Click here to access PB0188 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0188 P16035 Metalloproteinase inhibitor 2 TIMP2 CSC-21K, DDC8 Homo_sapiens Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

DomainsGene Ontology
PF00965 (TIMP)
GO:0002020 (enables) protease binding
GO:0004857 (enables) enzyme inhibitor activity
GO:0005515 (enables) protein binding
GO:0008191 (enables) metalloendopeptidase inhibitor activity
GO:0008270 (enables) zinc ion binding
GO:0030414 (enables) peptidase inhibitor activity
GO:0046872 (enables) metal ion binding
GO:0009725 (involved in) response to hormone
GO:0010033 (involved in) response to organic substance
GO:0010466 (involved in) negative regulation of peptidase activity
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0034097 (involved in) response to cytokine
GO:0051045 (involved in) negative regulation of membrane protein ectodomain proteolysis
GO:1905049 (involved in) negative regulation of metallopeptidase activity
GO:0005615 (is active in) extracellular space
GO:0031012 (is active in) extracellular matrix
GO:0005576 (located in) extracellular region
GO:0035580 (located in) specific granule lumen
GO:0062023 (located in) collagen-containing extracellular matrix
GO:1904724 (located in) tertiary granule lumen
GO:1904813 (located in) ficolin-1-rich granule lumen

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)