT----FGPDPTM-------- -------IRANCLVQTTE--WSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKIAKPVK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTTTLPVEFKCPDGEV-----------MKK NMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >XP_017200867.1 PREDICTED: connective tissue growth factor [Oryctolagus cuniculus] M-------------------------------------------AAAVGPLRFA-FVLLL ALCSR----------------------------------------ADRPF---------- ------LPAAG-----PPA-------------------QD-CGGQC-------------- ----------------------QCAAAPAPRCPAGV--SLVLDGC--------GCCRVCA KQLGEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCVFGGTVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPD--- -CPFPRRVKLPGKCCEEWVCDEPKDHTVVGPALAAYRLEDT----FGPDPTM-------- -------MRANCLVQTTE--WSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPVK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTTTLPVEFKCPDGEL-----------MKK SMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >NP_998998.2 CCN family member 2 precursor [Sus scrofa] MS------------------------------------------ATGLSPVRCA-FVLLL ALCSR------------------------------------------------------- -------PASG---------------------------QD-CSGQC-------------- ----------------------QCAAGKAPRCPAGV--SLVLDGC--------GCCRVCA KQLGEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCVFGGTVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPD--- -CPFPRRVKLPGKCCEEWVCDEPKDHTVVGPALAAYRLEDT----FGPDPTM-------- -------MRANCLVQTTE--WSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPVK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTTTLPVEFKCPDGEV-----------MKK SMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >NP_001158186.1 CCN family member 2 precursor [Ovis aries] MS------------------------------------------ATGLSPVRCA-FVLLL ALCSR------------------------------------------------------- -------PASG---------------------------QD-CSAPC-------------- ----------------------QCPAGPAPRCPAGV--SLVLDGC--------GCCRVCA KQLSEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCVFGGTVYRSGESFQSSCKYQCTCLDGSVGCVPLCSVDIRLPSPD--- -CPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDT----FGPDPTM-------- -------IRANCLVQTTE--WSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSMKTYRAKFCGVCTDG-RCCTPHRTTTLPVEFKCPDGEV-----------MKK SMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >XP_002817410.1 connective tissue growth factor [Pongo abelii] MT------------------------------------------AASVGPVRVA-FVLLL ALCSR------------------------------------------------------- -------PAVG---------------------------QN-CSGPC-------------- ----------------------RCPAEPAPRCPAGV--SLVLDGC--------GCCRVCA KQLGEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCIFGGTVYRNGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPD--- -CPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDT----FGPDPTM-------- -------IRANCLVQTTE--WSACSKTCGMGISTRVTNDNTSCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSMKTYRAKFCGVCTDG-RCCTPHRTTTLPVEFKCPDGEV-----------MKK NMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >XP_003204260.2 CCN family member 2 [Meleagris gallopavo] M-------------------------------------------KQLQDPRLLS-LILLA PL---------------------------------------------------------- -------PELGWH-------------------------KQLCSQTV-------------- ----------------------------NPIQELSQLKTLNIFSSWLFFTWFSSLTYLTL QQHKVNTSIERGLLQQ---------EKQG--GP--LGKQAAGRGSRRPGRCVTARLLPSL AAR-----DGAPCVFSGMVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPD--- -CPYPRRVKLPGKCCEEWVCDEAKEQTAVGPALAAYRLEDT----YSPDPTM-------- -------MRANCLVQTTE--WSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTATLPVEFKCPDGEI-----------MKR KMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >XP_034818756.1 CCN family member 2 [Pan paniscus] MT------------------------------------------AASVGPVRVA-FVLLL ALCSR------------------------------------------------------- -------PAVG---------------------------QN-CSGPC-------------- ----------------------RCPDEPAPRCPAGV--SLVLDGC--------GCCRVCA KQLGEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPD--- -CPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDT----FGPDPTM-------- -------MRANCLVQTTE--WSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSMKTYRAKFCGVCTDG-RCCTPHRTTTLPVEFKCPDGEV-----------MKK NMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >XP_023110145.1 CCN family member 2 [Felis catus] MS------------------------------------------AAGLGPVRCA-FVLLF ALCGR------------------------------------------------------- -------PAAG---------------------------QD-CGGPC-------------- ----------------------QCAAAPAPRCPAGV--SLVLDGC--------GCCRVCA KQLGEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCVFGGTVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPD--- -CPFPRRVKLPGKCCEEWVCDEPKDHTVVGPALAAYRLEDT----FGPDPTM-------- -------IRANCLVQTTE--WSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPVK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTTTLPVEFKCPDGEL-----------MKK SMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >XP_018885110.2 CCN family member 2 [Gorilla gorilla gorilla] MT------------------------------------------AASVGPVRVA-FVLLL ALCSR------------------------------------------------------- -------PAVG---------------------------QN-CSGPC-------------- ----------------------RCPDEPAPRCPAGV--SLVLDGC--------GCCRVCA KQLGEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPD--- -CPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDT----FGPDPTM-------- -------IRANCLVQTTE--WSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSMKTYRAKFCGVCTDG-RCCTPHRTTTLPVEFKCPDGEV-----------MKK NMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >XP_005509444.1 connective tissue growth factor [Columba livia] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPD--- -CPYPRRVKLPGKCCEEWVCDEAKEQTAVGPALAAYRLEDT----YGPDPTM-------- -------MRANCLVQTTE--WSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPVK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTATLPVEFKCPDGET-----------MKR KMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >XP_017908714.1 PREDICTED: connective tissue growth factor [Capra hircus] MS------------------------------------------ATGLSPVRCA-FVLLL ALCSR------------------------------------------------------- -------PASG---------------------------QD-CSAPC-------------- ----------------------QCPAGPVPRCPAGV--SLVLDGC--------GCCRVCA KQLSEL-CTERDPCD----------RHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCVFGGTVYRSGESFQSSCKYQCTCLDGSVGCVPLCSVDIRLPSPD--- -CPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDT----FGPDPTM-------- -------IRANCLVQTTE--WSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSMKTYRAKFCGVCTDG-RCCTPHRTTTLPVEFKCPDGEV-----------MKK SMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >XP_006030850.1 connective tissue growth factor [Alligator sinensis] ------------------------------------------------------------ ------------------------------------------------------------ ----------M---------------------------QD-L------------------ ----------------------------TPELDALM--SFLPAFV--------SYDSSIP QQPPPG-LTQPSP--------------KS------SRC-LGAQLIPSRFLL--------- AAR-----DGAPCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPD--- -CPYPRRVKLPGKCCEEWVCDEPKERTAVGPALAAYRLEDT----YGPDPTM-------- -------MRANCLVQTTE--WSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEVD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTATLPVEFKCPDGEV-----------MKR RMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >XP_006270595.1 PREDICTED: connective tissue growth factor [Alligator mississippiensis] -----------------------------------------------MGPLRLA-LPLLL ALLG-------------------------------------------------------- -------RAAA---------------------------QD-CSGQC-------------- ----------------------QCAA--PPRCPAGV--SLVPDGC--------GCCRVCA KQLGEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAR-----DGAPCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPD--- -CPYPRRVKLPGKCCEEWVCDEPKEQTAVGPALAAYRLEDT----YGPDPTM-------- -------MRANCLVQTTE--WSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEVD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTATLPVEFKCPDGEV-----------MKR RMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >XP_020738137.1 connective tissue growth factor [Odocoileus virginianus texanus] -------------------------------------------------------MML-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------DPCT----------PRF-----------FPSTP---------------- SAK-----DGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGVDVRLPSPN--- -CPFPRRVKLPGKCCEEWVCDEAKEHTVVGPALAAYRPEDT----FGPDPTM-------- -------LRANCLVQTTE--WSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTTTLPVDFKCPDGEV-----------MKK SMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >XP_040206376.1 CCN family member 2 [Rana temporaria] -----------------------------------------------MSFGKVT-AALLL TVLCW------------------------------------------------------- -------VTDA---------------------------QD-CSGEC-------------- ----------------------QCPQK-IPECSPGV--SLVQDGC--------GCCKVCA KQLGEL-CTEKDVCD----------PHKG------LFCDFGSRINRKIGVC--------- TAR-----EGAPCVFGGMVYRSGESFQSSCKYQCTCLDGGVGCVPLCSMDVRLPSPD--- -CPYPRRVKLPGKCCEEWVCDQPMEKTMVGPALPAFRMEET----YGPDPSL-------- -------MRANCLVQTTE--WSACSKTCGMGISTRVTNDNEHCRLEKQNRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPVK FEFSGCTSVKTYRAKFCGVCTDG-RCCTPHRTATLPVEFKCPDGEV-----------MKK KMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------MYYRKMY-GDMA---------- ------ >KAB0380657.1 hypothetical protein FD755_008441 [Muntiacus reevesi] MS------------------------------------------ATGLGPVCCA-FALLL ALCSR------------------------------------------------------- -------PASG---------------------------RD-CSAPC-------------- ----------------------QCPAGPEPRCPAGV--SLVLDGC--------GCCRVCA KQLSEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGMDVRLPSPN--- -CPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDT----FGPDPTM-------- -------LRANCLVQTTE--WSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTTTLPVDFKCPDGEV-----------MKK SMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >XP_043313099.1 CCN family member 2 [Cervus canadensis] MS------------------------------------------ATGLGPVCCA-FALLL ALCSR------------------------------------------------------- -------PASG---------------------------RD-CSAPC-------------- ----------------------QCPAGPEPRCPAGV--SLVLDGC--------GCCRVCA KQLSEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGVDVRLPSPS--- -CPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDT----FGPDPTM-------- -------LRANCLVQTTE--WSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTTTLPVDFKCPDGEV-----------MKK SMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >KAB0360259.1 hypothetical protein FD754_004415 [Muntiacus muntjak] MS------------------------------------------ATGLGPVCCA-LALLL ALCSR------------------------------------------------------- -------PASG---------------------------RD-CSAPC-------------- ----------------------QCPAGPEPRCPAGV--SLVLDGC--------GCCRVCA KQLSEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGMDVRLPSPN--- -CPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDT----FGPDPTM-------- -------LRANCLVQTTE--WSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTTTLPVDFKCPDGEV-----------MKK SMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >KAF4024571.1 hypothetical protein G4228_016524 [Cervus hanglu yarkandensis] MK------------------------------------------ETK---------TLKI TKTTS------------------------------------------------------- -------PASG---------------------------RD-CSAPC-------------- ----------------------QCPAGPEPRCPAGV--SLVLDGC--------GCCRVCA KQLSEL-CTERDPCD----------PHKG------LFCDFGSPANRKIGVC--------- TAK-----DGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGVDVRLPSPS--- -CPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDT----FGPDPTM-------- -------LRANCLVQTTE--WSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTTTLPVDFKCPDGEV-----------MKK SMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >NP_001081697.1 connective tissue growth factor precursor [Xenopus laevis] -----------------------------------------------MSAGKVT-AVLLF ALFCW------------------------------------------------------- -------VSDA---------------------------QE-CNGEC-------------- ----------------------QCPNK-VPVCDPGV--SLVQDGC--------GCCKVCS KQLGEL-CTERDVCD----------PHKG------LFCDFGSRVNRKIGVC--------- TAR-----EGAPCVFGGTVYRSGESFQSSCKYQCTCIDGGVGCVPLCSMDIRLPSPE--- -CPFPRRVKLPGKCCEEWVCDQPQERTLVGPALPAFRMEET----YGPDPSL-------- -------IRANCLVQTTE--WSACSKTCGMGISTRVTNDNEHCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPVK FEFSGCTSVKTYRAKFCGVCTDG-RCCTPHRTATLPVEFKCPDGEV-----------MKK NMM--------------------------------------------------------- --FIKTCACH-FNC-PG------------------------------------------- -----------DNDIFEA--------------------MYYRKMY-GDMA---------- ------ >XP_030261392.1 CCN family member 2 [Sparus aurata] ---------------------------------------------MSAGMKKMILLPFLC IMLSY------------------------------------------------------- -------MAAG---------------------------QE-CSNQC-------------- ----------------------SCPST-PPQCPPGV--SLVLDGC--------GCCRVCA KQMGEL-CTERDLCD----------PHKG------LYCDFGAPINRRIGVC--------- TAR-----DGATCVFGGMVYKSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPD--- -CPMPRRVKVPGKCCEEWECDSPYRHSFMGSALAAYREEET----YGPDPSM-------- -------MRENCLVQTTE--WSACSKTCGLGISTRVTNDNRECRLEKQTRLCMVRPCESQ LEQ--------------------------------------SIRKGKKCIRTPRLSKPMK FEISGCTTTKSYRPKFCGVCLDG-RCCTPHRTTTLPMEFKCPDGQV-----------MKK HMM--------------------------------------------------------- --FIKSCACH-HNC-PG------------------------------------------- -----------ENDIFES--------------------MYYKKMM-GDMA---------- ------ >XP_004084039.1 connective tissue growth factor [Oryzias latipes] ---------------------------------------------MFANKEKVIWLPLLC LIYSY------------------------------------------------------- -------AAAG---------------------------QE-CSGQC-------------- ----------------------SCPSA-PPRCPPGV--SLVLDGC--------GCCRVCA KQMGEL-CTDKDVCD----------PHKN------LFCDIGAPISRRIGVC--------- TAR-----EGASCVFGGTVYKSGETFQSSCKYQCTCMDGAMGCVPLCSMDIRLPSPD--- -CPMPRRVKVPGKCCEEWECDSPYKDTLLGPALSAFREEET----YGPDPNM-------- -------MRENCLVQTTE--WSACSKTCGLGISTRVTNDNHECRLEKQTRLCMVRPCESQ MEQ--------------------------------------SIKKGKKCIRTPRVSKPMK FEISGCTTTKSYRPKFCGVCLDG-RCCTPHRTTTLPMEFKCPDGQV-----------MKK HMM--------------------------------------------------------- --FIKSCACH-YNC-PG------------------------------------------- -----------ENDIFEA--------------------MYYKKMT-GDTV---------- ------ >XP_015803465.1 PREDICTED: connective tissue growth factor [Nothobranchius furzeri] ---------------------------------------------MFAGVKKMVILPVLC VMFSC------------------------------------------------------- -------MAAG---------------------------QD-CSGQC-------------- ----------------------SCPST-PPQCPPGV--SLVLDGC--------GCCRVCA KQMGEL-CTERDVCD----------PHKD------LYCDFGAPINRRIGVC--------- TAR-----EGATCVFGGMVYKSGESFQSSCKYQCTCLDGAMGCVPLCSMDIRLPSPD--- -CPMPRRVKVPGKCCEEWECDSSFT-TSMGSVLAAYREEET----YGPDPNM-------- -------RRENCLVQTTE--WSACSRTCGLGISTRVTNDNRECRLEKQTRLCMVRPCESQ LEQ--------------------------------------SIRKGKKCIRTPRVSKPMK FEISGCTTTKSYRPKFCGVCLDG-RCCTPHRTTTLPMEFKCPNGEV-----------MKK HMM--------------------------------------------------------- --FIKSCACH-YNC-PG------------------------------------------- -----------ENDIFES--------------------MYYKKMY-GDMA---------- ------ >OWK01970.1 CTGF [Cervus elaphus hippelaphus] -------------------------------------------------------MML-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------DPCI----------PRF-----------FSSSP---------------- SAK-----DGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGVDVRLPSPS--- -CPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDT----FGPDPTM-------- -------LRANCLVQTTE--WSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVRPCEAD LEE--------------------------------------NIKKGKKCIRTPKISKPIK FELSGCTSVKTYRAKFCGVCTDG-RCCTPHRTTTLPVDFKCPDGEV-----------MKK SMM--------------------------------------------------------- --FIKTCACH-YNC-PG------------------------------------------- -----------DNDIFES--------------------LYYRKMY-GDMA---------- ------ >XP_039253619.1 CCN family member 2-like [Styela clava] ---------------------------------------------MSTFYYCLLVFVILS VTSIQ------------------------------------------------------- -------TSMA---------------------------KD-CSKPC-------------- ---------------------PKCPS--VTKCAFGV--SIVPDEC--------GCCKTCA KQLYES-CDASNPCD----------HHKN------LYCSFGD-VDDTAGVC--------- VAK-----PGRSCFLNGKVYLNGESFSPSCKVHCTCIDSDFGCMPRCPVSAKIP-PN--- -CEHPRLVLKPGKCCEEWICMKSSRKSVMPKINRQIKSNESRHGKHSPRPAVFNFAAARR QPEVSLAIRGECMVQTTQ--WSACSKSCGWGVSERVTNDNKACKLMKETRLCQIRPCGED YTA--------------------------------------RVKKGKKCIRSPKATKPVR YSFSGCKT-KVYTPKYCGQCVDG-RCCTPERTKTVTVTFHCDDGFS-----------FKK RMM--------------------------------------------------------- --QIKSCSCH-RKCGSS------------------------------------------- -----------DNDIFNS----------------------YRQITKGDDKV--------- ------ >NP_730294.1 Ccn [Drosophila melanogaster] ---------------------------------------------------MLILLPLLG IF---------------------------------------------------------- ------------------------------------------------------------ ----------------------------------GN--GFV------------------- ---AEVE------------------------------------ANLSLGFK--------- AIKLPRHPNPANCSVGNTTFAHGVTFKLDCKTQCVCENGRHACSTLCPNE-QLPAPEDTI SCRSPRLVEVPGHCCKMWLCENPTAD---------------------------------- -------VYATCHNSTTSGNWTACSRSCGLGTATRHTTTHAGCHQLSNLRLCENRRCDKD DHEDNKWSRSRPLTHKRKQHRAHSHSHQRYHHHKEHEEPAHRIRKGHEC-RSIQRLGPAR IRLGECVSRKLYRPKLCGRCHRGVKCCAPAVSTTIQVELLCPLNAVDPINYVQRRQANKK RQMKEPQDDEDDDDDDDGDDNVEPEPVLQSAQLWDTVALEPIDQEFLQSHQIQIENKFIA VEWILKCECSTKNCNAGSSNISSNSNSNDNMANTNKYGYYNYKNNNRGRNHETNGEPNEP TNNNAGNNKDNEEDVVDSGNNLDHNDVDNMSSEQQPDIIPYPPSV-GESSWKAEKLRQQH HWQQNT >XP_030854983.1 kielin/chordin-like protein [Strongylocentrotus purpuratus] MALPSAVGEAERGNVRFEDSVQGCSSWPTMTWSMAESKMNLQVRSSTANSINLSWNSFLP IDGTSTQGHYVVYYTTTFSNHIQSWLGQIEAGNETHTSIRNLKDGTDYYFRVSYRIPGRG VHLEGHLSEVALHRTGTPAPLGGCEHDSRHYDEGMTIHQS-CDSVCDCLLGSWICRPRGC PPKPDVRINPVNCREEPHPDDPECCT--MIKCEEGSNDSIQPADCN-----DGGVLRVHG ETYYHE-CDEVCFCDNGVSDCTRRCPDAGQMIPDLQTCPHPTLLEPPEGEC--------- CPHWSCPPPPNSCELNGNTYEDGEYFDVDCSMRCQCLGGSVRCVPRCPVSFAVSTVN--- -CPNPTRVQLPGECCLQWECEQPAEQVCI------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------HN----------------------------------------------- ----------------------------------------------GEFP--------RH ------
BMGE Cleaned alignment of selected proteins >sp|P29279|CCN2_HUMAN CCN family member 2 OS=Homo sapiens OX=9606 GN=CCN2 PE=1 SV=2 AASMGPVRVAFVVLLALCSRCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDLFCHFGSPANRKIGVCDGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHDNDIFESLYYRKMY >sp|P29279-2|CCN2_HUMAN Isoform 2 of CCN family member 2 OS=Homo sapiens OX=9606 GN=CCN2 AASMGPVRVAFVVLLALCSRCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDLFCHFGSPANRKIGVCDGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKD---------------------------CLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHDNDIFESLYYRKMY >tr|Q5RI33|Q5RI33_DANRE Cellular communication network factor 2a OS=Danio rerio OX=7955 GN=ccn2a PE=2 SV=1 -MFSGMTQSVIALLFLTFLRCSGQCHCPEV-PPQCSPGVSLVLDTCGCCRVCAKQLGELCTERDVCDLYCDYGSPSNRRIGVCDGATCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLCGMDIRLPSPDCPMPRRVKVPGKCCEEWVCDSPRQNTFVGSALAAYREEETYGPDPSMMRENCLVQTTEWSACSKTCGLGISTRVTNDNRECRLEKQSRLCMVRPCESHLEEKIRKGKKCIRTPRVSKPMKFEISGCTTTKSYRPKFCGVCTDGRCCTPHRTATLPMEFKCPDGQVMKKQMMFIKTCACHENDIFESMYYKKMV >NP_034347.2 CCN family member 2 precursor [Mus musculus] ASVAGPISLALVLL-ALCTRCSAQCQCAAEAAPHCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDLFCDFGSPANRKIGVCDGAPCVFGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDRTAVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNTFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKIAKPVKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEIMKKNMMFIKTCACHDNDIFESLYYRKMY >NP_071602.1 CCN family member 2 precursor [Rattus norvegicus] ASVAGPVSLALVLL--LCTRCSAQCQCAAEAAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDLFCDFGSPANRKIGVCDGAPCVFGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDRTVVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNTFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKIAKPVKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEIMKKNMMFIKTCACHDNDIFESLYYRKMY >NP_776455.1 CCN family member 2 precursor [Bos taurus] ATGLGPVRCAFVLLLALCSRCSAPCQCPAGPAPRCPAGVSLVLDGCGCC-VCAKQLSELCTERDPCDLFCDFGSPTNRKIGVCDGAPYIFGGTVYQSGESFQSSCKYQCTCLDGSVGCVPLCSVDVRLPSPDCPFPRRVKLPGKCCEEWVSRDEKEHTVVGPALAAYRLEDTFGPDPTMIRANCQVQTTEWSAYSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFQLSGCTSMKTYRAKFFGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCACHDNDIFESLYYRKMY >NP_989605.1 CCN family member 2 precursor [Gallus gallus] ---MSPASLAVALLLALLGPCSGQCQCGSGPGPSCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDLFCDFGSPANRRIGVCDGAPCVFSGMVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPYPRRVKLPGKCCEEWVCDEAKEQTAVGPALAAYRLEDTYGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTATLPVEFKCPDGEIMKRKMMFIKTCACHDNDIFESLYYRKMY >NP_001267240.1 CCN family member 2 precursor [Pan troglodytes] AASVGPVRVAFVLLLALCSRCSGPCRCSDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDLFCDFGSPANRKIGVCDGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMTFIKTCACHDNDIFESLYYRKMY >XP_003638817.1 CCN family member 2 [Canis lupus familiaris] AAGLGPVRGAFLLLLALCGRCGGQCPCAAAPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDLFCDFGSPANRKIGVCDGAPCVFGGTVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDHTVVGPALAAYRLEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKIAKPVKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHDNDIFESLYYRKMY >XP_017200867.1 PREDICTED: connective tissue growth factor [Oryctolagus cuniculus] AAAVGPLRFAFVLLLALCSRCGGQCQCAAAPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDLFCDFGSPANRKIGVCDGAPCVFGGTVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDHTVVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPVKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGELMKKSMMFIKTCACHDNDIFESLYYRKMY >NP_998998.2 CCN family member 2 precursor [Sus scrofa] ATGLSPVRCAFVLLLALCSRCSGQCQCAAGKAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDLFCDFGSPANRKIGVCDGAPCVFGGTVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDHTVVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPVKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCACHDNDIFESLYYRKMY >NP_001158186.1 CCN family member 2 precursor [Ovis aries] ATGLSPVRCAFVLLLALCSRCSAPCQCPAGPAPRCPAGVSLVLDGCGCCRVCAKQLSELCTERDPCDLFCDFGSPANRKIGVCDGAPCVFGGTVYRSGESFQSSCKYQCTCLDGSVGCVPLCSVDIRLPSPDCPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCACHDNDIFESLYYRKMY >XP_002817410.1 connective tissue growth factor [Pongo abelii] AASVGPVRVAFVLLLALCSRCSGPCRCPAEPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDLFCDFGSPANRKIGVCDGAPCIFGGTVYRNGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNTSCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHDNDIFESLYYRKMY >XP_003204260.2 CCN family member 2 [Meleagris gallopavo] KQLQDPRLLSLILLAPL---CSQTV------NPIQELSQTLNIFSSSLTYLTLQQHKVNSIERGLLQLGKQAAGRGSRRPGRCDGAPCVFSGMVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPYPRRVKLPGKCCEEWVCDEAKEQTAVGPALAAYRLEDTYSPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTATLPVEFKCPDGEIMKRKMMFIKTCACHDNDIFESLYYRKMY >XP_034818756.1 CCN family member 2 [Pan paniscus] AASVGPVRVAFVLLLALCSRCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDLFCDFGSPANRKIGVCDGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHDNDIFESLYYRKMY >XP_023110145.1 CCN family member 2 [Felis catus] AAGLGPVRCAFVLLFALCGRCGGPCQCAAAPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDLFCDFGSPANRKIGVCDGAPCVFGGTVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDHTVVGPALAAYRLEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPVKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGELMKKSMMFIKTCACHDNDIFESLYYRKMY >XP_018885110.2 CCN family member 2 [Gorilla gorilla gorilla] AASVGPVRVAFVLLLALCSRCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDLFCDFGSPANRKIGVCDGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHDNDIFESLYYRKMY >XP_005509444.1 connective tissue growth factor [Columba livia] --------------------------------------------------------------------------------------------MVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPYPRRVKLPGKCCEEWVCDEAKEQTAVGPALAAYRLEDTYGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPVKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTATLPVEFKCPDGETMKRKMMFIKTCACHDNDIFESLYYRKMY >XP_017908714.1 PREDICTED: connective tissue growth factor [Capra hircus] ATGLSPVRCAFVLLLALCSRCSAPCQCPAGPVPRCPAGVSLVLDGCGCCRVCAKQLSELCTERDPCDLFCDFGSPANRKIGVCDGAPCVFGGTVYRSGESFQSSCKYQCTCLDGSVGCVPLCSVDIRLPSPDCPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCACHDNDIFESLYYRKMY >XP_006030850.1 connective tissue growth factor [Alligator sinensis] --------------------L----------TPELDALMSFLPAFVSYDSSIPQQPPPGLTQPSP--SRC-LGAQLIPSRFLLDGAPCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPYPRRVKLPGKCCEEWVCDEPKERTAVGPALAAYRLEDTYGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEVDLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTATLPVEFKCPDGEVMKRRMMFIKTCACHDNDIFESLYYRKMY >XP_006270595.1 PREDICTED: connective tissue growth factor [Alligator mississippiensis] ---MGPLRLALPLLLALLG-CSGQCQCAA--PPRCPAGVSLVPDGCGCCRVCAKQLGELCTERDPCDLFCDFGSPANRKIGVCDGAPCVFGGMVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPYPRRVKLPGKCCEEWVCDEPKEQTAVGPALAAYRLEDTYGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEVDLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTATLPVEFKCPDGEVMKRRMMFIKTCACHDNDIFESLYYRKMY >XP_020738137.1 connective tissue growth factor [Odocoileus virginianus texanus] ----------MML--------------------------------------------------DPCT----FPSTP-------DGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGVDVRLPSPNCPFPRRVKLPGKCCEEWVCDEAKEHTVVGPALAAYRPEDTFGPDPTMLRANCLVQTTEWSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVDFKCPDGEVMKKSMMFIKTCACHDNDIFESLYYRKMY >XP_040206376.1 CCN family member 2 [Rana temporaria] ---MSFGKVTAALLLTVLCWCSGECQCPQK-IPECSPGVSLVQDGCGCCKVCAKQLGELCTEKDVCDLFCDFGSRINRKIGVCEGAPCVFGGMVYRSGESFQSSCKYQCTCLDGGVGCVPLCSMDVRLPSPDCPYPRRVKLPGKCCEEWVCDQPMEKTMVGPALPAFRMEETYGPDPSLMRANCLVQTTEWSACSKTCGMGISTRVTNDNEHCRLEKQNRLCMVRPCEADLEENIKKGKKCIRTPKISKPVKFEFSGCTSVKTYRAKFCGVCTDGRCCTPHRTATLPVEFKCPDGEVMKKKMMFIKTCACHDNDIFESMYYRKMY >KAB0380657.1 hypothetical protein FD755_008441 [Muntiacus reevesi] ATGLGPVCCAFALLLALCSRCSAPCQCPAGPEPRCPAGVSLVLDGCGCCRVCAKQLSELCTERDPCDLFCDFGSPANRKIGVCDGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGMDVRLPSPNCPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDTFGPDPTMLRANCLVQTTEWSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVDFKCPDGEVMKKSMMFIKTCACHDNDIFESLYYRKMY >XP_043313099.1 CCN family member 2 [Cervus canadensis] ATGLGPVCCAFALLLALCSRCSAPCQCPAGPEPRCPAGVSLVLDGCGCCRVCAKQLSELCTERDPCDLFCDFGSPANRKIGVCDGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGVDVRLPSPSCPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDTFGPDPTMLRANCLVQTTEWSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVDFKCPDGEVMKKSMMFIKTCACHDNDIFESLYYRKMY >KAB0360259.1 hypothetical protein FD754_004415 [Muntiacus muntjak] ATGLGPVCCALALLLALCSRCSAPCQCPAGPEPRCPAGVSLVLDGCGCCRVCAKQLSELCTERDPCDLFCDFGSPANRKIGVCDGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGMDVRLPSPNCPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDTFGPDPTMLRANCLVQTTEWSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVDFKCPDGEVMKKSMMFIKTCACHDNDIFESLYYRKMY >KAF4024571.1 hypothetical protein G4228_016524 [Cervus hanglu yarkandensis] ETK--------TLKITKTTSCSAPCQCPAGPEPRCPAGVSLVLDGCGCCRVCAKQLSELCTERDPCDLFCDFGSPANRKIGVCDGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGVDVRLPSPSCPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDTFGPDPTMLRANCLVQTTEWSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVDFKCPDGEVMKKSMMFIKTCACHDNDIFESLYYRKMY >NP_001081697.1 connective tissue growth factor precursor [Xenopus laevis] ---MSAGKVTAVLLFALFCWCNGECQCPNK-VPVCDPGVSLVQDGCGCCKVCSKQLGELCTERDVCDLFCDFGSRVNRKIGVCEGAPCVFGGTVYRSGESFQSSCKYQCTCIDGGVGCVPLCSMDIRLPSPECPFPRRVKLPGKCCEEWVCDQPQERTLVGPALPAFRMEETYGPDPSLIRANCLVQTTEWSACSKTCGMGISTRVTNDNEHCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPVKFEFSGCTSVKTYRAKFCGVCTDGRCCTPHRTATLPVEFKCPDGEVMKKNMMFIKTCACHDNDIFEAMYYRKMY >XP_030261392.1 CCN family member 2 [Sparus aurata] -MSAGMKKMILPFLCIMLSYCSNQCSCPST-PPQCPPGVSLVLDGCGCCRVCAKQMGELCTERDLCDLYCDFGAPINRRIGVCDGATCVFGGMVYKSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPMPRRVKVPGKCCEEWECDSPYRHSFMGSALAAYREEETYGPDPSMMRENCLVQTTEWSACSKTCGLGISTRVTNDNRECRLEKQTRLCMVRPCESQLEQSIRKGKKCIRTPRLSKPMKFEISGCTTTKSYRPKFCGVCLDGRCCTPHRTTTLPMEFKCPDGQVMKKHMMFIKSCACHENDIFESMYYKKMM >XP_004084039.1 connective tissue growth factor [Oryzias latipes] -MFANKEKVILPLLCLIYSYCSGQCSCPSA-PPRCPPGVSLVLDGCGCCRVCAKQMGELCTDKDVCDLFCDIGAPISRRIGVCEGASCVFGGTVYKSGETFQSSCKYQCTCMDGAMGCVPLCSMDIRLPSPDCPMPRRVKVPGKCCEEWECDSPYKDTLLGPALSAFREEETYGPDPNMMRENCLVQTTEWSACSKTCGLGISTRVTNDNHECRLEKQTRLCMVRPCESQMEQSIKKGKKCIRTPRVSKPMKFEISGCTTTKSYRPKFCGVCLDGRCCTPHRTTTLPMEFKCPDGQVMKKHMMFIKSCACHENDIFEAMYYKKMT >XP_015803465.1 PREDICTED: connective tissue growth factor [Nothobranchius furzeri] -MFAGVKKMVLPVLCVMFSCCSGQCSCPST-PPQCPPGVSLVLDGCGCCRVCAKQMGELCTERDVCDLYCDFGAPINRRIGVCEGATCVFGGMVYKSGESFQSSCKYQCTCLDGAMGCVPLCSMDIRLPSPDCPMPRRVKVPGKCCEEWECDSSFT-TSMGSVLAAYREEETYGPDPNMRRENCLVQTTEWSACSRTCGLGISTRVTNDNRECRLEKQTRLCMVRPCESQLEQSIRKGKKCIRTPRVSKPMKFEISGCTTTKSYRPKFCGVCLDGRCCTPHRTTTLPMEFKCPNGEVMKKHMMFIKSCACHENDIFESMYYKKMY >OWK01970.1 CTGF [Cervus elaphus hippelaphus] ----------MML--------------------------------------------------DPCI----FSSSP-------DGAPCVFGGTVYRSGESFQSSCKYRCTCLDGAVGCVPLCGVDVRLPSPSCPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDTFGPDPTMLRANCLVQTTEWSACSKTCGMGISTRVTNDNALCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVDFKCPDGEVMKKSMMFIKTCACHDNDIFESLYYRKMY >XP_039253619.1 CCN family member 2-like [Styela clava] -MSTFYYCLLFVILSVTSIQCSKPCKCPS--VTKCAFGVSIVPDECGCCKTCAKQLYESCDASNPCDLYCSFGD-VDDTAGVCPGRSCFLNGKVYLNGESFSPSCKVHCTCIDSDFGCMPRCPVSAKIP-PNCEHPRLVLKPGKCCEEWICMKSSRKSVMPKINRQIKSNESHSPRPAVIRGECMVQTTQWSACSKSCGWGVSERVTNDNKACKLMKETRLCQIRPCGEDYTARVKKGKKCIRSPKATKPVRYSFSGCKT-KVYTPKYCGQCVDGRCCTPERTKTVTVTFHCDDGFSFKKRMMQIKSCSCHDNDIFNS--YRQIT >NP_730294.1 Ccn [Drosophila melanogaster] -------MLILPLLGIF--------------------GNGFV--------------AEV----------------ANLSLGFKNPANCSVGNTTFAHGVTFKLDCKTQCVCENGRHACSTLCPNE-QLPAPECRSPRLVEVPGHCCKMWLCENPTAD----------------------VYATCHNSTTSWTACSRSCGLGTATRHTTTHAGCHQLSNLRLCENRRCDKDDHERIRKGHEC-RSIQRLGPARIRLGECVSRKLYRPKLCGRCHRGKCCAPAVSTTIQVELLCPLNAVNKKRQMWILKCECSEEDVVDSIPYPPSV >XP_030854983.1 kielin/chordin-like protein [Strongylocentrotus purpuratus] SSTANSINLSNSFLPIDGTSCDSVCECCT--MIKCEEGSSIQPADCGVLRVHGETYYHECDEVCFCDQTCPHPTLLEPPEGECPPNSCELNGNTYEDGEYFDVDCSMRCQCLGGSVRCVPRCPVSFAVSTVNCPNPTRVQLPGECCLQWECEQPAEQVCI---------------------------------------------------------------------------------------------------------------------------------------------------------------------
PhyML tree of selected proteins (XP_039253619_1_CCN_family_member_2_like__Styela_clava_:0.88133699,XP_030854983_1_kielin_chordin_like_protein__Strongylocentrotus_purpuratus_:3.15450408,(NP_730294_1_Ccn__Drosophila_melanogaster_:6.27940669,(XP_002817410_1_connective_tissue_growth_factor__Pongo_abelii_:0.00000001,(((((KAB0360259_1_hypothetical_protein_FD754_004415__Muntiacus_muntjak_:0.00439418,KAB0380657_1_hypothetical_protein_FD755_008441__Muntiacus_reevesi_:0.00000001):0.00000001,(XP_043313099_1_CCN_family_member_2__Cervus_canadensis_:0.00000001,(KAF4024571_1_hypothetical_protein_G4228_016524__Cervus_hanglu_yarkandensis_:0.00000003,(XP_020738137_1_connective_tissue_growth_factor__Odocoileus_virginianus_texanus_:0.03031601,OWK01970_1_CTGF__Cervus_elaphus_hippelaphus_:0.00826549):0.04384036):0.05430106):0.00882283):0.04555267,(NP_776455_1_CCN_family_member_2_precursor__Bos_taurus_:0.05893049,(NP_001158186_1_CCN_family_member_2_precursor__Ovis_aries_:0.00000001,XP_017908714_1_PREDICTED__connective_tissue_growth_factor__Capra_hircus_:0.00428133):0.00902033):0.00988183):0.01746039,(NP_998998_2_CCN_family_member_2_precursor__Sus_scrofa_:0.00909153,((XP_017200867_1_PREDICTED__connective_tissue_growth_factor__Oryctolagus_cuniculus_:0.01993729,(XP_003638817_1_CCN_family_member_2__Canis_lupus_familiaris_:0.02589325,XP_023110145_1_CCN_family_member_2__Felis_catus_:0.01081298):0.00886087):0.01558664,((NP_034347_2_CCN_family_member_2_precursor__Mus_musculus_:0.01278913,NP_071602_1_CCN_family_member_2_precursor__Rattus_norvegicus_:0.00000001):0.0582271,(((XP_005509444_1_connective_tissue_growth_factor__Columba_livia_:0.01107248,(NP_989605_1_CCN_family_member_2_precursor__Gallus_gallus_:0.00000001,XP_003204260_2_CCN_family_member_2__Meleagris_gallopavo_:0.44517221):0.02594886):0.03954914,(XP_006030850_1_connective_tissue_growth_factor__Alligator_sinensis_:0.39029488,XP_006270595_1_PREDICTED__connective_tissue_growth_factor__Alligator_mississippiensis_:0.00000001):0.02925779):0.0189125,((NP_001081697_1_connective_tissue_growth_factor_precursor__Xenopus_laevis_:0.08633834,XP_040206376_1_CCN_family_member_2__Rana_temporaria_:0.04113071):0.13821893,(tr_Q5RI33_Q5RI33_DANRE_Cellular_communication_network_factor_2a_OS_Danio_rerio_OX_7955_GN_ccn2a_PE_2_SV_1:0.07331043,(XP_030261392_1_CCN_family_member_2__Sparus_aurata_:0.04292785,(XP_004084039_1_connective_tissue_growth_factor__Oryzias_latipes_:0.14255683,XP_015803465_1_PREDICTED__connective_tissue_growth_factor__Nothobranchius_furzeri_:0.06438318):0.01550493):0.12454666):0.283242):0.09750433):0.05347641):0.02094548):0.00000001):0.02188507):0.05238612,(XP_018885110_2_CCN_family_member_2__Gorilla_gorilla_gorilla_:0.00000001,((sp_P29279_2_CCN2_HUMAN_Isoform_2_of_CCN_family_member_2_OS_Homo_sapiens_OX_9606_GN_CCN2:0.00000001,sp_P29279_CCN2_HUMAN_CCN_family_member_2_OS_Homo_sapiens_OX_9606_GN_CCN2_PE_1_SV_2:0.00000001):0.01316898,(XP_034818756_1_CCN_family_member_2__Pan_paniscus_:0.00000001,NP_001267240_1_CCN_family_member_2_precursor__Pan_troglodytes_:0.00854895):0.00428862):0.00000001):0.00437125):0.00861422):0.44915305):0.84154509);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)