Click here to access PB0184 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0184 P11047 Laminin subunit gamma-1 LAMC1 LAMB2 Homo_sapiens Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

DomainsGene Ontology
PF00052 (Laminin_B)
PF00053 (10_Laminin_EGF)
PF00055 (Laminin_N)
GO:0035633 (acts upstream of or within) maintenance of blood-brain barrier
GO:0005201 (enables) extracellular matrix structural constituent
GO:0030023 (enables) extracellular matrix constituent conferring elasticity
GO:0007155 (involved in) cell adhesion
GO:0007492 (involved in) endoderm development
GO:0009887 (involved in) animal organ morphogenesis
GO:0009888 (involved in) tissue development
GO:0016477 (involved in) cell migration
GO:0022617 (involved in) extracellular matrix disassembly
GO:0031581 (involved in) hemidesmosome assembly
GO:0034446 (involved in) substrate adhesion-dependent cell spreading
GO:0045785 (involved in) positive regulation of cell adhesion
GO:0050679 (involved in) positive regulation of epithelial cell proliferation
GO:0051149 (involved in) positive regulation of muscle cell differentiation
GO:0065003 (involved in) protein-containing complex assembly
GO:0110011 (involved in) regulation of basement membrane organization
GO:2001046 (involved in) positive regulation of integrin-mediated signaling pathway
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005615 (located in) extracellular space
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0031012 (located in) extracellular matrix
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0098637 (located in) protein complex involved in cell-matrix adhesion
GO:0005606 (part of) laminin-1 complex
GO:0043259 (part of) laminin-10 complex
GO:0043260 (part of) laminin-11 complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)