Click here to access PB0179 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0179 P02649 Apolipoprotein E APOE AD2, APO-E, ApoE4, LDLCQ5, LPG Homo_sapiens This interaction is probably promoted via the up-regulation of cellular autophagy by the virus (PubMed:29695434).

DomainsGene Ontology
PF01442 (Apolipoprotein)
GO:0048662 (acts upstream of) negative regulation of smooth muscle cell proliferation
GO:0060999 (acts upstream of or within) positive regulation of dendritic spine development
GO:1902952 (acts upstream of or within) positive regulation of dendritic spine maintenance
GO:0097113 (acts upstream of or within positive effect) AMPA glutamate receptor clustering
GO:0097114 (acts upstream of or within positive effect) NMDA glutamate receptor clustering
GO:0001540 (enables) amyloid-beta binding
GO:0005102 (enables) signaling receptor binding
GO:0005198 (enables) structural molecule activity
GO:0005319 (enables) lipid transporter activity
GO:0005515 (enables) protein binding
GO:0005543 (enables) phospholipid binding
GO:0008201 (enables) heparin binding
GO:0008289 (enables) lipid binding
GO:0016209 (enables) antioxidant activity
GO:0042802 (enables) identical protein binding
GO:0042803 (enables) protein homodimerization activity
GO:0043395 (enables) heparan sulfate proteoglycan binding
GO:0044877 (enables) protein-containing complex binding
GO:0046911 (enables) metal chelating activity
GO:0046983 (enables) protein dimerization activity
GO:0048156 (enables) tau protein binding
GO:0050750 (enables) low-density lipoprotein particle receptor binding
GO:0060228 (enables) phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070326 (enables) very-low-density lipoprotein particle receptor binding
GO:0071813 (enables) lipoprotein particle binding
GO:0120020 (enables) cholesterol transfer activity
GO:0000302 (involved in) response to reactive oxygen species
GO:0001937 (involved in) negative regulation of endothelial cell proliferation
GO:0002021 (involved in) response to dietary excess
GO:0006629 (involved in) lipid metabolic process
GO:0006641 (involved in) triglyceride metabolic process
GO:0006707 (involved in) cholesterol catabolic process
GO:0006869 (involved in) lipid transport
GO:0006874 (involved in) cellular calcium ion homeostasis
GO:0006898 (involved in) receptor-mediated endocytosis
GO:0006979 (involved in) response to oxidative stress
GO:0007010 (involved in) cytoskeleton organization
GO:0007186 (involved in) G protein-coupled receptor signaling pathway
GO:0007263 (involved in) nitric oxide mediated signal transduction
GO:0007271 (involved in) synaptic transmission, cholinergic
GO:0007616 (involved in) long-term memory
GO:0008202 (involved in) steroid metabolic process
GO:0008203 (involved in) cholesterol metabolic process
GO:0010467 (involved in) gene expression
GO:0010468 (involved in) regulation of gene expression
GO:0010544 (involved in) negative regulation of platelet activation
GO:0010596 (involved in) negative regulation of endothelial cell migration
GO:0010629 (involved in) negative regulation of gene expression
GO:0010873 (involved in) positive regulation of cholesterol esterification
GO:0010875 (involved in) positive regulation of cholesterol efflux
GO:0010877 (involved in) lipid transport involved in lipid storage
GO:0010976 (involved in) positive regulation of neuron projection development
GO:0010977 (involved in) negative regulation of neuron projection development
GO:0015909 (involved in) long-chain fatty acid transport
GO:0017038 (involved in) protein import
GO:0019068 (involved in) virion assembly
GO:0019934 (involved in) cGMP-mediated signaling
GO:0030195 (involved in) negative regulation of blood coagulation
GO:0030516 (involved in) regulation of axon extension
GO:0031175 (involved in) neuron projection development
GO:0032269 (involved in) negative regulation of cellular protein metabolic process
GO:0032489 (involved in) regulation of Cdc42 protein signal transduction
GO:0032805 (involved in) positive regulation of low-density lipoprotein particle receptor catabolic process
GO:0033344 (involved in) cholesterol efflux
GO:0033700 (involved in) phospholipid efflux
GO:0034372 (involved in) very-low-density lipoprotein particle remodeling
GO:0034374 (involved in) low-density lipoprotein particle remodeling
GO:0034375 (involved in) high-density lipoprotein particle remodeling
GO:0034380 (involved in) high-density lipoprotein particle assembly
GO:0034382 (involved in) chylomicron remnant clearance
GO:0034384 (involved in) high-density lipoprotein particle clearance
GO:0034447 (involved in) very-low-density lipoprotein particle clearance
GO:0035641 (involved in) locomotory exploration behavior
GO:0042157 (involved in) lipoprotein metabolic process
GO:0042158 (involved in) lipoprotein biosynthetic process
GO:0042159 (involved in) lipoprotein catabolic process
GO:0042311 (involved in) vasodilation
GO:0042632 (involved in) cholesterol homeostasis
GO:0042981 (involved in) regulation of apoptotic process
GO:0042982 (involved in) amyloid precursor protein metabolic process
GO:0043254 (involved in) regulation of protein-containing complex assembly
GO:0043407 (involved in) negative regulation of MAP kinase activity
GO:0043524 (involved in) negative regulation of neuron apoptotic process
GO:0043537 (involved in) negative regulation of blood vessel endothelial cell migration
GO:0043691 (involved in) reverse cholesterol transport
GO:0044794 (involved in) positive regulation by host of viral process
GO:0045088 (involved in) regulation of innate immune response
GO:0045541 (involved in) negative regulation of cholesterol biosynthetic process
GO:0045807 (involved in) positive regulation of endocytosis
GO:0045893 (involved in) positive regulation of transcription, DNA-templated
GO:0046889 (involved in) positive regulation of lipid biosynthetic process
GO:0046907 (involved in) intracellular transport
GO:0048168 (involved in) regulation of neuronal synaptic plasticity
GO:0048844 (involved in) artery morphogenesis
GO:0050709 (involved in) negative regulation of protein secretion
GO:0050728 (involved in) negative regulation of inflammatory response
GO:0050807 (involved in) regulation of synapse organization
GO:0051000 (involved in) positive regulation of nitric-oxide synthase activity
GO:0051044 (involved in) positive regulation of membrane protein ectodomain proteolysis
GO:0051246 (involved in) regulation of protein metabolic process
GO:0051651 (involved in) maintenance of location in cell
GO:0055088 (involved in) lipid homeostasis
GO:0055089 (involved in) fatty acid homeostasis
GO:0061136 (involved in) regulation of proteasomal protein catabolic process
GO:0061771 (involved in) response to caloric restriction
GO:0070328 (involved in) triglyceride homeostasis
GO:0070374 (involved in) positive regulation of ERK1 and ERK2 cascade
GO:0071830 (involved in) triglyceride-rich lipoprotein particle clearance
GO:0071831 (involved in) intermediate-density lipoprotein particle clearance
GO:0072359 (involved in) circulatory system development
GO:0090090 (involved in) negative regulation of canonical Wnt signaling pathway
GO:0090181 (involved in) regulation of cholesterol metabolic process
GO:0090209 (involved in) negative regulation of triglyceride metabolic process
GO:0097006 (involved in) regulation of plasma lipoprotein particle levels
GO:0098869 (involved in) cellular oxidant detoxification
GO:0120009 (involved in) intermembrane lipid transfer
GO:1900221 (involved in) regulation of amyloid-beta clearance
GO:1900223 (involved in) positive regulation of amyloid-beta clearance
GO:1900272 (involved in) negative regulation of long-term synaptic potentiation
GO:1902430 (involved in) negative regulation of amyloid-beta formation
GO:1902991 (involved in) regulation of amyloid precursor protein catabolic process
GO:1902995 (involved in) positive regulation of phospholipid efflux
GO:1903002 (involved in) positive regulation of lipid transport across blood-brain barrier
GO:1905855 (involved in) positive regulation of heparan sulfate binding
GO:1905860 (involved in) positive regulation of heparan sulfate proteoglycan binding
GO:1905890 (involved in) regulation of cellular response to very-low-density lipoprotein particle stimulus
GO:1905906 (involved in) regulation of amyloid fibril formation
GO:1905907 (involved in) negative regulation of amyloid fibril formation
GO:1905908 (involved in) positive regulation of amyloid fibril formation
GO:2000822 (involved in) regulation of behavioral fear response
GO:0043083 (is active in) synaptic cleft
GO:0098978 (is active in) glutamatergic synapse
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005634 (located in) nucleus
GO:0005737 (located in) cytoplasm
GO:0005769 (located in) early endosome
GO:0005783 (located in) endoplasmic reticulum
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005794 (located in) Golgi apparatus
GO:0005886 (located in) plasma membrane
GO:0016020 (located in) membrane
GO:0030425 (located in) dendrite
GO:0030669 (located in) clathrin-coated endocytic vesicle membrane
GO:0031012 (located in) extracellular matrix
GO:0043025 (located in) neuronal cell body
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0071682 (located in) endocytic vesicle lumen
GO:0072562 (located in) blood microparticle
GO:1903561 (located in) extracellular vesicle
GO:0034361 (part of) very-low-density lipoprotein particle
GO:0034362 (part of) low-density lipoprotein particle
GO:0034363 (part of) intermediate-density lipoprotein particle
GO:0034364 (part of) high-density lipoprotein particle
GO:0034365 (part of) discoidal high-density lipoprotein particle
GO:0042627 (part of) chylomicron
GO:1990777 (part of) lipoprotein particle

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)