Click here to access PB0178 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0178 O14793 Growth/differentiation factor 8 MSTN GDF8, MSLHP, myostatin Homo_sapiens Acts specifically as a negative regulator of skeletal muscle growth.

DomainsGene Ontology
PF00019 (TGF_beta)
PF00688 (TGFb_propeptide)
GO:0005102 (enables) signaling receptor binding
GO:0005125 (enables) cytokine activity
GO:0005515 (enables) protein binding
GO:0008083 (enables) growth factor activity
GO:0008201 (enables) heparin binding
GO:0042802 (enables) identical protein binding
GO:0042803 (enables) protein homodimerization activity
GO:0007179 (involved in) transforming growth factor beta receptor signaling pathway
GO:0007517 (involved in) muscle organ development
GO:0009408 (involved in) response to heat
GO:0009629 (involved in) response to gravity
GO:0010592 (involved in) positive regulation of lamellipodium assembly
GO:0010759 (involved in) positive regulation of macrophage chemotaxis
GO:0010862 (involved in) positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014732 (involved in) skeletal muscle atrophy
GO:0014741 (involved in) negative regulation of muscle hypertrophy
GO:0014839 (involved in) myoblast migration involved in skeletal muscle regeneration
GO:0014850 (involved in) response to muscle activity
GO:0022602 (involved in) ovulation cycle process
GO:0033574 (involved in) response to testosterone
GO:0033673 (involved in) negative regulation of kinase activity
GO:0043403 (involved in) skeletal muscle tissue regeneration
GO:0043627 (involved in) response to estrogen
GO:0045471 (involved in) response to ethanol
GO:0045662 (involved in) negative regulation of myoblast differentiation
GO:0045893 (involved in) positive regulation of transcription, DNA-templated
GO:0046627 (involved in) negative regulation of insulin receptor signaling pathway
GO:0046716 (involved in) muscle cell cellular homeostasis
GO:0048632 (involved in) negative regulation of skeletal muscle tissue growth
GO:0051384 (involved in) response to glucocorticoid
GO:0051602 (involved in) response to electrical stimulus
GO:0051898 (involved in) negative regulation of protein kinase B signaling
GO:0060395 (involved in) SMAD protein signal transduction
GO:0071549 (involved in) cellular response to dexamethasone stimulus
GO:1902723 (involved in) negative regulation of skeletal muscle satellite cell proliferation
GO:1902725 (involved in) negative regulation of satellite cell differentiation
GO:2000818 (involved in) negative regulation of myoblast proliferation
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005737 (located in) cytoplasm

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)