PB0187
DATABASE


Click here to access PB0187 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0187 P01042 Kininogen-1 KNG1 BDK, BK, HAE6, HK, HMWK, KNG Homo_sapiens Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

DomainsGene Ontology
PF00031 (3_Cystatin)
GO:0004866 (enables) endopeptidase inhibitor activity
GO:0004869 (enables) cysteine-type endopeptidase inhibitor activity
GO:0005102 (enables) signaling receptor binding
GO:0005515 (enables) protein binding
GO:0008201 (enables) heparin binding
GO:0008270 (enables) zinc ion binding
GO:0030414 (enables) peptidase inhibitor activity
GO:0006954 (involved in) inflammatory response
GO:0007162 (involved in) negative regulation of cell adhesion
GO:0007204 (involved in) positive regulation of cytosolic calcium ion concentration
GO:0007596 (involved in) blood coagulation
GO:0007599 (involved in) hemostasis
GO:0010466 (involved in) negative regulation of peptidase activity
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0030195 (involved in) negative regulation of blood coagulation
GO:0042311 (involved in) vasodilation
GO:0043065 (involved in) positive regulation of apoptotic process
GO:0045861 (involved in) negative regulation of proteolysis
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005886 (located in) plasma membrane
GO:0031093 (located in) platelet alpha granule lumen
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences


Created by Puigbo and Nakamura @ University of Turku (2022)