Click here to access PB0181 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0181 Q9GZV9 Fibroblast growth factor 23 FGF23 ADHR, FGFN, HFTC2, HPDR2, HYPF, PHPTC Homo_sapiens Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.

DomainsGene Ontology
PF00167 (FGF)
GO:0005104 (enables) fibroblast growth factor receptor binding
GO:0005105 (enables) type 1 fibroblast growth factor receptor binding
GO:0005515 (enables) protein binding
GO:0008083 (enables) growth factor activity
GO:0000165 (involved in) MAPK cascade
GO:0001934 (involved in) positive regulation of protein phosphorylation
GO:0006796 (involved in) phosphate-containing compound metabolic process
GO:0008284 (involved in) positive regulation of cell population proliferation
GO:0008543 (involved in) fibroblast growth factor receptor signaling pathway
GO:0009887 (involved in) animal organ morphogenesis
GO:0010628 (involved in) positive regulation of gene expression
GO:0010966 (involved in) regulation of phosphate transport
GO:0010980 (involved in) positive regulation of vitamin D 24-hydroxylase activity
GO:0030154 (involved in) cell differentiation
GO:0030334 (involved in) regulation of cell migration
GO:0030500 (involved in) regulation of bone mineralization
GO:0030502 (involved in) negative regulation of bone mineralization
GO:0030643 (involved in) cellular phosphate ion homeostasis
GO:0032026 (involved in) response to magnesium ion
GO:0042359 (involved in) vitamin D metabolic process
GO:0042369 (involved in) vitamin D catabolic process
GO:0044320 (involved in) cellular response to leptin stimulus
GO:0045668 (involved in) negative regulation of osteoblast differentiation
GO:0045893 (involved in) positive regulation of transcription, DNA-templated
GO:0046888 (involved in) negative regulation of hormone secretion
GO:0055062 (involved in) phosphate ion homeostasis
GO:0055074 (involved in) calcium ion homeostasis
GO:0070371 (involved in) ERK1 and ERK2 cascade
GO:0070374 (involved in) positive regulation of ERK1 and ERK2 cascade
GO:0071305 (involved in) cellular response to vitamin D
GO:0071354 (involved in) cellular response to interleukin-6
GO:0071374 (involved in) cellular response to parathyroid hormone stimulus
GO:0090080 (involved in) positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:1904383 (involved in) response to sodium phosphate
GO:0005615 (is active in) extracellular space
GO:0005737 (is active in) cytoplasm
GO:0005576 (located in) extracellular region
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005796 (located in) Golgi lumen

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)