Click here to access PB0193 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0193 Q99972 Myocilin MYOC GLC1A, GPOA, JOAG, JOAG1, TIGR Homo_sapiens Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.

DomainsGene Ontology
PF02191 (OLF)
GO:0001968 (enables) fibronectin binding
GO:0005109 (enables) frizzled binding
GO:0005515 (enables) protein binding
GO:0030971 (enables) receptor tyrosine kinase binding
GO:0032027 (enables) myosin light chain binding
GO:0046872 (enables) metal ion binding
GO:0001649 (involved in) osteoblast differentiation
GO:0001952 (involved in) regulation of cell-matrix adhesion
GO:0001953 (involved in) negative regulation of cell-matrix adhesion
GO:0007165 (involved in) signal transduction
GO:0014068 (involved in) positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014734 (involved in) skeletal muscle hypertrophy
GO:0022011 (involved in) myelination in peripheral nervous system
GO:0030335 (involved in) positive regulation of cell migration
GO:0031175 (involved in) neuron projection development
GO:0035024 (involved in) negative regulation of Rho protein signal transduction
GO:0038031 (involved in) non-canonical Wnt signaling pathway via JNK cascade
GO:0038133 (involved in) ERBB2-ERBB3 signaling pathway
GO:0043408 (involved in) regulation of MAPK cascade
GO:0045162 (involved in) clustering of voltage-gated sodium channels
GO:0051492 (involved in) regulation of stress fiber assembly
GO:0051496 (involved in) positive regulation of stress fiber assembly
GO:0051497 (involved in) negative regulation of stress fiber assembly
GO:0051894 (involved in) positive regulation of focal adhesion assembly
GO:0051897 (involved in) positive regulation of protein kinase B signaling
GO:0051901 (involved in) positive regulation of mitochondrial depolarization
GO:0060348 (involved in) bone development
GO:1900026 (involved in) positive regulation of substrate adhesion-dependent cell spreading
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005739 (located in) mitochondrion
GO:0005741 (located in) mitochondrial outer membrane
GO:0005743 (located in) mitochondrial inner membrane
GO:0005758 (located in) mitochondrial intermembrane space
GO:0005783 (located in) endoplasmic reticulum
GO:0005791 (located in) rough endoplasmic reticulum
GO:0005794 (located in) Golgi apparatus
GO:0005929 (located in) cilium
GO:0016020 (located in) membrane
GO:0031410 (located in) cytoplasmic vesicle
GO:0033268 (located in) node of Ranvier
GO:0042995 (located in) cell projection
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)