Click here to access PB0185 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0185 Q9BXN1 Asporin ASPN OS3, PLAP-1, PLAP1, SLRR1C Homo_sapiens Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.

DomainsGene Ontology
PF01462 (LRRNT)
PF13855 (2_LRR_8)
GO:0005509 (enables) calcium ion binding
GO:0005518 (enables) collagen binding
GO:0030021 (enables) extracellular matrix structural constituent conferring compression resistance
GO:0030282 (involved in) bone mineralization
GO:0030512 (involved in) negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031214 (involved in) biomineral tissue development
GO:0070171 (involved in) negative regulation of tooth mineralization
GO:1902617 (involved in) response to fluoride
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0031012 (located in) extracellular matrix
GO:0042995 (located in) cell projection
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)